Details for: SNORD58B

Gene ID: 26790

Symbol: SNORD58B

Ensembl ID: ENSG00000271982

Description: small nucleolar RNA, C/D box 58B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1083
    Cell Significance Index: 1.1200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0257
    Cell Significance Index: 0.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0231
    Cell Significance Index: 0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0156
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0207
    Cell Significance Index: -0.2700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0218
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0230
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0238
    Cell Significance Index: -0.2600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0258
    Cell Significance Index: -0.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0284
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0346
    Cell Significance Index: -0.2400
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0458
    Cell Significance Index: -0.2200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1523
    Cell Significance Index: -1.7200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1859
    Cell Significance Index: -2.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2025
    Cell Significance Index: -2.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2091
    Cell Significance Index: -2.4900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2406
    Cell Significance Index: -3.0200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2408
    Cell Significance Index: -3.0100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2549
    Cell Significance Index: -2.7400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2888
    Cell Significance Index: -2.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2975
    Cell Significance Index: -3.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3476
    Cell Significance Index: -2.8700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.3542
    Cell Significance Index: -3.8300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3664
    Cell Significance Index: -2.8200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4081
    Cell Significance Index: -4.4500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.4290
    Cell Significance Index: -4.2300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4531
    Cell Significance Index: -4.6200
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4672
    Cell Significance Index: -4.3800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.5002
    Cell Significance Index: -4.7500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5072
    Cell Significance Index: -4.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD58B belongs to the snoRNA family, which is characterized by their ability to bind to specific RNA sequences and regulate RNA processing. The C/D box motif present in SNORD58B is a hallmark of snoRNAs, allowing them to interact with the ribosomal RNA (rRNA) and other non-coding RNAs. This interaction enables SNORD58B to modulate RNA processing, including the regulation of rRNA methylation and the formation of ribonucleoprotein (RNP) complexes. Furthermore, SNORD58B has been shown to be involved in the regulation of alternative splicing and the modulation of gene expression. **Pathways and Functions:** The pathways and functions of SNORD58B are multifaceted and far-reaching. In the context of RNA processing, SNORD58B plays a critical role in regulating rRNA methylation, which is essential for ribosome biogenesis and function. Additionally, SNORD58B has been implicated in the regulation of alternative splicing, a process that allows for the generation of diverse protein isoforms. This, in turn, can influence cellular differentiation, proliferation, and survival. Furthermore, SNORD58B has been shown to interact with other non-coding RNAs, including microRNAs and long non-coding RNAs, to modulate gene expression and regulate cellular processes. **Clinical Significance:** The clinical significance of SNORD58B is an area of active research, with potential implications for various diseases. Given its expression in a range of cell types, including those involved in cardiovascular disease, cancer, and neurological disorders, SNORD58B may play a role in the pathogenesis of these conditions. For example, dysregulation of SNORD58B expression has been linked to cardiovascular disease, including atherosclerosis and cardiac hypertrophy. Additionally, SNORD58B has been implicated in the regulation of immune responses, including the modulation of innate and adaptive immunity. Further research is needed to fully elucidate the clinical significance of SNORD58B and its potential as a therapeutic target. In conclusion, SNORD58B is a small nucleolar RNA with multifaceted functions in RNA processing, cellular differentiation, and gene regulation. Its expression in a diverse range of cell types highlights its potential involvement in various physiological and pathological processes. Further research is needed to fully elucidate the clinical significance of SNORD58B and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.