NUDT15 | ENSG00000136159 | NCBI 55270

Details for: NUDT15

Gene ID: 55270

Symbol: NUDT15

Ensembl ID: ENSG00000136159

Description: nudix hydrolase 15

Associated with

Azathioprine adme
(R-HSA-9748787)
Drug adme
(R-HSA-9748784)
Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Nucleotide catabolism
(R-HSA-8956319)
Phosphate bond hydrolysis by nudt proteins
(R-HSA-2393930)
Purine catabolism
(R-HSA-74259)
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
(GO:0035539)
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
(GO:0008413)
8-oxo-dgdp phosphatase activity
(GO:0044715)
Cytosol
(GO:0005829)
Dgtp catabolic process
(GO:0006203)
Dna protection
(GO:0042262)
Metal ion binding
(GO:0046872)
Mitotic cell cycle
(GO:0000278)
Nucleobase-containing small molecule metabolic process
(GO:0055086)
Nucleoside phosphate catabolic process
(GO:1901292)
Nucleoside triphosphate diphosphatase activity
(GO:0047429)
Protein binding
(GO:0005515)
Purine nucleotide catabolic process
(GO:0006195)
Regulation of proteasomal protein catabolic process
(GO:0061136)
Response to reactive oxygen species
(GO:0000302)
Xenobiotic catabolic process
(GO:0042178)

Other Information

Proteins

NUD15_HUMAN

Genular Protein ID: 3077549325

Symbol: NUD15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NV35 A2RUR6 Q32Q27 Q6P2C9

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8810257

Title: The MutT proteins or 'Nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes.

PubMed ID: 8810257

DOI: 10.1074/jbc.271.41.25059

PubMed ID: 19419956

Title: Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.

PubMed ID: 19419956

DOI: 10.1074/jbc.m109.015289

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22556419

Title: Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.

PubMed ID: 22556419

DOI: 10.1074/jbc.m112.363010

PubMed ID: 25108385

Title: A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia.

PubMed ID: 25108385

DOI: 10.1038/ng.3060

PubMed ID: 26878724

Title: NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

PubMed ID: 26878724

DOI: 10.1038/ng.3508

PubMed ID: 26238318

Title: Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

PubMed ID: 26238318

DOI: 10.1038/ncomms8871

Sequence Information:

Length: 164
Mass: 18609
Checksum: 9FF20DA411C9E9C7
Sequence:

MTASAQPRGR RPGVGVGVVV TSCKHPRCVL LGKRKGSVGA GSFQLPGGHL EFGETWEECA 
QRETWEEAAL HLKNVHFASV VNSFIEKENY HYVTILMKGE VDVTHDSEPK NVEPEKNESW 
EWVPWEELPP LDQLFWGLRC LKEQGYDPFK EDLNHLVGYK GNHL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NUDT15

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The MutT proteins or 'Nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes. PubMed ID: 8810257

Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. PubMed ID: 19419956

Initial characterization of the human central proteome. PubMed ID: 21269460

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. PubMed ID: 22556419

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. PubMed ID: 25108385

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. PubMed ID: 26878724

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. PubMed ID: 26238318