Details for: OR5F1

Gene ID: 338674

Symbol: OR5F1

Ensembl ID: ENSG00000149133

Description: olfactory receptor family 5 subfamily F member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.17
    Marker Score: 102506
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.86
    Marker Score: 160833
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.04
    Marker Score: 51816
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.13
    Marker Score: 7580
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 3.5
    Marker Score: 1269
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.38
    Marker Score: 6146
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.9
    Marker Score: 2923
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 2.82
    Marker Score: 1249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 2.55
    Marker Score: 1218
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.41
    Marker Score: 1267
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.39
    Marker Score: 1261
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.13
    Marker Score: 1247
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.03
    Marker Score: 1267
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.92
    Marker Score: 1265
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.84
    Marker Score: 1107
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.74
    Marker Score: 1558
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 1.67
    Marker Score: 862
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.65
    Marker Score: 983
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.65
    Marker Score: 1268
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.33
    Marker Score: 1269
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1264
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.19
    Marker Score: 1261
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7679
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.14
    Marker Score: 1266
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.08
    Marker Score: 1266
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.03
    Marker Score: 825
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.98
    Marker Score: 70581
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.97
    Marker Score: 46806
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1565
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29855
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5248
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.82
    Marker Score: 745
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.69
    Marker Score: 1259
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.6
    Marker Score: 1252
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1258
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1252
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.44
    Marker Score: 1560
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 683
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 719
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.15
    Marker Score: 881
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.14
    Marker Score: 2155

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Other Information

**Key Characteristics:** OR5F1 is a non-coding gene, meaning it does not encode a protein; instead, it regulates the expression of olfactory receptors. It is part of the olfactory receptor family, which consists of approximately 400-600 genes. These genes are responsible for encoding the olfactory receptors that detect odorant molecules in the air. OR5F1 is specifically expressed in various cell types, including glutamatergic neurons, progenitor cells, and parietal epithelial cells. Its expression is also found in the central nervous system, where it plays a role in sensory perception. **Pathways and Functions:** OR5F1 is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR5F1 regulates the expression of olfactory receptors, which are responsible for detecting odorant molecules. When an odorant binds to an olfactory receptor, it triggers a signaling cascade that ultimately leads to the perception of a specific smell. 2. **Expression and translocation of olfactory receptors:** OR5F1 regulates the expression and translocation of olfactory receptors, ensuring that the right receptors are expressed in the right location to detect specific odorants. 3. **G protein-coupled receptor activity:** OR5F1 is a G protein-coupled receptor, which means it responds to ligands (odorant molecules) by activating a signaling cascade that ultimately leads to changes in cellular behavior. 4. **G protein-coupled receptor signaling pathway:** OR5F1 is part of the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that involves multiple proteins and pathways. **Clinical Significance:** Dysregulation of OR5F1 has been implicated in various diseases, including: 1. **Olfactory disorders:** OR5F1 has been linked to olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders:** OR5F1 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Psychiatric disorders:** OR5F1 has been linked to psychiatric disorders, such as depression, anxiety, and schizophrenia. In conclusion, OR5F1 is a critical component of the human olfactory system, and its dysregulation has significant clinical implications. Further research is needed to fully understand the role of OR5F1 in human disease and to develop novel therapeutic strategies for the treatment of olfactory disorders and other diseases. **Recommendations:** 1. Further research is needed to elucidate the mechanisms of OR5F1 regulation and its role in different diseases. 2. The development of novel therapeutic strategies targeting OR5F1 and its downstream signaling pathways may provide new treatments for olfactory disorders and other diseases. 3. The study of OR5F1 expression and regulation in different cell types and tissues may provide insights into its role in human disease. **Limitations:** 1. The lack of understanding of OR5F1's role in human disease is a significant limitation of current research. 2. Further research is needed to elucidate the mechanisms of OR5F1 regulation and its role in different diseases. 3. The development of novel therapeutic strategies targeting OR5F1 and its downstream signaling pathways may require further research and validation.

Genular Protein ID: 1912865987

Symbol: OR5F1_HUMAN

Name: Olfactory receptor 5F1

UniProtKB Accession Codes:

O95221 Q495D1 Q6IFB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 6 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9787077

Title: Organization and evolution of olfactory receptor genes on human chromosome 11.

PubMed ID: 9787077

DOI: 10.1006/geno.1998.5422

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 314
  • Mass: 35132
  • Checksum: C14A9A35CD76E3A3
  • Sequence:
    • MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY 
FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY 
DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD 
SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST 
CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA 
LANVISRKRT SSFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.