Details for: SNORD45B

Gene ID: 26804

Symbol: SNORD45B

Ensembl ID: ENSG00000201487

Description: small nucleolar RNA, C/D box 45B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0531
    Cell Significance Index: 0.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0008
    Cell Significance Index: -0.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0015
    Cell Significance Index: -0.0800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0160
    Cell Significance Index: -0.1900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0182
    Cell Significance Index: -0.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0187
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0211
    Cell Significance Index: -0.2500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0228
    Cell Significance Index: -0.2600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0259
    Cell Significance Index: -0.2100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0292
    Cell Significance Index: -0.3700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0317
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0378
    Cell Significance Index: -0.5000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0394
    Cell Significance Index: -0.4900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0407
    Cell Significance Index: -0.5100
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0446
    Cell Significance Index: -0.2200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0518
    Cell Significance Index: -0.4300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0635
    Cell Significance Index: -0.4900
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.0941
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD45B is a small nucleolar RNA (snoRNA) that belongs to the C/D box family, which is characterized by the presence of a C/D box motif in its primary transcript. snoRNAs are involved in various aspects of RNA processing, including splicing, modification, and degradation. SNORD45B is specifically expressed in cells that are involved in differentiation, proliferation, and survival, such as pericytes, cardiac muscle myoblasts, and retinal pigment epithelial cells. **Pathways and Functions:** SNORD45B is implicated in several cellular pathways, including RNA processing and cellular differentiation. Its primary function is to regulate the processing of small RNAs, including microRNAs and small interfering RNAs (siRNAs). SNORD45B has been shown to interact with various RNA-binding proteins, including the C/D box-binding protein (CBP) and the RNA-binding motif protein 1 (RBM1). These interactions are essential for the regulation of RNA processing and the maintenance of cellular homeostasis. In addition to its role in RNA processing, SNORD45B has also been implicated in cellular differentiation. It has been shown to regulate the expression of genes involved in differentiation, including those involved in the development of cardiac muscle and retinal pigment epithelial cells. SNORD45B has also been shown to play a role in cell survival and apoptosis, with its expression being upregulated in response to stress and downregulated in response to apoptosis. **Clinical Significance:** SNORD45B has been identified as a significant marker in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Its expression has been found to be altered in several types of cancer, including breast, lung, and colon cancer. SNORD45B has also been implicated in cardiovascular disease, with its expression being upregulated in response to cardiac injury and downregulated in response to cardiac stress. In addition to its role in disease, SNORD45B has also been shown to have potential therapeutic applications. Its ability to regulate RNA processing and cellular differentiation makes it a potential target for the treatment of diseases involving abnormal RNA processing and cellular differentiation. Furthermore, its expression has been found to be altered in several neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, making it a potential biomarker for these diseases. In conclusion, SNORD45B is a small nucleolar RNA that plays a crucial role in RNA processing and cellular differentiation. Its expression has been identified as significantly altered in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further research is needed to fully understand the role of SNORD45B in disease and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.