Details for: IGHVIII 2 1

Gene ID: 28355

Symbol: IGHVIII 2 1

Ensembl ID: ENSG00000253780

Description: immunoglobulin heavy variable (III)-2-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0080
    Cell Significance Index: -0.5100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0112
    Cell Significance Index: -0.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0117
    Cell Significance Index: -0.3000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0150
    Cell Significance Index: -0.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0171
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0194
    Cell Significance Index: -0.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0217
    Cell Significance Index: -0.2900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0228
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0244
    Cell Significance Index: -0.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0267
    Cell Significance Index: -0.2400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0280
    Cell Significance Index: -0.2600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0283
    Cell Significance Index: -0.3000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0283
    Cell Significance Index: -0.3600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0285
    Cell Significance Index: -0.3000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0290
    Cell Significance Index: -0.2700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0295
    Cell Significance Index: -0.2700
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0299
    Cell Significance Index: -0.2700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0315
    Cell Significance Index: -0.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0325
    Cell Significance Index: -0.3500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0336
    Cell Significance Index: -0.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0365
    Cell Significance Index: -0.2900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0387
    Cell Significance Index: -0.3400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0429
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0436
    Cell Significance Index: -0.4100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0451
    Cell Significance Index: -0.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0459
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0506
    Cell Significance Index: -0.3400
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0579
    Cell Significance Index: -0.5900
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0625
    Cell Significance Index: -0.4800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0632
    Cell Significance Index: -0.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0645
    Cell Significance Index: -0.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: The IGHVIII 2 1 gene is classified as a pseudogene, meaning it has lost its functional coding sequence over time. Despite this, it is transcribed and expressed in multiple cell types. 2. **Widespread expression**: This gene is expressed in a variety of immune cells, including precursor B cells, naive B cells, double negative thymocytes, and plasma cells, highlighting its significance in immune system development and function. 3. **Low sequence similarity**: The IGHVIII 2 1 gene exhibits low sequence similarity to other immunoglobulin genes, suggesting that it may have evolved from a distinct gene family. **Pathways and Functions:** The IGHVIII 2 1 gene's expression and function are intricately linked to various immunological pathways. Some key aspects include: 1. **B cell development and maturation**: The expression of IGHVIII 2 1 is crucial for B cell development and maturation, particularly during the transition from precursor B cells to mature B cells. 2. **Antibody production**: Although the IGHVIII 2 1 gene lacks a functional coding sequence, its expression may contribute to the regulation of antibody production, particularly in the context of plasma cell development. 3. **Immunoregulation**: The IGHVIII 2 1 gene may play a role in immunoregulation, influencing the balance between immune activation and tolerance. 4. **Cell signaling**: The expression of IGHVIII 2 1 may be involved in cell signaling pathways, modulating the behavior of immune cells in response to antigenic stimuli. **Clinical Significance:** The IGHVIII 2 1 gene's expression and function have significant implications for our understanding of various immune-related disorders. Some potential clinical applications and implications include: 1. **Immunodeficiency diseases**: The IGHVIII 2 1 gene's expression in precursor B cells and naive B cells may provide insights into the pathogenesis of immunodeficiency diseases, such as X-linked agammaglobulinemia. 2. **Cancer immunology**: The IGHVIII 2 1 gene's expression in plasma cells and natural killer cells may be exploited in cancer immunotherapy, targeting tumor-associated immune cells. 3. **Autoimmune diseases**: The IGHVIII 2 1 gene's role in immunoregulation and cell signaling may contribute to the understanding of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **B cell-based therapies**: The IGHVIII 2 1 gene's expression in B cells may be harnessed for the development of novel B cell-based therapies, such as antibody-based treatments. In conclusion, the IGHVIII 2 1 gene is a complex and multifaceted gene product that has far-reaching implications for our understanding of immunological processes. Further research is necessary to fully elucidate the gene's functions and to harness its potential for the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.