Details for: MIR199A2

Gene ID: 406977

Symbol: MIR199A2

Ensembl ID: ENSG00000208024

Description: microRNA 199a-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1802
    Cell Significance Index: 2.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0183
    Cell Significance Index: 0.4900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0039
    Cell Significance Index: 0.0400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0104
    Cell Significance Index: -0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0137
    Cell Significance Index: -0.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0142
    Cell Significance Index: -0.3100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0325
    Cell Significance Index: -0.3700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0329
    Cell Significance Index: -0.3800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0351
    Cell Significance Index: -0.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0466
    Cell Significance Index: -0.5500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0470
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0480
    Cell Significance Index: -0.5700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0664
    Cell Significance Index: -0.7600
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0726
    Cell Significance Index: -0.3500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0734
    Cell Significance Index: -0.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0777
    Cell Significance Index: -0.9800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0779
    Cell Significance Index: -0.5400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0789
    Cell Significance Index: -1.0300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0836
    Cell Significance Index: -0.8900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0852
    Cell Significance Index: -0.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0854
    Cell Significance Index: -0.9300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0868
    Cell Significance Index: -1.0200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0893
    Cell Significance Index: -1.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0905
    Cell Significance Index: -0.9700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1013
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1036
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1365
    Cell Significance Index: -1.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1429
    Cell Significance Index: -1.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1573
    Cell Significance Index: -1.9100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1709
    Cell Significance Index: -1.9300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2161
    Cell Significance Index: -1.9000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2403
    Cell Significance Index: -1.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2446
    Cell Significance Index: -2.3200
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.4420
    Cell Significance Index: -1.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR199A2 is a 22-nucleotide long non-coding RNA that is highly conserved across species. It is a member of the miR-199 family, which is characterized by its ability to regulate gene expression post-transcriptionally. MIR199A2 is primarily expressed in cells that require rapid differentiation and proliferation, such as chondrocytes and smooth muscle myoblasts. Its expression is also observed in cells of the immune system, including lymphoid lineage-restricted progenitor cells and pericytes. **Pathways and Functions** MIR199A2 regulates gene expression through the miRISC (microRNA-induced silencing complex) pathway, which involves the binding of MIR199A2 to its target mRNAs, leading to their degradation or repression of translation. The miRISC pathway is involved in regulating various cellular processes, including cell growth, differentiation, and apoptosis. MIR199A2 has been shown to target genes involved in cell migration, adhesion, and survival, suggesting its role in regulating cellular behavior. **Clinical Significance** MIR199A2 has been implicated in various diseases, including cancer, cardiovascular disease, and autoimmune disorders. Its dysregulation has been observed in several types of cancer, including breast, lung, and colon cancer, where it is associated with tumor progression and metastasis. In cardiovascular disease, MIR199A2 has been shown to regulate smooth muscle cell proliferation and migration, which are critical components of atherosclerosis development. Additionally, MIR199A2 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune cell function and tissue damage. In conclusion, MIR199A2 is a critical regulator of cellular differentiation, proliferation, and survival, and its dysregulation has significant implications for human disease. Further studies are needed to fully elucidate the mechanisms by which MIR199A2 regulates cellular behavior and to explore its potential as a therapeutic target for various diseases. **Clinical Implications and Future Directions** The dysregulation of MIR199A2 has been observed in several diseases, and its clinical significance is increasingly recognized. Future studies should focus on: 1. Elucidating the molecular mechanisms by which MIR199A2 regulates cellular behavior. 2. Investigating the role of MIR199A2 in disease pathogenesis and progression. 3. Developing novel therapeutic strategies that target MIR199A2 or its downstream targets. 4. Exploring the potential of MIR199A2 as a biomarker for disease diagnosis and monitoring. By advancing our understanding of MIR199A2 and its role in human disease, we can develop more effective treatments and improve patient outcomes.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.