Details for: RNU6 22P

Gene ID: 106478917

Symbol: RNU6 22P

Ensembl ID: ENSG00000207083

Description: RNA, U6 small nuclear 22, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2922
    Cell Significance Index: 2.7400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2049
    Cell Significance Index: 2.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0250
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0082
    Cell Significance Index: 0.3700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0056
    Cell Significance Index: 0.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0022
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0046
    Cell Significance Index: -0.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0082
    Cell Significance Index: -0.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0344
    Cell Significance Index: -0.3800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0561
    Cell Significance Index: -0.6500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0805
    Cell Significance Index: -1.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0895
    Cell Significance Index: -1.0700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1288
    Cell Significance Index: -1.0600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1399
    Cell Significance Index: -1.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 22P is a pseudogene, meaning that it lacks the coding potential to produce a functional protein. Despite this, it is surprisingly highly expressed in various cell types, including those involved in the immune system. Its expression is widespread, with significant levels detected in intestinal enteroendocrine cells, plasma cells, and other cell types. Notably, RNU6 22P is also expressed in abnormal and neoplastic cells, suggesting that it may play a role in cellular transformation or tumor progression. **Pathways and Functions:** The functional significance of RNU6 22P remains unclear, but several potential pathways have been proposed. One possibility is that RNU6 22P regulates immune responses by modulating the expression of other genes or influencing the activity of immune cells. For example, its expression in plasma cells and intestinal epithelial cells may be linked to the regulation of antibody production or the maintenance of intestinal homeostasis. Another hypothesis is that RNU6 22P plays a role in cellular differentiation, particularly in the development of intestinal enteroendocrine cells or goblet cells. **Clinical Significance:** The clinical significance of RNU6 22P is an area of active research, with several potential implications for human health. Given its expression in neoplastic cells, RNU6 22P may serve as a biomarker for cancer diagnosis or progression. Additionally, its involvement in immune responses suggests that it may play a role in autoimmune diseases or inflammatory conditions. Furthermore, the expression of RNU6 22P in intestinal cells raises questions about its potential role in gastrointestinal disorders, such as inflammatory bowel disease (IBD). In conclusion, the RNU6 22P gene is a complex and enigmatic pseudogene that has been found to be significantly expressed in a diverse range of cells. While its functional significance remains unclear, several potential pathways have been proposed, including regulation of immune responses and cellular differentiation. Further research is needed to fully elucidate the role of RNU6 22P in human health and disease, but its study has the potential to shed light on the intricacies of the immune system and the development of novel diagnostic and therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.