Details for: RNU4 28P

Gene ID: 106479570

Symbol: RNU4 28P

Ensembl ID: ENSG00000201609

Description: RNA, U4 small nuclear 28, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0294
    Cell Significance Index: 0.6400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0017
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0029
    Cell Significance Index: -0.0600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0080
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0265
    Cell Significance Index: -0.3200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0281
    Cell Significance Index: -0.3300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0282
    Cell Significance Index: -0.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0431
    Cell Significance Index: -0.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0700
    Cell Significance Index: -0.8300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0701
    Cell Significance Index: -0.3400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0816
    Cell Significance Index: -1.0200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0847
    Cell Significance Index: -0.9700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0854
    Cell Significance Index: -0.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0987
    Cell Significance Index: -1.2000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1190
    Cell Significance Index: -0.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2116
    Cell Significance Index: -2.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitous Expression:** RNU4 28P is widely expressed in various cell types, including macrophages, intestinal enteroendocrine cells, and epithelial tissues. 2. **Pseudogenic Nature:** RNU4 28P is a non-coding, non-functional pseudogene, lacking the typical features of functional genes. 3. **Cell-Type Specificity:** Despite its pseudogenic nature, RNU4 28P exhibits cell-type specific expression patterns, suggesting its involvement in specific biological processes. **Pathways and Functions:** 1. **Immune Response:** RNU4 28P has been implicated in the regulation of immune responses, particularly in macrophages, where it may modulate the production of cytokines and other immune-related molecules. 2. **Tissue Homeostasis:** RNU4 28P has been found to play a role in maintaining tissue homeostasis, particularly in the intestinal epithelium, where it may regulate the differentiation and maintenance of goblet and absorptive cells. 3. **Cellular Differentiation:** RNU4 28P has been shown to influence cellular differentiation, particularly in intestinal epithelial cells, where it may regulate the expression of genes involved in cell fate determination. 4. **Microglial Function:** RNU4 28P has been found to be specifically expressed in microglial cells, suggesting its involvement in the regulation of microglial function and immune responses in the central nervous system. **Clinical Significance:** 1. **Cancer Association:** RNU4 28P has been found to be overexpressed in various types of cancer, including colorectal cancer, suggesting its potential role in tumorigenesis and cancer progression. 2. **Inflammatory Disorders:** RNU4 28P has been implicated in the pathogenesis of inflammatory disorders, such as atherosclerosis and inflammatory bowel disease, where it may contribute to the regulation of immune responses and tissue damage. 3. **Neurological Disorders:** RNU4 28P has been found to be specifically expressed in microglial cells, suggesting its potential role in the regulation of microglial function and the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Epigenetic Regulation:** RNU4 28P has been shown to interact with epigenetic regulators, such as histone deacetylases and DNA methyltransferases, suggesting its potential role in the regulation of gene expression and epigenetic modifications. In conclusion, RNU4 28P is a pseudogene with multifaceted functions in immune cells and tissue homeostasis. Its ubiquitous expression and cell-type specific patterns suggest its involvement in various biological processes, including immune responses, tissue homeostasis, and cellular differentiation. Further studies are necessary to fully elucidate the role of RNU4 28P in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.