Details for: TRBV7 1

Gene ID: 28597

Symbol: TRBV7 1

Ensembl ID: ENSG00000211707

Description: T cell receptor beta variable 7-1 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.6
    Marker Score: 10,656
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.27
    Marker Score: 745
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.22
    Marker Score: 7,421
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,659
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.15
    Marker Score: 742
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.04
    Marker Score: 32,299
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.94
    Marker Score: 437
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,345
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 744
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.71
    Marker Score: 743
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.68
    Marker Score: 744
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.6
    Marker Score: 443
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.55
    Marker Score: 1,235
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.53
    Marker Score: 438
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.41
    Marker Score: 438
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.32
    Marker Score: 437
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.26
    Marker Score: 444
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.22
    Marker Score: 430
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.18
    Marker Score: 442
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 745
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.17
    Marker Score: 275
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1
    Marker Score: 444
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.02
    Marker Score: 896
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 439
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 443

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV7.1 is a non-functional gene, meaning it does not encode for a functional T cell receptor beta chain. This is in contrast to other TRBV genes, which are involved in the recognition of antigens and activation of the adaptive immune response. The lack of functional activity of TRBV7.1 is likely due to mutations or deletions that have rendered it non-functional. Despite this, TRBV7.1 has been found to be expressed in a variety of cell types, including those with distinct tissue-specific expression patterns. **Pathways and Functions:** TRBV7.1 has been implicated in several signaling pathways, including the adaptive immune response, cell surface receptor signaling, and plasma membrane signaling. While its non-functional nature precludes it from engaging in antigen recognition or activation of T cells, TRBV7.1 may still play a role in modulating the immune response through other mechanisms. For example, it may influence the activity of other immune cells, such as natural killer T cells, or contribute to the development and maintenance of epithelial homeostasis. In addition to its potential role in the immune response, TRBV7.1 has also been linked to the development of certain types of cancer, including colon cancer. The expression of TRBV7.1 in neoplastic cells suggests that it may play a role in tumorigenesis or tumor progression. **Clinical Significance:** The discovery of TRBV7.1 has significant implications for our understanding of the immune system and its role in disease. While its non-functional nature may limit its potential as a therapeutic target, TRBV7.1's expression in various tissues and its association with certain diseases make it an interesting candidate for further study. In the context of cancer, the expression of TRBV7.1 in neoplastic cells suggests that it may be a useful biomarker for the diagnosis or monitoring of colon cancer. Additionally, further study of TRBV7.1's role in epithelial homeostasis may provide insights into the development of strategies for maintaining gut health and preventing disease. In conclusion, TRBV7.1 is a unique and enigmatic gene that continues to puzzle immunologists. While its non-functional nature may limit its potential as a therapeutic target, its expression in various tissues and association with certain diseases make it an interesting candidate for further study. As our understanding of TRBV7.1 continues to evolve, it is likely that its significance will become increasingly clear, and its role in shaping our immune response will be better understood.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.