Details for: MBD3L5

Gene ID: 284428

Symbol: MBD3L5

Ensembl ID: ENSG00000237247

Description: methyl-CpG binding domain protein 3 like 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0008
    Cell Significance Index: 0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0002
    Cell Significance Index: 0.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0046
    Cell Significance Index: -0.0800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0076
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0079
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0081
    Cell Significance Index: -0.1200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0095
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0138
    Cell Significance Index: -0.0900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0152
    Cell Significance Index: -0.1700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0154
    Cell Significance Index: -0.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0185
    Cell Significance Index: -0.1200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0193
    Cell Significance Index: -0.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0203
    Cell Significance Index: -0.1800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0223
    Cell Significance Index: -0.2000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0311
    Cell Significance Index: -0.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MBD3L5 is a putative methyl-CpG-binding domain protein that shares structural and functional similarities with other MBD proteins. Its expression is significantly restricted to specific cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage-restricted progenitor cells, goblet cells, pericytes, neoplastic cells, and macrophages. This unique expression pattern suggests a specialized role in these cells, which may be linked to the regulation of gene expression, DNA methylation, and chromatin formation. **Pathways and Functions:** MBD3L5 is involved in several critical pathways, including: 1. **DNA methylation-dependent heterochromatin formation**: MBD3L5 is thought to play a crucial role in the regulation of gene expression through its interaction with methylated DNA regions, thereby influencing chromatin structure and heterochromatin formation. 2. **Methyl-CpG binding**: As a methyl-CpG-binding protein, MBD3L5 interacts with methylated DNA sequences, which allows it to regulate gene expression by recruiting other transcriptional repressors or activators. 3. **Negative regulation of transcription by RNA polymerase II**: MBD3L5 may inhibit the activity of RNA polymerase II, a key enzyme responsible for transcribing DNA into RNA, thereby modulating gene expression. 4. **Nucleus**: MBD3L5 is localized to the nucleus, where it can interact with other nuclear proteins and influence chromatin structure and gene expression. **Clinical Significance:** The clinical significance of MBD3L5 is still unclear, but its involvement in various cellular and immunological processes suggests potential implications in diseases characterized by dysregulated gene expression, such as cancer, autoimmune disorders, and neurological diseases. For instance: 1. **Cancer**: MBD3L5 may play a role in the regulation of tumor suppressor genes or oncogenes, influencing cancer development and progression. 2. **Autoimmune disorders**: MBD3L5 may contribute to the pathogenesis of autoimmune diseases by regulating the expression of genes involved in immune responses. 3. **Neurological diseases**: MBD3L5 may be involved in the regulation of gene expression in neurons, influencing the development or progression of neurological disorders. In conclusion, MBD3L5 is a fascinating gene that warrants further investigation into its role in immunological and cellular processes. Its unique expression pattern and involvement in critical pathways suggest potential implications in various diseases, highlighting the need for further research to unravel the mysteries of this enigmatic gene.

Genular Protein ID: 1836554788

Symbol: MB3L5_HUMAN

Name: Putative methyl-CpG-binding domain protein 3-like 5

UniProtKB Accession Codes:

A6NJ08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 208
  • Mass: 22976
  • Checksum: 3A33C517B2635EEB
  • Sequence:
    • MGEPAFTSFP SPPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP 
VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP 
GTAGESLDRA GAERVRIPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR 
RVKKARERLA KALQADRLAR QAEMLTGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.