Details for: TRBV24OR9 2

Gene ID: 6961

Symbol: TRBV24OR9 2

Ensembl ID: ENSG00000215206

Description: T cell receptor beta variable 24/OR9-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6556
    Cell Significance Index: 16.7000
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4395
    Cell Significance Index: 5.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3100
    Cell Significance Index: 5.0200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1172
    Cell Significance Index: 1.5200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0999
    Cell Significance Index: 1.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0312
    Cell Significance Index: 0.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0276
    Cell Significance Index: 0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0086
    Cell Significance Index: 0.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0071
    Cell Significance Index: -0.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0074
    Cell Significance Index: -0.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0103
    Cell Significance Index: -0.0600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0181
    Cell Significance Index: -0.3600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0199
    Cell Significance Index: -0.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0227
    Cell Significance Index: -0.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1366
    Cell Significance Index: -1.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1604
    Cell Significance Index: -1.5000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1622
    Cell Significance Index: -2.0300
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1900
    Cell Significance Index: -2.3700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2046
    Cell Significance Index: -1.9400
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.2199
    Cell Significance Index: -2.7600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2210
    Cell Significance Index: -2.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2827
    Cell Significance Index: -2.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3539
    Cell Significance Index: -1.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene:** The TRBV24OR9 2 gene is classified as a pseudogene due to its lack of functional coding potential. However, its expression in various cell types suggests that it may play a regulatory role in the immune system. 2. **T cell receptor beta variable:** The TRBV24OR9 2 gene belongs to the T cell receptor beta (TCRB) family, which is essential for the development and function of T cells, a crucial component of the adaptive immune system. 3. **Significant expression in hematopoietic cells:** The gene is expressed in hematopoietic stem cells, precursor B cells, and alpha-beta T cells, indicating its involvement in the development and differentiation of these cells. 4. **Expression in non-hematopoietic cells:** The TRBV24OR9 2 gene is also expressed in erythrocytes, mast cells, and megakaryocytes, suggesting its role in regulating immune responses and cellular differentiation in non-hematopoietic cells. **Pathways and Functions:** The TRBV24OR9 2 gene is likely involved in the regulation of immune responses and cellular differentiation through the following pathways: 1. **T cell receptor signaling:** The TRBV24OR9 2 gene may play a role in the activation and regulation of T cell receptor signaling, influencing the immune response to antigens. 2. **Cellular differentiation:** The expression of TRBV24OR9 2 in hematopoietic stem cells and precursor B cells suggests its involvement in the regulation of cellular differentiation and development. 3. **Immune regulation:** The gene's expression in erythrocytes, mast cells, and megakaryocytes may contribute to the regulation of immune responses and inflammation in these tissues. **Clinical Significance:** The TRBV24OR9 2 gene's involvement in the immune system and its expression in various cell types make it a potential target for the development of novel immunotherapies and treatments for immune-related disorders. Some potential clinical applications of this gene include: 1. **Immunotherapy:** Targeting the TRBV24OR9 2 gene could lead to the development of novel immunotherapies for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer therapy:** The gene's expression in alpha-beta T cells suggests its potential role in cancer immunotherapy, where the immune system is harnessed to target and eliminate cancer cells. 3. **Regenerative medicine:** The TRBV24OR9 2 gene's involvement in cellular differentiation and development makes it a potential target for the development of regenerative therapies for hematopoietic disorders. In conclusion, the TRBV24OR9 2 gene is a complex and multifaceted component of the immune system, with significant implications for our understanding of immune regulation and disease. Further research is necessary to fully elucidate the gene's functions and potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.