Details for: LOC100506489

Gene ID: 100506489

Symbol: LOC100506489

Ensembl ID: ENSG00000240973

Description: uncharacterized LOC100506489

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1545
    Cell Significance Index: 1.5800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0876
    Cell Significance Index: 0.7200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0310
    Cell Significance Index: 0.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0298
    Cell Significance Index: 0.6500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0213
    Cell Significance Index: 0.2300
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.0168
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0052
    Cell Significance Index: 0.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0049
    Cell Significance Index: 0.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0036
    Cell Significance Index: 0.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0013
    Cell Significance Index: -0.0300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0024
    Cell Significance Index: -0.0800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0069
    Cell Significance Index: -0.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0099
    Cell Significance Index: -0.0800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0110
    Cell Significance Index: -0.1400
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0120
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0147
    Cell Significance Index: -0.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0164
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0171
    Cell Significance Index: -0.2200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0193
    Cell Significance Index: -0.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0200
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0243
    Cell Significance Index: -0.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The LOC100506489 gene exhibits a unique expression profile, with significant expression in various cell types, including: 1. Progenitor cells: These cells have the potential to differentiate into multiple cell types, suggesting a role in cellular development and differentiation. 2. Oligodendrocyte precursor cells: These cells are responsible for myelinating neurons in the central nervous system, implying a potential role in neurodevelopment and myelination. 3. Leukocytes: White blood cells are crucial for immune responses, and the expression of LOC100506489 in these cells may indicate a role in immune function or regulation. 4. Cajal-Retzius cells: These cells are involved in the development of the cerebral cortex and may play a role in neuronal development and patterning. 5. Cerebral cortex endothelial cells: These cells form the blood-brain barrier, suggesting a potential role in maintaining the integrity of the central nervous system. 6. Microglial cells: These cells are involved in immune surveillance and may play a role in regulating immune responses in the central nervous system. 7. Intestinal enteroendocrine cells: These cells are responsible for producing hormones involved in digestion and metabolism, implying a potential role in regulating gastrointestinal function. 8. Fibroblasts: These cells are involved in wound healing and tissue repair, suggesting a potential role in fibrosis or tissue remodeling. 9. Blood vessel endothelial cells: These cells form the lining of blood vessels and may play a role in regulating vascular function and blood pressure. **Pathways and Functions:** Based on its expression profile, LOC100506489 may be involved in various cellular processes, including: 1. Cell signaling: The expression of LOC100506489 in leukocytes and endothelial cells suggests a role in cell signaling pathways, such as the JAK/STAT or MAPK signaling pathways. 2. Developmental processes: The expression of LOC100506489 in progenitor cells, oligodendrocyte precursor cells, and Cajal-Retzius cells implies a role in neurodevelopment and cellular differentiation. 3. Immune regulation: The expression of LOC100506489 in leukocytes and microglial cells suggests a role in regulating immune responses and maintaining immune homeostasis. 4. Tissue repair: The expression of LOC100506489 in fibroblasts and endothelial cells implies a role in wound healing and tissue repair. **Clinical Significance:** The discovery of LOC100506489 raises several questions about its clinical significance. Potential applications of this gene include: 1. Understanding neurodevelopmental disorders: The expression of LOC100506489 in oligodendrocyte precursor cells and Cajal-Retzius cells suggests a potential role in neurodevelopmental disorders, such as autism or schizophrenia. 2. Regulating immune responses: The expression of LOC100506489 in leukocytes and microglial cells implies a potential role in regulating immune responses and maintaining immune homeostasis, which could be relevant in autoimmune disorders or cancer. 3. Developing new therapeutic strategies: The identification of LOC100506489 as a potential therapeutic target could lead to the development of new treatments for various diseases, including neurodevelopmental disorders and autoimmune disorders. In conclusion, while the functional significance of LOC100506489 remains elusive, its widespread expression in various cell types suggests a complex role in cellular development, immune regulation, and tissue repair. Further research is needed to elucidate the mechanisms by which this gene functions and to explore its potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.