Details for: IGHVIII 2 1

Gene ID: 28355

Symbol: IGHVIII 2 1

Ensembl ID: ENSG00000253780

Description: immunoglobulin heavy variable (III)-2-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: The IGHVIII 2 1 gene is classified as a pseudogene, meaning it has lost its functional coding sequence over time. Despite this, it is transcribed and expressed in multiple cell types. 2. **Widespread expression**: This gene is expressed in a variety of immune cells, including precursor B cells, naive B cells, double negative thymocytes, and plasma cells, highlighting its significance in immune system development and function. 3. **Low sequence similarity**: The IGHVIII 2 1 gene exhibits low sequence similarity to other immunoglobulin genes, suggesting that it may have evolved from a distinct gene family. **Pathways and Functions:** The IGHVIII 2 1 gene's expression and function are intricately linked to various immunological pathways. Some key aspects include: 1. **B cell development and maturation**: The expression of IGHVIII 2 1 is crucial for B cell development and maturation, particularly during the transition from precursor B cells to mature B cells. 2. **Antibody production**: Although the IGHVIII 2 1 gene lacks a functional coding sequence, its expression may contribute to the regulation of antibody production, particularly in the context of plasma cell development. 3. **Immunoregulation**: The IGHVIII 2 1 gene may play a role in immunoregulation, influencing the balance between immune activation and tolerance. 4. **Cell signaling**: The expression of IGHVIII 2 1 may be involved in cell signaling pathways, modulating the behavior of immune cells in response to antigenic stimuli. **Clinical Significance:** The IGHVIII 2 1 gene's expression and function have significant implications for our understanding of various immune-related disorders. Some potential clinical applications and implications include: 1. **Immunodeficiency diseases**: The IGHVIII 2 1 gene's expression in precursor B cells and naive B cells may provide insights into the pathogenesis of immunodeficiency diseases, such as X-linked agammaglobulinemia. 2. **Cancer immunology**: The IGHVIII 2 1 gene's expression in plasma cells and natural killer cells may be exploited in cancer immunotherapy, targeting tumor-associated immune cells. 3. **Autoimmune diseases**: The IGHVIII 2 1 gene's role in immunoregulation and cell signaling may contribute to the understanding of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **B cell-based therapies**: The IGHVIII 2 1 gene's expression in B cells may be harnessed for the development of novel B cell-based therapies, such as antibody-based treatments. In conclusion, the IGHVIII 2 1 gene is a complex and multifaceted gene product that has far-reaching implications for our understanding of immunological processes. Further research is necessary to fully elucidate the gene's functions and to harness its potential for the development of novel immunotherapies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.