Details for: OR4C46

Gene ID: 119749

Symbol: OR4C46

Ensembl ID: ENSG00000185926

Description: olfactory receptor family 4 subfamily C member 46

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0422
    Cell Significance Index: 0.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0367
    Cell Significance Index: 0.4000
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0366
    Cell Significance Index: 0.4800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0278
    Cell Significance Index: 0.3000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0101
    Cell Significance Index: 0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0076
    Cell Significance Index: 0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0182
    Cell Significance Index: -0.4600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0293
    Cell Significance Index: -0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0409
    Cell Significance Index: -0.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0414
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0460
    Cell Significance Index: -0.7500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0486
    Cell Significance Index: -0.3500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0495
    Cell Significance Index: -0.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0508
    Cell Significance Index: -0.8700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0556
    Cell Significance Index: -0.7300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0592
    Cell Significance Index: -0.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0619
    Cell Significance Index: -0.8900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0709
    Cell Significance Index: -0.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0730
    Cell Significance Index: -0.8100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0747
    Cell Significance Index: -1.0200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0796
    Cell Significance Index: -1.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0809
    Cell Significance Index: -1.0400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0818
    Cell Significance Index: -1.0100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0821
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0827
    Cell Significance Index: -1.1000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0832
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0878
    Cell Significance Index: -0.9300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0959
    Cell Significance Index: -1.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0969
    Cell Significance Index: -0.9100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1023
    Cell Significance Index: -1.0100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1055
    Cell Significance Index: -1.2600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1093
    Cell Significance Index: -0.9200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1153
    Cell Significance Index: -0.9000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1269
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.2694
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR4C46 is a member of the olfactory receptor family, which is a group of G protein-coupled receptors (GPCRs) responsible for detecting odorant molecules in the air we breathe. These receptors are expressed on the surface of olfactory sensory neurons, responsible for transducing chemical signals into electrical signals that are transmitted to the brain. OR4C46 is specifically classified as a subfamily C member, which is distinct from other olfactory receptors. This gene is also known to be involved in the expression and translocation of olfactory receptors, indicating its role in regulating the olfactory system. **Pathways and Functions:** OR4C46 is involved in the following pathways: 1. **Detection of chemical stimulus involved in sensory perception of smell**: OR4C46 is responsible for detecting odorant molecules in the air, which is essential for our sense of smell. 2. **Expression and translocation of olfactory receptors**: OR4C46 regulates the expression and translocation of olfactory receptors, ensuring that they are properly localized on the surface of olfactory sensory neurons. 3. **G protein-coupled receptor activity**: OR4C46 is a GPCR, which means it activates a signaling cascade when bound to its ligand, resulting in a cellular response. 4. **G protein-coupled receptor signaling pathway**: OR4C46 is involved in the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular processes. 5. **Olfactory receptor activity**: OR4C46 is an olfactory receptor, which means it is specifically designed to detect odorant molecules. 6. **Olfactory signaling pathway**: OR4C46 is involved in the olfactory signaling pathway, which transduces chemical signals from the nose into electrical signals that are transmitted to the brain. **Clinical Significance:** OR4C46 has several clinical implications: 1. **Olfactory disorders**: OR4C46 may play a role in various olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders**: OR4C46 may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by olfactory dysfunction. 3. **Cancer research**: OR4C46 may have potential applications in cancer research, as olfactory receptors have been implicated in the development and progression of certain cancers. 4. **Neuroprotection**: OR4C46 may have neuroprotective effects, as it is involved in the regulation of olfactory sensory neurons, which are susceptible to neurodegenerative diseases. In conclusion, OR4C46 is a critical component of the olfactory system, involved in the detection of chemical stimuli and the regulation of olfactory receptors. Its clinical significance extends to various neurological and cancer-related disorders, making it an area of interest for further research.

Genular Protein ID: 3663171143

Symbol: O4C46_HUMAN

Name: Olfactory receptor 4C46

UniProtKB Accession Codes:

A6NHA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 309
  • Mass: 34533
  • Checksum: 0A1EF3DBE5FBFAED
  • Sequence:
    • MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS PSLGSPMYLS 
LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF GEHFFGGAEG ILLTVMAYDH 
YVAICKPLHY MTIMNQCVCA LLMGVVWMGG FLHATIQILF IFQLPFCGPN VIDHFMCDLN 
PLLNLACTDT HMLELFIAAN SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS 
HITVVILFFV PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC 
SRKDISGDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.