Details for: IGHJ1

Gene ID: 28483

Symbol: IGHJ1

Ensembl ID: ENSG00000211905

Description: immunoglobulin heavy joining 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.0860
    Cell Significance Index: 0.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.0352
    Cell Significance Index: 0.4000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0201
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0242
    Cell Significance Index: -0.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0323
    Cell Significance Index: -0.2900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0338
    Cell Significance Index: -0.3600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0348
    Cell Significance Index: -0.2900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0364
    Cell Significance Index: -0.2900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0375
    Cell Significance Index: -0.2500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0400
    Cell Significance Index: -0.3800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0416
    Cell Significance Index: -0.4600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0417
    Cell Significance Index: -0.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0437
    Cell Significance Index: -0.4600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0444
    Cell Significance Index: -0.3800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0454
    Cell Significance Index: -0.4800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0460
    Cell Significance Index: -0.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0469
    Cell Significance Index: -0.5400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0478
    Cell Significance Index: -0.6300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0497
    Cell Significance Index: -0.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0507
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0511
    Cell Significance Index: -0.6200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0531
    Cell Significance Index: -0.5000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0538
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0554
    Cell Significance Index: -0.5600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0582
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0589
    Cell Significance Index: -0.4800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0602
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0678
    Cell Significance Index: -0.6500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0768
    Cell Significance Index: -0.4100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0970
    Cell Significance Index: -0.6200
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1070
    Cell Significance Index: -0.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Joining 1 (IGHJ1)**: IGHJ1 is a gene that encodes a protein involved in the joining of heavy chains to light chains in immunoglobulins (antibodies). 2. **Expression in Multiple Cell Types**: IGHJ1 is significantly expressed in a wide range of cells, including IgA plasmablasts, IgG plasmablasts, IgG plasma cells, goblet cells, and various types of neoplastic cells. 3. **Diverse Tissue Distribution**: IGHJ1 is found in both normal and neoplastic tissues, suggesting its involvement in various physiological and pathological processes. 4. **Pathway and Function**: IGHJ1 is involved in the adaptive immune response, specifically in the development and maturation of B cells, and plays a role in the formation of immunoglobulin complexes. **Pathways and Functions:** 1. **Adaptive Immune Response**: IGHJ1 is essential for the development and maturation of B cells, which are critical for the production of antibodies in response to pathogens. 2. **Immunoglobulin Complex Formation**: IGHJ1 is involved in the formation of immunoglobulin complexes, which are essential for the recognition and elimination of pathogens. 3. **Cell Signaling**: IGHJ1 may play a role in cell signaling pathways, influencing the behavior of B cells and other immune cells. 4. **Tissue Homeostasis**: IGHJ1 may also contribute to tissue homeostasis, maintaining the balance between different cell types and tissues. **Clinical Significance:** 1. **Immunodeficiency Disorders**: Abnormalities in IGHJ1 expression have been linked to immunodeficiency disorders, highlighting its critical role in the adaptive immune response. 2. **Cancer**: IGHJ1 is overexpressed in various types of cancer, including lymphoma and leukemia, suggesting its involvement in tumorigenesis. 3. **Autoimmune Diseases**: IGHJ1 may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by influencing the production of autoantibodies. 4. **Gastrointestinal Diseases**: IGHJ1 is expressed in goblet cells, which are involved in the production of mucins, highlighting its potential role in gastrointestinal diseases, such as inflammatory bowel disease. In conclusion, the IGHJ1 gene is a complex and multifunctional gene that plays a critical role in the adaptive immune response, tissue homeostasis, and the development of various diseases. Further research is needed to fully understand the mechanisms underlying IGHJ1 expression and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.