Details for: LINC01551

Gene ID: 387978

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01551

Ensembl ID: ENSG00000186960

Description: long intergenic non-protein coding RNA 1551

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • radial glial cell CL0000681
    CSI 33.24
    rCSI 46.18%
    PRS 99.16
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 28.68
    rCSI 33.13%
    PRS 97.66
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 21.74
    rCSI 27.9%
    PRS 98.36
  • glioblast CL0000030
    CSI 15.62
    rCSI 24.92%
    PRS 97.64
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 9.35
    rCSI 16.51%
    PRS 97.19
  • sncg GABAergic cortical interneuron CL4023015
    CSI 8.41
    rCSI 13.53%
    PRS 96.92
  • inhibitory interneuron CL0000498
    CSI 7.95
    rCSI 18.35%
    PRS 97.21
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 7.53
    rCSI 9.37%
    PRS 96.76
  • epithelial cell CL0000066
    CSI 7.51
    rCSI 11.55%
    PRS 95.83
  • VIP GABAergic cortical interneuron CL4023016
    CSI 6.91
    rCSI 8.25%
    PRS 97.09
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 6.41
    rCSI 20.05%
    PRS 97.45
  • sst GABAergic cortical interneuron CL4023017
    CSI 6.29
    rCSI 8.11%
    PRS 97.5
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 5.66
    rCSI 20.38%
    PRS 96.57
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 5.36
    rCSI 9%
    PRS 97.45
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 5.2
    rCSI 12.63%
    PRS 96.18
  • neuroplacodal cell CL0000032
    CSI 5.13
    rCSI 47.41%
    PRS 97.05
  • L6b glutamatergic cortical neuron CL4023038
    CSI 5.02
    rCSI 15.69%
    PRS 97.1
  • astrocyte of the cerebral cortex CL0002605
    CSI 4.7
    rCSI 10.54%
    PRS 97.28
  • neural progenitor cell CL0011020
    CSI 3.99
    rCSI 17.57%
    PRS 95.36
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 3.46
    rCSI 13.09%
    PRS 96.58
  • neuron CL0000540
    CSI 3.04
    rCSI 8.11%
    PRS 95.07
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.71
    rCSI 6.48%
    PRS 96.06
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 2.69
    rCSI 15.83%
    PRS 96.64
  • direct pathway medium spiny neuron CL4023026
    CSI 2.1
    rCSI 50.28%
    PRS 95.56
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.08
    rCSI 50.12%
    PRS 95.43
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.48
    rCSI 4.87%
    PRS 95.64
  • glial cell CL0000125
    CSI 1.33
    rCSI 5.08%
    PRS 97.24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01551](/details-gene/387978) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 14. Expression data strongly indicates that [LINC01551](/details-gene/387978) is a highly specific and significant regulator within the central nervous system, particularly during development. Its expression is most prominent in neural stem and progenitor cells, including [radial glial cell](/details-cell/CL0000681)s and [neuroblast (sensu Vertebrata)](/details-cell/CL0000031)s, suggesting a fundamental role in neurogenesis. Furthermore, its significant expression in [glioblast](/details-cell/CL0000030)s points towards a potential involvement in the pathology of brain tumors like glioblastoma. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [LINC01551](/details-gene/387978) is overwhelmingly restricted to cells of the nervous system, where it appears to function as a key identity marker for progenitor and developing cell types. The most significant expression is observed in neural precursor populations. It is a top marker for [radial glial cell](/details-cell/CL0000681) (CSI: 33.24), the primary neural stem cells of the developing vertebrate brain, as well as both [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) (CSI: 28.68) and [neuroblast (sensu Vertebrata)](/details-cell/CL0000031) (CSI: 21.74). This pattern strongly suggests a crucial role in establishing and maintaining the neural progenitor pool. Beyond progenitors, [LINC01551](/details-gene/387978) retains significant expression in a variety of differentiating and mature neurons, particularly inhibitory interneurons such as [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064)s and various GABAergic subtypes. Its high significance in [glioblast](/details-cell/CL0000030)s (CSI: 15.62), a cell type associated with aggressive brain cancer, is notable and suggests its function may be co-opted or dysregulated during tumorigenesis. This is consistent with research identifying [LINC01551](/details-gene/387978) as a promoter of glioma progression [Link](https://doi.org/10.1186/s13046-019-1227-2). While also present in some [epithelial cell](/details-cell/CL0000066)s, its highest significance values are narrowly confined to the neural lineage, underscoring its specialized function in this system. ## Pathways and Molecular Function While specific pathway annotations are not provided, the cellular expression pattern of [LINC01551](/details-gene/387978) allows for functional inference. Its profound enrichment in neural stem and progenitor cells suggests it participates in core neurodevelopmental pathways that govern cell cycle control, fate specification, and differentiation. As a lncRNA, it likely functions epigenetically or post-transcriptionally to regulate the expression of key protein-coding genes involved in these processes. Its role in [glioblast](/details-cell/CL0000030)s is consistent with the dysregulation of such developmental pathways, a common hallmark of cancer. Studies suggest that in glioblastoma, it may function by sponging microRNAs, thereby de-repressing oncogenic targets and promoting tumor cell proliferation and invasion [Link](https://doi.org/10.3390/cancers13184587). ## Research Directions The highly specific expression of [LINC01551](/details-gene/387978) in both neural progenitors and glioblastoma cells presents compelling avenues for future research into both developmental biology and oncology. **Proposed Hypotheses:** 1. [LINC01551](/details-gene/387978) acts as a key regulator of neural stem cell maintenance. Its downregulation is a necessary step for the terminal differentiation of [radial glial cell](/details-cell/CL0000681)s into mature neurons and glia, and its persistent expression may lock cells in a progenitor-like state. 2. In glioblastoma, the re-expression or overexpression of [LINC01551](/details-gene/387978) contributes to the cancer stem cell phenotype, driving tumor self-renewal, therapeutic resistance, and recurrence by reactivating a latent developmental program. **Key Experimental Approach:** To test the hypothesis that [LINC01551](/details-gene/387978) drives the cancer stem cell phenotype in glioblastoma, a loss-of-function experiment could be performed. Patient-derived glioblastoma stem cell (GSC) lines, which are known to be highly tumorigenic, could be treated with antisense oligonucleotides (ASOs) specifically designed to degrade [LINC01551](/details-gene/387978) transcripts. The impact on GSC properties could be assessed by measuring changes in self-renewal capacity using limiting dilution sphere-formation assays and by evaluating the expression of stem cell markers (e.g., SOX2, Nestin) via qPCR and Western blot. A subsequent in vivo study using orthotopic xenografts in immunodeficient mice would determine if ASO-mediated knockdown of [LINC01551](/details-gene/387978) can reduce tumor initiation and prolong survival. **Therapeutic Potential:** Given its specific and high-level expression in [glioblast](/details-cell/CL0000030)s and its apparent low-to-absent expression in most other non-neural tissues, [LINC01551](/details-gene/387978) represents a promising therapeutic target. The therapeutic strategy would be **inhibition**. As a non-coding RNA, it is not targetable with small molecule inhibitors in the traditional sense, but it is an excellent candidate for nucleic acid-based therapies. The development of brain-penetrant ASOs or siRNA delivered via lipid nanoparticles to inhibit [LINC01551](/details-gene/387978) could offer a novel and highly specific treatment modality for glioblastoma, a disease with an urgent need for new therapeutic options.