Details for: SNORD60

Gene ID: 26788

Symbol: SNORD60

Ensembl ID: ENSG00000206630

Description: small nucleolar RNA, C/D box 60

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1330
    Cell Significance Index: 1.8900
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0061
    Cell Significance Index: 0.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0053
    Cell Significance Index: 0.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0009
    Cell Significance Index: -0.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0050
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0085
    Cell Significance Index: -0.0700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0120
    Cell Significance Index: -0.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0142
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0202
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0232
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0245
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0246
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0252
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0254
    Cell Significance Index: -0.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0261
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0266
    Cell Significance Index: -0.2600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0272
    Cell Significance Index: -0.3200
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0279
    Cell Significance Index: -0.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0286
    Cell Significance Index: -0.2200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0333
    Cell Significance Index: -0.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0552
    Cell Significance Index: -0.7700
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0560
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0674
    Cell Significance Index: -0.6400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0769
    Cell Significance Index: -0.9300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0796
    Cell Significance Index: -0.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0825
    Cell Significance Index: -1.3900
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1046
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1364
    Cell Significance Index: -1.2800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1419
    Cell Significance Index: -1.4500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1565
    Cell Significance Index: -1.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD60 belongs to the snoRNA family, which plays a crucial role in RNA processing, particularly in the modification of ribosomal RNA (rRNA) and other small RNAs. The C/D box motif present in SNORD60 is a characteristic feature of snoRNAs involved in rRNA methylation and pseudouridylation. This snoRNA is expressed in a wide range of cell types, including pericytes, cardiac endothelial cells, and lymphoid lineage-restricted progenitor cells, suggesting its involvement in cellular differentiation and development. **Pathways and Functions:** SNORD60 is involved in RNA processing pathways, specifically in the modification of rRNA and other small RNAs. The C/D box motif of SNORD60 recognizes and binds to specific sequences on target RNAs, facilitating the catalytic activity of the associated protein (Nop1) to perform methylation and pseudouridylation reactions. These modifications are crucial for rRNA biogenesis, translation efficiency, and the regulation of gene expression. In addition to its role in RNA processing, SNORD60 has been implicated in cellular differentiation and development. Its expression in various cell types suggests that it may play a role in regulating cellular behavior, including proliferation, differentiation, and survival. The involvement of SNORD60 in the differentiation of cardiac muscle myoblasts and smooth muscle myoblasts is particularly noteworthy, as it highlights its potential role in cardiovascular development and disease. **Clinical Significance:** The clinical significance of SNORD60 is still unclear, but its expression in various cell types and its involvement in RNA processing and cellular differentiation pathways suggest that it may play a role in human diseases. For example, alterations in SNORD60 expression have been observed in certain types of cancer, such as colon cancer, where it may contribute to tumorigenesis. Additionally, the involvement of SNORD60 in cardiovascular development and disease highlights its potential role in cardiovascular disorders, such as heart failure and arrhythmias. In conclusion, SNORD60 is a small nucleolar RNA with a C/D box motif that plays a crucial role in RNA processing and cellular differentiation. Further research is necessary to elucidate the functional mechanisms of SNORD60 and its implications in human diseases. Its involvement in various cell types and its expression in different tissues suggest that it may play a role in regulating cellular behavior and maintaining cellular homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.