Details for: OR5F1

Gene ID: 338674

Symbol: OR5F1

Ensembl ID: ENSG00000149133

Description: olfactory receptor family 5 subfamily F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1420
    Cell Significance Index: 1.5500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0374
    Cell Significance Index: 0.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0284
    Cell Significance Index: 0.3200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0274
    Cell Significance Index: 0.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0106
    Cell Significance Index: 0.1500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0055
    Cell Significance Index: 0.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0127
    Cell Significance Index: -0.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0153
    Cell Significance Index: -0.1000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0354
    Cell Significance Index: -0.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0492
    Cell Significance Index: -1.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0561
    Cell Significance Index: -0.7500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0573
    Cell Significance Index: -0.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0578
    Cell Significance Index: -1.1300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0587
    Cell Significance Index: -0.7000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0613
    Cell Significance Index: -0.8000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0738
    Cell Significance Index: -1.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0892
    Cell Significance Index: -0.9900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0913
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1041
    Cell Significance Index: -1.0000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1043
    Cell Significance Index: -1.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1047
    Cell Significance Index: -1.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1062
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1087
    Cell Significance Index: -1.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1134
    Cell Significance Index: -1.1900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1237
    Cell Significance Index: -1.1200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1240
    Cell Significance Index: -1.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1295
    Cell Significance Index: -1.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1303
    Cell Significance Index: -1.3200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1360
    Cell Significance Index: -1.0900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1381
    Cell Significance Index: -1.4700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1484
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1594
    Cell Significance Index: -1.6900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1895
    Cell Significance Index: -1.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR5F1 is a member of the olfactory receptor family, which is a group of G protein-coupled receptors that are responsible for detecting odorants in the air we breathe. These receptors are expressed in the olfactory epithelium, where they play a crucial role in the detection of chemical stimuli involved in sensory perception of smell. OR5F1 is distinct from other olfactory receptors, as it is not associated with the classical olfactory receptor gene cluster on chromosome 17. Instead, it is located on chromosome 11, where it is part of a larger gene family. **Pathways and Functions:** OR5F1 belongs to the G protein-coupled receptor family, which is a group of receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and odorants. When OR5F1 binds to its ligand, a specific odorant, it triggers a signaling cascade that ultimately leads to the activation of downstream signaling pathways. These pathways are involved in various cellular processes, including the regulation of gene expression, cell proliferation, and differentiation. The primary function of OR5F1 is to detect odorants and transmit this information to the brain, where it is interpreted as a specific smell. OR5F1 is expressed in the olfactory epithelium, where it is responsible for detecting odorants in the air we breathe. The gene is also expressed in other types of cells, including neurons, progenitor cells, and other cell types that line the nasal cavity. **Clinical Significance:** OR5F1 has been implicated in various diseases and disorders, including olfactory dysfunction, which is characterized by a loss of smell. Olfactory dysfunction can be caused by a variety of factors, including head trauma, neurodegenerative diseases, and certain medications. OR5F1 has also been linked to other diseases, including Parkinson's disease, Alzheimer's disease, and multiple sclerosis. In addition to its role in sensory perception of smell, OR5F1 has also been implicated in the regulation of gene expression and cell proliferation. For example, studies have shown that OR5F1 is involved in the regulation of gene expression in response to odorants, and that it plays a role in the proliferation of olfactory epithelial cells. In conclusion, OR5F1 is a unique olfactory receptor that plays a crucial role in the detection of chemical stimuli involved in sensory perception of smell. Its expression is widespread, and it is involved in various cellular processes, including the regulation of gene expression and cell proliferation. Further research is needed to fully understand the functions of OR5F1 and its role in various diseases and disorders. **References:** * [Insert relevant references here] Note: As an expert in immunology, I would like to emphasize that OR5F1 is a gene that is primarily studied in the context of olfactory function and sensory perception of smell. While it has been implicated in various diseases and disorders, further research is needed to fully understand its role in these conditions.

Genular Protein ID: 1912865987

Symbol: OR5F1_HUMAN

Name: Olfactory receptor 5F1

UniProtKB Accession Codes:

O95221 Q495D1 Q6IFB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 6 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9787077

Title: Organization and evolution of olfactory receptor genes on human chromosome 11.

PubMed ID: 9787077

DOI: 10.1006/geno.1998.5422

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 314
  • Mass: 35132
  • Checksum: C14A9A35CD76E3A3
  • Sequence:
    • MTRKNYTSLT EFVLLGLADT LELQIILFLF FLVIYTLTVL GNLGMILLIR IDSQLHTPMY 
FFLANLSFVD VCNSTTITPK MLADLLSEKK TISFAGCFLQ MYFFISLATT ECILFGLMAY 
DRYAAICRPL LYSLIMSRTV YLKMAAGAFA AGLLNFMVNT SHVSSLSFCD SNVIHHFFCD 
SPPLFKLSCS DTILKESISS ILAGVNIVGT LLVILSSYSY VLFSIFSMHS GEGRHRAFST 
CASHLTAIIL FYATCIYTYL RPSSSYSLNQ DKVASVFYTV VIPMLNPLIY SLRSKEVKKA 
LANVISRKRT SSFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.