Details for: OR5K3

Gene ID: 403277

Symbol: OR5K3

Ensembl ID: ENSG00000206536

Description: olfactory receptor family 5 subfamily K member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0927
    Cell Significance Index: 1.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0895
    Cell Significance Index: 0.5300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0662
    Cell Significance Index: 0.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0387
    Cell Significance Index: -0.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0388
    Cell Significance Index: -0.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0545
    Cell Significance Index: -0.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0548
    Cell Significance Index: -0.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0585
    Cell Significance Index: -1.1700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0729
    Cell Significance Index: -0.9500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0763
    Cell Significance Index: -0.9200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0816
    Cell Significance Index: -1.0300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0860
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0892
    Cell Significance Index: -0.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0914
    Cell Significance Index: -1.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0952
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0955
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1019
    Cell Significance Index: -1.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1027
    Cell Significance Index: -0.8000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1033
    Cell Significance Index: -1.3600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1092
    Cell Significance Index: -1.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1216
    Cell Significance Index: -1.1300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1239
    Cell Significance Index: -1.4900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1378
    Cell Significance Index: -1.6500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1396
    Cell Significance Index: -1.3100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1404
    Cell Significance Index: -1.4900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1428
    Cell Significance Index: -1.6800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1435
    Cell Significance Index: -1.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1569
    Cell Significance Index: -3.0700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2119
    Cell Significance Index: -1.1300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2411
    Cell Significance Index: -2.1100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2425
    Cell Significance Index: -2.0500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2457
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR5K3 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family 5 subfamily K. Its expression is widespread, with significant presence in various cell types, including those in the central nervous system, such as glutamatergic neurons and microglial cells. The OR5K3 gene is characterized by its ability to detect chemical stimuli involved in sensory perception of smell, making it an essential component of the olfactory system. Furthermore, OR5K3 is involved in the expression and translocation of olfactory receptors, highlighting its role in regulating olfactory signaling pathways. **Pathways and Functions:** OR5K3 is involved in several olfactory-related pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR5K3 binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression and translocation of olfactory receptors**: OR5K3 regulates the expression and translocation of olfactory receptors, ensuring proper olfactory signaling. 3. **G protein-coupled receptor activity**: OR5K3 activates G proteins, which in turn regulate various cellular processes, including ion channel activity and gene expression. 4. **G protein-coupled receptor signaling pathway**: OR5K3 is involved in the G protein-coupled receptor signaling pathway, which plays a crucial role in regulating various cellular processes, including cell growth and differentiation. 5. **Odorant binding**: OR5K3 binds to odorant molecules, facilitating the detection of chemical stimuli involved in sensory perception of smell. **Clinical Significance:** OR5K3 has significant clinical implications, particularly in the context of olfactory disorders. For instance: 1. **Olfactory dysfunction**: Alterations in OR5K3 expression or function may contribute to olfactory dysfunction, which can have significant impacts on quality of life. 2. **Mucopolysaccharidosis**: Mutations in the OR5K3 gene have been associated with mucopolysaccharidosis, a group of rare genetic disorders characterized by olfactory dysfunction. 3. **Neurological disorders**: OR5K3 may play a role in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease, which often involve olfactory dysfunction. In conclusion, OR5K3 is a critical component of the human olfactory system, playing a pivotal role in the detection of chemical stimuli involved in sensory perception of smell. Further research into the functions and clinical significance of OR5K3 will undoubtedly shed light on the complex mechanisms underlying human olfaction and its potential applications in the diagnosis and treatment of olfactory disorders.

Genular Protein ID: 2312364840

Symbol: OR5K3_HUMAN

Name: Olfactory receptor 5K3

UniProtKB Accession Codes:

A6NET4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 321
  • Mass: 36711
  • Checksum: 812EDD08376360A7
  • Sequence:
    • MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY IEQRLHTPMY 
IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ FYFLCLAETT DCFLLAAMAY 
DCYVAICNPL QYHTMMSKTL CIQMTAGAYL AGNLHPMIEV EFLLRLTFCG SHQINHFFCD 
VLPLYRLSCI NPYINELVLF ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA 
SHFLSVSIFC DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK 
KIMKKRKFCH ILKQMSSPLA T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.