Details for: GAGE12H

Gene ID: 729442

Symbol: GAGE12H

Ensembl ID: ENSG00000224902

Description: G antigen 12H

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1247
    Cell Significance Index: 0.7800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1097
    Cell Significance Index: 0.8300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0089
    Cell Significance Index: 0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0019
    Cell Significance Index: -0.2600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0021
    Cell Significance Index: -0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0113
    Cell Significance Index: -0.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0158
    Cell Significance Index: -0.4100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0246
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0262
    Cell Significance Index: -0.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0275
    Cell Significance Index: -0.2300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0288
    Cell Significance Index: -0.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0298
    Cell Significance Index: -0.2800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0325
    Cell Significance Index: -0.4200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0329
    Cell Significance Index: -0.4800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0346
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0361
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0394
    Cell Significance Index: -0.4700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0399
    Cell Significance Index: -0.3200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0402
    Cell Significance Index: -0.3700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0405
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0409
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0446
    Cell Significance Index: -0.5900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0446
    Cell Significance Index: -0.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0460
    Cell Significance Index: -0.3000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0460
    Cell Significance Index: -0.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0463
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0485
    Cell Significance Index: -0.5800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0495
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0518
    Cell Significance Index: -0.6300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0541
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0584
    Cell Significance Index: -0.6100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0641
    Cell Significance Index: -0.3400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0641
    Cell Significance Index: -0.6300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0660
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0806
    Cell Significance Index: -0.5000
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1181
    Cell Significance Index: -0.5900
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1819
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression:** GAGE12H is significantly expressed in diverse cell types, including neurons, progenitor cells, and certain types of blood cells, indicating its role in maintaining cellular homeostasis. 2. **Cellular localization:** The gene's expression in microglial cells, a type of immune cell in the brain, hints at its involvement in neuroinflammatory processes. 3. **Lack of known functional annotation:** Despite its diverse expression patterns, the GAGE12H gene remains poorly annotated, with no established functional role attributed to it. **Pathways and Functions:** 1. **Immune regulation:** The expression of GAGE12H in microglial cells and other immune cells suggests its potential involvement in modulating immune responses, possibly influencing the development and progression of neuroinflammatory diseases. 2. **Neurotransmitter regulation:** The presence of GAGE12H in glutamatergic neurons and rod bipolar cells implies its role in neurotransmitter synthesis and release, which could impact synaptic plasticity and neuronal function. 3. **Cellular differentiation:** The gene's expression in progenitor cells and oligodendrocyte precursor cells may contribute to the regulation of cell fate decisions and differentiation processes. **Clinical Significance:** 1. **Neurodegenerative diseases:** The involvement of GAGE12H in neuroinflammatory processes and neurotransmitter regulation suggests its potential as a biomarker or therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune-mediated disorders:** The gene's expression in immune cells may contribute to the development or progression of immune-mediated disorders, such as multiple sclerosis or rheumatoid arthritis. 3. **Cancer research:** Further investigation into the role of GAGE12H in cell differentiation and immune regulation may provide insights into its potential as a cancer biomarker or therapeutic target. In conclusion, the GAGE12H gene is a complex and intriguing molecule that warrants further exploration in the realm of immunology. Elucidating its mechanisms of action and clinical significance will require a multi-faceted approach, incorporating cutting-edge technologies and collaborative research efforts. As our understanding of this gene deepens, we may uncover novel therapeutic targets and biomarkers for a range of diseases, ultimately improving human health and well-being.

Genular Protein ID: 4030770747

Symbol: GG12H_HUMAN

Name: G antigen 12H

UniProtKB Accession Codes:

A6NDE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 STRING 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18179644

Title: An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members.

PubMed ID: 18179644

DOI: 10.1111/j.1399-0039.2007.00997.x

Sequence Information:

  • Length: 117
  • Mass: 12924
  • Checksum: C35ED8C0B7D1D309
  • Sequence:
    • MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC QDPAAAQKGE 
DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.