Details for: IGHJ1

Gene ID: 28483

Symbol: IGHJ1

Ensembl ID: ENSG00000211905

Description: immunoglobulin heavy joining 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.66
    Marker Score: 698
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.49
    Marker Score: 687
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.58
    Marker Score: 691
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.56
    Marker Score: 10,381
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,649
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.18
    Marker Score: 7,146
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.04
    Marker Score: 32,092
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.02
    Marker Score: 698
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,215
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 744
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.81
    Marker Score: 689
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.78
    Marker Score: 696
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.74
    Marker Score: 698
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.68
    Marker Score: 651
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.67
    Marker Score: 745
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 744
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 740
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.43
    Marker Score: 693
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 553
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 689

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Joining 1 (IGHJ1)**: IGHJ1 is a gene that encodes a protein involved in the joining of heavy chains to light chains in immunoglobulins (antibodies). 2. **Expression in Multiple Cell Types**: IGHJ1 is significantly expressed in a wide range of cells, including IgA plasmablasts, IgG plasmablasts, IgG plasma cells, goblet cells, and various types of neoplastic cells. 3. **Diverse Tissue Distribution**: IGHJ1 is found in both normal and neoplastic tissues, suggesting its involvement in various physiological and pathological processes. 4. **Pathway and Function**: IGHJ1 is involved in the adaptive immune response, specifically in the development and maturation of B cells, and plays a role in the formation of immunoglobulin complexes. **Pathways and Functions:** 1. **Adaptive Immune Response**: IGHJ1 is essential for the development and maturation of B cells, which are critical for the production of antibodies in response to pathogens. 2. **Immunoglobulin Complex Formation**: IGHJ1 is involved in the formation of immunoglobulin complexes, which are essential for the recognition and elimination of pathogens. 3. **Cell Signaling**: IGHJ1 may play a role in cell signaling pathways, influencing the behavior of B cells and other immune cells. 4. **Tissue Homeostasis**: IGHJ1 may also contribute to tissue homeostasis, maintaining the balance between different cell types and tissues. **Clinical Significance:** 1. **Immunodeficiency Disorders**: Abnormalities in IGHJ1 expression have been linked to immunodeficiency disorders, highlighting its critical role in the adaptive immune response. 2. **Cancer**: IGHJ1 is overexpressed in various types of cancer, including lymphoma and leukemia, suggesting its involvement in tumorigenesis. 3. **Autoimmune Diseases**: IGHJ1 may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by influencing the production of autoantibodies. 4. **Gastrointestinal Diseases**: IGHJ1 is expressed in goblet cells, which are involved in the production of mucins, highlighting its potential role in gastrointestinal diseases, such as inflammatory bowel disease. In conclusion, the IGHJ1 gene is a complex and multifunctional gene that plays a critical role in the adaptive immune response, tissue homeostasis, and the development of various diseases. Further research is needed to fully understand the mechanisms underlying IGHJ1 expression and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.