Details for: TRAJ50

Gene ID: 28705

Symbol: TRAJ50

Ensembl ID: ENSG00000211839

Description: T cell receptor alpha joining 50

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1380
    Cell Significance Index: 1.7700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0202
    Cell Significance Index: 0.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0013
    Cell Significance Index: 0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0129
    Cell Significance Index: -0.2800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0210
    Cell Significance Index: -0.4100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0244
    Cell Significance Index: -0.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0277
    Cell Significance Index: -0.3400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0282
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0308
    Cell Significance Index: -0.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0324
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0327
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0343
    Cell Significance Index: -0.4700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0357
    Cell Significance Index: -0.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0358
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0365
    Cell Significance Index: -0.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0365
    Cell Significance Index: -0.4900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0383
    Cell Significance Index: -0.4900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0388
    Cell Significance Index: -0.3400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0407
    Cell Significance Index: -0.3300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0409
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0429
    Cell Significance Index: -0.4000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0495
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0763
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TCR alpha joining chain:** TRAJ50 is a component of the TCR alpha chain, which is essential for the proper assembly and function of the TCR complex. 2. **Cell-type specificity:** TRAJ50 is expressed in a range of cell types, including CD8-positive and CD4-positive T cells, innate lymphoid cells, and retinal rod cells, underscoring its importance in different aspects of immune function. 3. **Developmental expression:** TRAJ50 is also expressed during the development of thymocytes and NK T cells, highlighting its role in the maturation of these cell types. 4. **Evolutionary conservation:** TRAJ50 has been conserved across species, suggesting its essential function in the immune system. **Pathways and Functions:** 1. **TCR signaling:** TRAJ50 plays a critical role in the assembly and function of the TCR complex, which is essential for the recognition of antigens by T cells. 2. **T cell development:** TRAJ50 is involved in the development of thymocytes and NK T cells, highlighting its importance in the maturation of these cell types. 3. **Immune regulation:** TRAJ50 may also play a role in regulating immune responses, including the activation of T cells and the production of cytokines. 4. **Gene regulation:** TRAJ50 may influence the expression of other genes involved in the immune response, including those involved in T cell proliferation and differentiation. **Clinical Significance:** 1. **Immunodeficiency disorders:** Mutations in TRAJ50 have been associated with immunodeficiency disorders, highlighting its importance in the development and function of the immune system. 2. **Autoimmune diseases:** TRAJ50 may also play a role in the development of autoimmune diseases, including those characterized by dysregulated T cell responses. 3. **Cancer immunology:** TRAJ50 may influence the immune response to cancer, with implications for the development of immunotherapies. 4. **Neurological disorders:** TRAJ50's expression in retinal rod cells and caudal ganglionic eminence-derived GABAergic cortical interneurons suggests its potential involvement in neurological disorders, including those affecting the retina and brain. In conclusion, TRAJ50 is a gene of great importance in the regulation of T cell development and function. Its expression in a range of cell types and its involvement in TCR signaling, immune regulation, and gene regulation highlight its far-reaching functions. Further research is necessary to fully elucidate the role of TRAJ50 in the immune system and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.