Details for: IFNA11P

Gene ID: 3461

Symbol: IFNA11P

Ensembl ID: ENSG00000231195

Description: interferon alpha 11, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0577
    Cell Significance Index: 0.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0047
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0312
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0393
    Cell Significance Index: -1.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0433
    Cell Significance Index: -1.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0436
    Cell Significance Index: -1.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0476
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0486
    Cell Significance Index: -1.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0522
    Cell Significance Index: -0.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0641
    Cell Significance Index: -1.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0644
    Cell Significance Index: -1.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0645
    Cell Significance Index: -1.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0671
    Cell Significance Index: -1.4200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0683
    Cell Significance Index: -1.3900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0759
    Cell Significance Index: -0.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0835
    Cell Significance Index: -0.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0863
    Cell Significance Index: -1.0900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0886
    Cell Significance Index: -0.8600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0921
    Cell Significance Index: -1.3800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0987
    Cell Significance Index: -1.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0996
    Cell Significance Index: -1.1400
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1002
    Cell Significance Index: -1.1900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1015
    Cell Significance Index: -1.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1340
    Cell Significance Index: -1.2700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1768
    Cell Significance Index: -1.1500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1777
    Cell Significance Index: -1.6200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2606
    Cell Significance Index: -1.6400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2730
    Cell Significance Index: -1.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: IFNA11P is a non-functional copy of the interferon alpha 11 gene, which implies that it does not possess the typical function of its parent gene. 2. **Wide expression**: IFNA11P is expressed in a diverse range of cells within the CNS, including those involved in myelination, neuronal communication, and immune responses. 3. **Cell-type specificity**: The expression of IFNA11P is cell-type specific, with distinct patterns of expression observed in different cell types within the CNS. 4. **Evolutionary conservation**: IFNA11P has been conserved across species, suggesting that it has retained functional significance despite its pseudogene status. **Pathways and Functions:** 1. **Regulation of immune responses**: Although IFNA11P is a pseudogene, it may still influence immune responses within the CNS, potentially modulating the activity of immune cells such as microglia and astrocytes. 2. **Development and maintenance of CNS cells**: IFNA11P may play a role in the development, maintenance, and function of CNS cells, including oligodendrocytes, neurons, and astrocytes. 3. **Neuroinflammation**: IFNA11P may also contribute to neuroinflammation, a key feature of various neurological disorders, by regulating the expression of pro-inflammatory cytokines and chemokines. 4. **Stem cell maintenance**: IFNA11P may influence the maintenance of stem cells within the CNS, potentially regulating their self-renewal and differentiation capacities. **Clinical Significance:** 1. **Neurological disorders**: The expression of IFNA11P in various CNS cells suggests that it may play a role in the development and progression of neurological disorders, such as multiple sclerosis, Alzheimer's disease, and Parkinson's disease. 2. **CNS development and regeneration**: IFNA11P may also contribute to the development and regeneration of CNS cells, potentially providing new avenues for therapeutic interventions. 3. **Immunotherapy**: Understanding the function of IFNA11P in the CNS may lead to the development of novel immunotherapeutic strategies for treating neurological disorders. 4. **CNS stem cell biology**: The role of IFNA11P in maintaining CNS stem cells may have implications for our understanding of stem cell biology and the development of regenerative therapies for CNS disorders. In conclusion, the IFNA11P pseudogene has been found to be expressed in a wide range of cells within the CNS, suggesting that it may play a crucial role in the development, maintenance, and function of these cells. Further research is needed to elucidate the function of IFNA11P and its potential role in neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.