Details for: OR5K3

Gene ID: 403277

Symbol: OR5K3

Ensembl ID: ENSG00000206536

Description: olfactory receptor family 5 subfamily K member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.17
    Marker Score: 102506
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.86
    Marker Score: 160833
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.04
    Marker Score: 51816
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.15
    Marker Score: 7607.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 3.49
    Marker Score: 1268
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.39
    Marker Score: 6173.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.09
    Marker Score: 3107.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.82
    Marker Score: 1262
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 2.72
    Marker Score: 1205
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 2.44
    Marker Score: 1166
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.4
    Marker Score: 1266
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.16
    Marker Score: 1251
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.92
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 1.67
    Marker Score: 862
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.65
    Marker Score: 1269
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.65
    Marker Score: 983
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.62
    Marker Score: 976
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.53
    Marker Score: 10138.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.4
    Marker Score: 1255
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.29
    Marker Score: 756
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1269
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.2
    Marker Score: 1268
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.14
    Marker Score: 6903.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.13
    Marker Score: 3373
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.07
    Marker Score: 1259
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.03
    Marker Score: 825
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.02
    Marker Score: 31543.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.98
    Marker Score: 70581
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.97
    Marker Score: 46806
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4913
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 744
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1377
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.69
    Marker Score: 1263
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.61
    Marker Score: 1260
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1127
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1266
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1253
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.37
    Marker Score: 1318.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.32
    Marker Score: 4962
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.28
    Marker Score: 1683.5

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Other Information

**Key Characteristics:** OR5K3 is classified under the olfactory receptor family, which is a group of G protein-coupled receptors (GPCRs) responsible for detecting odorant molecules in the air we breathe. These receptors are expressed on the surface of olfactory sensory neurons in the nasal cavity, where they bind to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. OR5K3 is specifically involved in the detection of chemical stimuli, and its expression is not limited to olfactory sensory neurons, but also found in other cell types, such as progenitor cells, oligodendrocyte precursor cells, and microglial cells. **Pathways and Functions:** OR5K3 is a member of the G protein-coupled receptor family, which is characterized by its ability to bind to ligands, such as odorant molecules, and trigger a signaling cascade through the activation of G proteins. The OR5K3 receptor is activated by binding to specific odorant molecules, which leads to the activation of G proteins, including Gαo, Gβγ, and Gγ2. This activation triggers a downstream signaling cascade that ultimately leads to the activation of various cellular processes, including: 1. **Detection of chemical stimulus:** OR5K3 is responsible for detecting chemical stimuli involved in sensory perception of smell. 2. **Expression and translocation of olfactory receptors:** OR5K3 plays a role in the expression and translocation of olfactory receptors to the plasma membrane, where they can bind to odorant molecules. 3. **G protein-coupled receptor activity:** OR5K3 is a GPCR, which means it is involved in the regulation of various cellular processes, including cell signaling, differentiation, and proliferation. 4. **Olfactory signaling pathway:** OR5K3 is part of the olfactory signaling pathway, which involves the detection of odorant molecules, signal transduction, and the transmission of signals to the brain. **Clinical Significance:** OR5K3 has significant implications in various clinical applications, including: 1. **Olfactory disorders:** OR5K3 is involved in the detection of chemical stimuli, and its dysfunction can lead to olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders:** OR5K3 is expressed in various cell types, including microglial cells, which are involved in the regulation of immune responses. Alterations in OR5K3 expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer research:** OR5K3 is involved in the regulation of cell signaling pathways, and its dysregulation has been implicated in cancer development and progression. 4. **Pharmacological applications:** OR5K3 is a potential target for the development of novel therapeutic agents, including olfactory stimulants and anti-odorant molecules. In conclusion, OR5K3 is a critical component of the olfactory system, playing a key role in the detection of chemical stimuli involved in sensory perception of smell. Its dysregulation has significant implications in various clinical applications, including olfactory disorders, neurological disorders, cancer research, and pharmacological applications. Further research is necessary to fully understand the function and significance of OR5K3, and to explore its potential therapeutic applications.

Genular Protein ID: 2312364840

Symbol: OR5K3_HUMAN

Name: Olfactory receptor 5K3

UniProtKB Accession Codes:

A6NET4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 321
  • Mass: 36711
  • Checksum: 812EDD08376360A7
  • Sequence:
    • MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY IEQRLHTPMY 
IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ FYFLCLAETT DCFLLAAMAY 
DCYVAICNPL QYHTMMSKTL CIQMTAGAYL AGNLHPMIEV EFLLRLTFCG SHQINHFFCD 
VLPLYRLSCI NPYINELVLF ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA 
SHFLSVSIFC DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK 
KIMKKRKFCH ILKQMSSPLA T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.