Details for: TRIM64

Gene ID: 120146

Symbol: TRIM64

Ensembl ID: ENSG00000204450

Description: tripartite motif containing 64

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0733
    Cell Significance Index: 0.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0116
    Cell Significance Index: 0.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0115
    Cell Significance Index: 0.3100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.0055
    Cell Significance Index: 0.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0058
    Cell Significance Index: -0.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0078
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0081
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0082
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0104
    Cell Significance Index: -0.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0154
    Cell Significance Index: -0.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0164
    Cell Significance Index: -0.1600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0188
    Cell Significance Index: -0.1100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0259
    Cell Significance Index: -0.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0290
    Cell Significance Index: -0.3700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0417
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIM64 is a member of the tripartite motif (TRIM) family of proteins, characterized by the presence of three distinct domains: a RING finger, a B-box, and a coiled-coil region. This unique structure confers the protein with a diverse range of functions, including protein ubiquitination, regulation of gene expression, and zinc ion binding. The expression of TRIM64 is widespread, with significantly elevated levels observed in various cell types, including immune cells, smooth muscle cells, and epithelial cells. **Pathways and Functions:** TRIM64 is involved in multiple cellular pathways, including: 1. **Innate Immune Response:** TRIM64 has been shown to play a crucial role in the regulation of the innate immune response, particularly in the context of viral infections. The protein's ability to ubiquitinate and degrade viral proteins helps to limit the spread of infection. 2. **Protein Ubiquitination:** TRIM64 is a ubiquitin ligase, which means it has the capacity to tag proteins for degradation. This process is essential for maintaining protein homeostasis and regulating cellular processes. 3. **Regulation of Gene Expression:** TRIM64 can modulate gene expression by interacting with transcription factors and other regulatory proteins. This function is critical for maintaining cellular homeostasis and responding to environmental cues. 4. **Zinc Ion Binding:** The protein's ability to bind zinc ions is thought to play a role in its function as a ubiquitin ligase and in regulating gene expression. **Clinical Significance:** TRIM64 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** TRIM64 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation can contribute to immune dysregulation. 2. **Cancer:** TRIM64 has been shown to have anti-tumor effects, suggesting that its dysregulation may contribute to cancer development. 3. **Infectious Diseases:** TRIM64's role in regulating the innate immune response makes it an important target for the treatment of viral infections. In conclusion, TRIM64 is a multifaceted gene that plays a critical role in regulating various cellular processes, including the innate immune response, protein ubiquitination, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and its potential therapeutic applications.

Genular Protein ID: 1609993661

Symbol: TRI64_HUMAN

Name: Tripartite motif-containing protein 64

UniProtKB Accession Codes:

A6NGJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 DNASU 1 EMBL 2 Ensembl 1 GO 6 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 11 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 449
  • Mass: 51566
  • Checksum: 57B53A10C6E00C61
  • Sequence:
    • MDSDDLQVFQ NELICCICVN YFIDPVTIDC GHSFCRPCLC LCSEEGRAPM RCPSCRKISE 
KPNFNTNVVL KKLSSLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH 
MAHSHSPIGW AAEECREKLI KEMDYLWEIN QETRNNLNQE TRTFHSLKDY VSVRKRIITI 
QYQKMPIFLD EEEQRHLQAL EREAEELFQQ LQDSQVRMTQ HLERMKDMYR ELWETCHVPD 
VELLQDVRNV SARTDLAQMQ KPQPVNPELT SWCITGVLDM LNNFRVDSAL STEMIPCYIS 
LSEDVRYVIF GDDHLSAPTD PQGVDSFAVW GAQAFTSGKH YWEVDVTLSS NWILGVCQDS 
RTADANFVID SDERFFLISS KRSNHYSLST NSPPLIQYVQ RPLGQVGVFL DYDNGSVSFF 
DVSKGSLIYG FPPSSFSSPL RPFFCFGCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.