Details for: TRBD1

Gene ID: 28637

Symbol: TRBD1

Ensembl ID: ENSG00000282431

Description: T cell receptor beta diversity 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.38
    Marker Score: 210
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 165
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 209
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBD1 is a gene that encodes a protein involved in the regulation of T cell receptor beta diversity. The TRBD1 protein is a component of the TCR complex, which is essential for the recognition of antigens by T cells. TRBD1 is significantly expressed in various hematopoietic cells, including erythrocytes, megakaryocytes, and T cells. Notably, TRBD1 is also expressed in double-negative thymocytes, which are precursor cells to alpha-beta T cells. This expression pattern suggests that TRBD1 plays a crucial role in the development and maturation of T cells. **Pathways and Functions:** TRBD1 is involved in several key pathways that regulate the adaptive immune response. These include: 1. **Adaptive immune response:** TRBD1 is essential for the assembly and maturation of T cells, which are critical for the recognition and elimination of pathogens. 2. **T cell receptor complex:** TRBD1 is a component of the TCR complex, which is responsible for the recognition of antigens by T cells. 3. **Hematopoiesis:** TRBD1 is involved in the regulation of hematopoiesis, which is the process by which blood cells are produced in the bone marrow. 4. **Cell signaling:** TRBD1 is involved in cell signaling pathways that regulate the activation and proliferation of T cells. **Functions:** The functions of TRBD1 are multifaceted and far-reaching. These include: 1. **T cell development:** TRBD1 is essential for the development and maturation of T cells, which are critical for the adaptive immune response. 2. **Antigen recognition:** TRBD1 is involved in the recognition of antigens by T cells, which is critical for the elimination of pathogens. 3. **Immune tolerance:** TRBD1 is involved in the regulation of immune tolerance, which is the process by which the immune system distinguishes between self and non-self. 4. **Hematopoietic stem cell function:** TRBD1 is involved in the regulation of hematopoietic stem cell function, which is critical for the production of blood cells. **Clinical Significance:** TRBD1 has significant clinical implications in the context of immune-related disorders. These include: 1. **Autoimmune diseases:** TRBD1 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** TRBD1 dysregulation has been implicated in cancer, including T cell lymphoma and leukemia. 3. **Immune deficiency disorders:** TRBD1 dysregulation has been implicated in immune deficiency disorders, such as severe combined immunodeficiency (SCID). 4. **Transplantation:** TRBD1 dysregulation has been implicated in transplantation, including graft rejection and immune rejection of transplanted tissues. In conclusion, TRBD1 is a critical gene that plays a pivotal role in the regulation of adaptive immunity. Its involvement in various cellular processes, including hematopoiesis and the development of immune cells, highlights its significance in the context of immune-related disorders. Further research is needed to fully elucidate the mechanisms by which TRBD1 regulates the adaptive immune response and to explore its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.