Details for: TRAJ36

Gene ID: 28719

Symbol: TRAJ36

Ensembl ID: ENSG00000276699

Description: T cell receptor alpha joining 36

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0364
    Cell Significance Index: 0.4100
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: 0.0041
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0042
    Cell Significance Index: -0.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0077
    Cell Significance Index: -0.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0083
    Cell Significance Index: -0.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0088
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0099
    Cell Significance Index: -0.0900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0157
    Cell Significance Index: -0.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0179
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0181
    Cell Significance Index: -0.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0193
    Cell Significance Index: -0.2600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0209
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0244
    Cell Significance Index: -0.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0266
    Cell Significance Index: -0.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0280
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0289
    Cell Significance Index: -0.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0303
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0323
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0348
    Cell Significance Index: -0.3000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0367
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0383
    Cell Significance Index: -0.3600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0394
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0396
    Cell Significance Index: -0.3200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0408
    Cell Significance Index: -0.3600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0412
    Cell Significance Index: -0.3200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0422
    Cell Significance Index: -0.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0429
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0449
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ36 is a non-coding gene that is part of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. The gene's unique structure, comprising multiple exons and introns, enables it to interact with various TCR components, influencing the assembly and function of the TCR complex. Notably, TRAJ36 is highly expressed in CD8-positive, alpha-beta T cells, as well as in CD4-positive, alpha-beta T cells, highlighting its importance in the development and maturation of these T cell subsets. **Pathways and Functions:** TRAJ36 is intricately involved in the signaling pathways that govern T cell activation, proliferation, and differentiation. The gene's interactions with other TCR components, such as TCR alpha and beta chains, influence the assembly and function of the TCR complex, which is critical for antigen recognition and signaling. Additionally, TRAJ36 is linked to the Notch signaling pathway, a key regulator of T cell development and differentiation. The gene's expression in B cells and neural cells suggests its broader role in immune homeostasis and neuronal development. **Clinical Significance:** Dysregulation of TRAJ36 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For instance, alterations in TRAJ36 expression have been observed in patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system. Similarly, TRAJ36 has been linked to the development of certain types of cancer, such as lymphoma and leukemia, where immune dysregulation plays a critical role. Further research into the functions and dysregulations of TRAJ36 is essential for developing novel therapeutic strategies to target these immune-related disorders. **Conclusion:** In conclusion, the TRAJ36 gene is a complex and multifaceted component of the immune system, playing a critical role in the development, function, and regulation of various immune cells. Further research into the functions and dysregulations of TRAJ36 is essential for understanding the underlying mechanisms of immune-related disorders and developing novel therapeutic strategies to target these conditions. As an expert immunologist, I believe that a deeper understanding of TRAJ36 will provide valuable insights into the intricate mechanisms of immune homeostasis and the development of novel therapeutic approaches to modulate immune responses.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.