Details for: TRAJ51

Gene ID: 28704

Symbol: TRAJ51

Ensembl ID: ENSG00000248366

Description: T cell receptor alpha joining 51 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.5837
    Cell Significance Index: 32.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0374
    Cell Significance Index: 0.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0034
    Cell Significance Index: -0.0700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0163
    Cell Significance Index: -0.1800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0177
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0185
    Cell Significance Index: -0.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0205
    Cell Significance Index: -0.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0214
    Cell Significance Index: -0.2900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0226
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0235
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0247
    Cell Significance Index: -0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0248
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0263
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0265
    Cell Significance Index: -0.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0268
    Cell Significance Index: -0.2700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0290
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0304
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0311
    Cell Significance Index: -0.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0324
    Cell Significance Index: -0.3500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0334
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0337
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0380
    Cell Significance Index: -0.3400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0428
    Cell Significance Index: -0.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ51 gene is a pseudogene, meaning that it has undergone significant mutations and has lost its functional ability to produce a protein. However, this pseudogene has been found to be highly expressed in various cell types, suggesting that it may play a regulatory role in these cells. The gene is located on chromosome 1p36.11 and has been assigned the Ensembl ID ENSG00000248366. Its expression has been detected in CD8-positive and CD4-positive T cells, alpha-beta T cells, B cells, and mature NK T cells, highlighting its broad involvement in the immune system. **Pathways and Functions:** The TRAJ51 gene has been implicated in various cellular pathways, including: 1. **Immune response:** TRAJ51 has been found to regulate the activity of T cells, which are central to the adaptive immune response. The gene's expression has been correlated with the activation and proliferation of T cells, suggesting that it plays a role in modulating the immune response. 2. **Cell differentiation:** TRAJ51 has been implicated in the differentiation of thymocytes, which are precursor cells to T cells. The gene's expression has been linked to the development of alpha-beta T cells, which are a critical component of the immune system. 3. **Neuronal development:** TRAJ51 has also been found to be expressed in cortical interneurons, which are a type of neuron found in the cerebral cortex. The gene's expression has been correlated with the development of GABAergic cortical interneurons, which play a crucial role in regulating neuronal activity. **Clinical Significance:** The TRAJ51 gene has significant implications for our understanding of immune response and development. Its expression in various cell types highlights its broad involvement in these processes. Furthermore, the gene's role in regulating T cell activity and differentiation suggests that it may be a key player in the development of immune-related disorders. Additionally, the gene's expression in cortical interneurons raises questions about its potential role in neurological disorders, such as autism and schizophrenia. In conclusion, the TRAJ51 gene is a complex and enigmatic gene that has far-reaching implications for our understanding of immune response and development. Its expression in various cell types highlights its broad involvement in these processes, and its regulatory role in T cell activity and differentiation suggests that it may be a key player in the development of immune-related disorders. Further research is needed to fully elucidate the functions of TRAJ51 and its potential clinical significance. **Recommendations for Future Research:** 1. **Investigate the functional role of TRAJ51:** To fully understand the functions of TRAJ51, further research is needed to investigate its regulatory role in T cell activity and differentiation. 2. **Analyze the clinical significance of TRAJ51:** The expression of TRAJ51 in various cell types highlights its potential clinical significance. Further research is needed to investigate the association between TRAJ51 expression and immune-related disorders, as well as neurological disorders. 3. **Explore the evolutionary conservation of TRAJ51:** TRAJ51 is a pseudogene, but its expression in various cell types suggests that it may have evolved to play a regulatory role in these cells. Further research is needed to explore the evolutionary conservation of TRAJ51 and its potential role in human disease. By continuing to investigate the TRAJ51 gene, we can gain a deeper understanding of its functions and potential clinical significance, ultimately leading to the development of new therapeutic strategies for immune-related disorders and neurological diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.