Details for: TAAR9

Gene ID: 134860

Symbol: TAAR9

Ensembl ID: ENSG00000237110

Description: trace amine associated receptor 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0913
    Cell Significance Index: 1.0500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0120
    Cell Significance Index: 0.1400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0115
    Cell Significance Index: 0.1100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0019
    Cell Significance Index: -0.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0145
    Cell Significance Index: -2.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0176
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0195
    Cell Significance Index: -0.2100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0437
    Cell Significance Index: -0.8700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0506
    Cell Significance Index: -0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0506
    Cell Significance Index: -0.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0678
    Cell Significance Index: -1.4400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0704
    Cell Significance Index: -0.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1252
    Cell Significance Index: -0.7400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1292
    Cell Significance Index: -1.6300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1426
    Cell Significance Index: -1.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1517
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1556
    Cell Significance Index: -1.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1684
    Cell Significance Index: -2.0700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1705
    Cell Significance Index: -2.0400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1714
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1770
    Cell Significance Index: -1.4000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1924
    Cell Significance Index: -2.0800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2345
    Cell Significance Index: -2.1100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2435
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2956
    Cell Significance Index: -2.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3067
    Cell Significance Index: -1.6400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3187
    Cell Significance Index: -2.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAAR9 is a member of the TAAR family, which consists of receptors that respond to endogenous and exogenous amines. The receptor exhibits a high degree of sequence homology with other TAARs, including TAAR1 and TAAR6, and shares structural similarities with rhodopsin-like GPCRs. TAAR9 is characterized by its ability to bind to trace amines, such as tyramine and phenethylamine, which are endogenous neurotransmitters and neuromodulators. The receptor's ligand-binding properties and signaling mechanisms are distinct from other GPCRs, suggesting a unique role in modulating immune responses. **Pathways and Functions:** TAAR9 is involved in various signaling pathways, including Gαs signaling events, GPCR downstream signaling, and GPCR ligand binding. The receptor's activation by trace amines leads to the activation of Gαs proteins, which in turn stimulate adenylate cyclase activity, resulting in increased cAMP levels. This increase in cAMP levels triggers various downstream signaling events, including the activation of protein kinase A (PKA) and the modulation of ion channels. The functional consequences of TAAR9 activation are far-reaching, with implications for immune homeostasis and tissue function. In immune cells, TAAR9 activation has been shown to modulate the production of cytokines and chemokines, influencing the development and function of immune responses. Additionally, TAAR9 has been implicated in the regulation of smooth muscle contraction and relaxation, highlighting its role in cardiovascular and gastrointestinal physiology. **Clinical Significance:** TAAR9 has significant clinical implications, particularly in the context of immune-mediated disorders. Dysregulation of TAAR9 signaling has been implicated in various diseases, including autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. The receptor's role in modulating immune responses suggests that TAAR9 may serve as a therapeutic target for the treatment of immune-related diseases. Furthermore, TAAR9 has been implicated in the pathophysiology of neurological disorders, including Parkinson's disease and schizophrenia. The receptor's ability to modulate neurotransmitter release and synaptic plasticity suggests that TAAR9 may play a role in the development and progression of these diseases. In conclusion, TAAR9 is a novel immunomodulatory receptor that plays a critical role in regulating immune responses and modulating physiological processes. Further research is needed to fully elucidate the receptor's functions and clinical significance, but the available evidence highlights the potential of TAAR9 as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 1469631144

Symbol: TAAR9_HUMAN

Name: Trace amine-associated receptor 9

UniProtKB Accession Codes:

Q96RI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11459929

Title: Trace amines: identification of a family of mammalian G protein-coupled receptors.

PubMed ID: 11459929

DOI: 10.1073/pnas.151105198

Sequence Information:

  • Length: 348
  • Mass: 39016
  • Checksum: D0C6484880A6F761
  • Sequence:
    • MVNNFSQAEA VELCYKNVNE SCIKTPYSPG PRSILYAVLG FGAVLAAFGN LLVMIAILHF 
KQLHTPTNFL IASLACADFL VGVTVMPFST VRSVESCWYF GDSYCKFHTC FDTSFCFASL 
FHLCCISVDR YIAVTDPLTY PTKFTVSVSG ICIVLSWFFS VTYSFSIFYT GANEEGIEEL 
VVALTCVGGC QAPLNQNWVL LCFLLFFIPN VAMVFIYSKI FLVAKHQARK IESTASQAQS 
SSESYKERVA KRERKAAKTL GIAMAAFLVS WLPYLVDAVI DAYMNFITPP YVYEILVWCV 
YYNSAMNPLI YAFFYQWFGK AIKLIVSGKV LRTDSSTTNL FSEEVETD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.