Details for: TRGJ2

Gene ID: 6969

Symbol: TRGJ2

Ensembl ID: ENSG00000211687

Description: T cell receptor gamma joining 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.7333
    Cell Significance Index: 21.9000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.5630
    Cell Significance Index: 7.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0405
    Cell Significance Index: 0.4100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0144
    Cell Significance Index: 0.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0079
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0144
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0161
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0193
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0202
    Cell Significance Index: -0.3900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0207
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0273
    Cell Significance Index: -0.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0276
    Cell Significance Index: -0.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0282
    Cell Significance Index: -0.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0286
    Cell Significance Index: -0.3800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0307
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0358
    Cell Significance Index: -0.3400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0384
    Cell Significance Index: -0.3200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0397
    Cell Significance Index: -0.3500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0398
    Cell Significance Index: -0.3600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0404
    Cell Significance Index: -0.4100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0405
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0419
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0434
    Cell Significance Index: -0.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0462
    Cell Significance Index: -0.4100
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0488
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0537
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGJ2 is a gene that encodes for a protein with an unclear function, but its expression is widespread across different cell types, including those involved in the adaptive and innate immune responses. It is also notable for its involvement in the development and function of T cells, a crucial component of the adaptive immune system. The gene's expression is significantly elevated in various cell types, including plasma cells, T cells, B cells, leukocytes, and innate lymphoid cells, highlighting its potential role in immune regulation and modulation. **Pathways and Functions:** While the exact function of TRGJ2 remains unclear, its expression and localization suggest that it may play a role in the regulation of immune cell function and signaling pathways. Several key pathways are implicated in TRGJ2's functions, including: 1. **T cell receptor signaling:** TRGJ2 is expressed in T cells, suggesting that it may be involved in the regulation of T cell receptor signaling and the subsequent activation of immune responses. 2. **Immune cell adhesion:** TRGJ2 is also expressed in leukocytes and other immune cells, which may indicate its role in the regulation of immune cell adhesion and migration. 3. **Innate immune response:** TRGJ2's expression in innate lymphoid cells suggests that it may play a role in the regulation of the innate immune response and the initiation of adaptive immune responses. **Clinical Significance:** TRGJ2's expression in various cell types and its involvement in immune regulation and modulation suggest that it may have significant clinical implications. Some potential applications of TRGJ2 include: 1. **Immunotherapy:** TRGJ2's role in regulating immune cell function and signaling pathways may make it a potential target for immunotherapeutic interventions, such as checkpoint inhibitors or cytokine therapies. 2. **Autoimmune diseases:** TRGJ2's involvement in immune cell regulation and modulation may also suggest a role in autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer immunotherapy:** TRGJ2's expression in various cell types, including cancer cells, may also suggest a role in cancer immunotherapy, such as the activation of immune cells against cancer cells. In conclusion, TRGJ2 is a gene with complex and multifaceted functions, and its expression in various cell types highlights its potential role in immune regulation and modulation. Further research is needed to fully elucidate TRGJ2's functions and its clinical significance, but its potential applications in immunotherapy, autoimmune disease treatment, and cancer immunotherapy make it an exciting area of investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.