Details for: OR6S1

Gene ID: 341799

Symbol: OR6S1

Ensembl ID: ENSG00000181803

Description: olfactory receptor family 6 subfamily S member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0445
    Cell Significance Index: 0.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0184
    Cell Significance Index: 0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0098
    Cell Significance Index: 0.1100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0071
    Cell Significance Index: 0.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0180
    Cell Significance Index: -0.2300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0204
    Cell Significance Index: -0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0236
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0354
    Cell Significance Index: -0.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0421
    Cell Significance Index: -1.0700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0501
    Cell Significance Index: -0.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0533
    Cell Significance Index: -1.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0603
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0699
    Cell Significance Index: -1.1300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0724
    Cell Significance Index: -0.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0748
    Cell Significance Index: -1.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0907
    Cell Significance Index: -1.0700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0909
    Cell Significance Index: -1.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0914
    Cell Significance Index: -1.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0923
    Cell Significance Index: -1.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0969
    Cell Significance Index: -0.9800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1016
    Cell Significance Index: -1.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1025
    Cell Significance Index: -1.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1044
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1046
    Cell Significance Index: -1.2900
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1102
    Cell Significance Index: -1.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1108
    Cell Significance Index: -1.3300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1333
    Cell Significance Index: -1.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1407
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1610
    Cell Significance Index: -1.7000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1886
    Cell Significance Index: -1.0100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2007
    Cell Significance Index: -1.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR6S1 is a member of the olfactory receptor family, which is responsible for detecting odorants and transmitting this information to the brain, enabling us to perceive smells. 2. **Cellular Distribution:** OR6S1 is expressed in a wide range of cell types, including pericytes, renal cells, cardiac endothelial cells, intestinal crypt stem cells, goblet cells, and immature innate lymphoid cells, suggesting its involvement in various physiological processes. 3. **G Protein-Coupled Receptor Activity:** OR6S1's ability to activate G protein-coupled receptors (GPCRs) underscores its role in signaling pathways, which are crucial for regulating cellular responses to odorants. 4. **Expression and Translocation:** OR6S1's expression and translocation in specific cell types suggest its involvement in regulating cellular processes, such as proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR6S1's role in detecting odorants and transmitting this information to the brain enables us to perceive smells and differentiate between various odors. 2. **G Protein-Coupled Receptor Signaling Pathway:** OR6S1's activation of GPCRs triggers a signaling cascade that regulates various cellular responses, including changes in gene expression, cell proliferation, and survival. 3. **Olfactory Signaling Pathway:** OR6S1's involvement in the olfactory signaling pathway highlights its critical role in regulating sensory perception and odor detection. 4. **Regulation of Physiological Processes:** OR6S1's presence in multiple cell types suggests its involvement in regulating various physiological processes, including cardiovascular function, renal function, and intestinal function. **Clinical Significance:** 1. **Olfactory Disorders:** OR6S1's role in detecting odorants and transmitting this information to the brain makes it a potential target for the diagnosis and treatment of olfactory disorders, such as anosmia and hyposmia. 2. **Cardiovascular Disease:** OR6S1's expression in cardiac endothelial cells suggests its potential involvement in cardiovascular disease, including hypertension and atherosclerosis. 3. **Renal Disease:** OR6S1's expression in renal cells highlights its potential role in regulating renal function and disease, including kidney failure and hypertension. 4. **Cancer Research:** OR6S1's presence in intestinal crypt stem cells and goblet cells suggests its potential involvement in cancer development and progression, particularly in gastrointestinal cancers. In conclusion, OR6S1 is a multifaceted gene that plays a crucial role in sensory perception, regulation of physiological processes, and potential involvement in various diseases. Further research is necessary to fully elucidate the functions and clinical significance of OR6S1, but its discovery highlights the complexity and diversity of the human olfactory system.

Genular Protein ID: 1258976198

Symbol: OR6S1_HUMAN

Name: Olfactory receptor 6S1

UniProtKB Accession Codes:

Q8NH40 Q6IFJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 331
  • Mass: 36127
  • Checksum: D7C1C3F266B336AB
  • Sequence:
    • MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV VRADTRLQTP 
MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI TQFYFYFFLG ASEFLLLAVM 
SADRYLAICH PLRYPLLMSG AVCFRVALAC WVGGLVPVLG PTVAVALLPF CKQGAVVQHF 
FCDSGPLLRL ACTNTKKLEE TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA 
FSTCTSHLIV VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV 
KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.