Details for: TRBD1

Gene ID: 28637

Symbol: TRBD1

Ensembl ID: ENSG00000282431

Description: T cell receptor beta diversity 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4273
    Cell Significance Index: 6.9200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3418
    Cell Significance Index: 8.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.2164
    Cell Significance Index: 3.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0834
    Cell Significance Index: 1.0800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0605
    Cell Significance Index: 0.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0410
    Cell Significance Index: 0.5600
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0368
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0138
    Cell Significance Index: 0.0900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0209
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0240
    Cell Significance Index: -0.3100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0278
    Cell Significance Index: -0.2800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0281
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0303
    Cell Significance Index: -0.2800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0354
    Cell Significance Index: -0.3200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0365
    Cell Significance Index: -0.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0391
    Cell Significance Index: -0.5100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0407
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1523
    Cell Significance Index: -1.7000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1636
    Cell Significance Index: -1.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1645
    Cell Significance Index: -1.5600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1789
    Cell Significance Index: -1.8500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1949
    Cell Significance Index: -2.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1957
    Cell Significance Index: -2.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2266
    Cell Significance Index: -2.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBD1 is a gene that encodes a protein involved in the regulation of T cell receptor beta diversity. The TRBD1 protein is a component of the TCR complex, which is essential for the recognition of antigens by T cells. TRBD1 is significantly expressed in various hematopoietic cells, including erythrocytes, megakaryocytes, and T cells. Notably, TRBD1 is also expressed in double-negative thymocytes, which are precursor cells to alpha-beta T cells. This expression pattern suggests that TRBD1 plays a crucial role in the development and maturation of T cells. **Pathways and Functions:** TRBD1 is involved in several key pathways that regulate the adaptive immune response. These include: 1. **Adaptive immune response:** TRBD1 is essential for the assembly and maturation of T cells, which are critical for the recognition and elimination of pathogens. 2. **T cell receptor complex:** TRBD1 is a component of the TCR complex, which is responsible for the recognition of antigens by T cells. 3. **Hematopoiesis:** TRBD1 is involved in the regulation of hematopoiesis, which is the process by which blood cells are produced in the bone marrow. 4. **Cell signaling:** TRBD1 is involved in cell signaling pathways that regulate the activation and proliferation of T cells. **Functions:** The functions of TRBD1 are multifaceted and far-reaching. These include: 1. **T cell development:** TRBD1 is essential for the development and maturation of T cells, which are critical for the adaptive immune response. 2. **Antigen recognition:** TRBD1 is involved in the recognition of antigens by T cells, which is critical for the elimination of pathogens. 3. **Immune tolerance:** TRBD1 is involved in the regulation of immune tolerance, which is the process by which the immune system distinguishes between self and non-self. 4. **Hematopoietic stem cell function:** TRBD1 is involved in the regulation of hematopoietic stem cell function, which is critical for the production of blood cells. **Clinical Significance:** TRBD1 has significant clinical implications in the context of immune-related disorders. These include: 1. **Autoimmune diseases:** TRBD1 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** TRBD1 dysregulation has been implicated in cancer, including T cell lymphoma and leukemia. 3. **Immune deficiency disorders:** TRBD1 dysregulation has been implicated in immune deficiency disorders, such as severe combined immunodeficiency (SCID). 4. **Transplantation:** TRBD1 dysregulation has been implicated in transplantation, including graft rejection and immune rejection of transplanted tissues. In conclusion, TRBD1 is a critical gene that plays a pivotal role in the regulation of adaptive immunity. Its involvement in various cellular processes, including hematopoiesis and the development of immune cells, highlights its significance in the context of immune-related disorders. Further research is needed to fully elucidate the mechanisms by which TRBD1 regulates the adaptive immune response and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.