Details for: SNORD57

Gene ID: 26792

Symbol: SNORD57

Ensembl ID: ENSG00000226572

Description: small nucleolar RNA, C/D box 57

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0186
    Cell Significance Index: 10.5500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.3543
    Cell Significance Index: 4.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0942
    Cell Significance Index: 1.2100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0703
    Cell Significance Index: 0.9700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0446
    Cell Significance Index: 0.5600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0331
    Cell Significance Index: 0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0038
    Cell Significance Index: -1.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0327
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0441
    Cell Significance Index: -0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0457
    Cell Significance Index: -1.0000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0594
    Cell Significance Index: -0.7500
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0663
    Cell Significance Index: -0.4600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0711
    Cell Significance Index: -0.9600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0849
    Cell Significance Index: -0.9100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0873
    Cell Significance Index: -1.1400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0978
    Cell Significance Index: -1.1500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0997
    Cell Significance Index: -1.1800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0998
    Cell Significance Index: -1.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1014
    Cell Significance Index: -1.1600
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.2343
    Cell Significance Index: -1.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2634
    Cell Significance Index: -3.1400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3197
    Cell Significance Index: -4.0100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.3216
    Cell Significance Index: -4.0300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3307
    Cell Significance Index: -4.1300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3653
    Cell Significance Index: -4.8500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4170
    Cell Significance Index: -4.7100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4492
    Cell Significance Index: -5.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4618
    Cell Significance Index: -5.6000
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.4768
    Cell Significance Index: -1.1400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5100
    Cell Significance Index: -4.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5110
    Cell Significance Index: -3.9300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5202
    Cell Significance Index: -5.5900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5770
    Cell Significance Index: -5.6900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5824
    Cell Significance Index: -5.9400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.6207
    Cell Significance Index: -5.7000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6217
    Cell Significance Index: -5.4800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.6387
    Cell Significance Index: -6.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **C/D box snoRNA**: SNORD57 is a member of the C/D box snoRNA family, characterized by the presence of a C/D box motif (C: C-rich; D: D-rich) in its secondary structure. 2. **Widespread expression**: SNORD57 is significantly expressed in various cell types, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, and immune cells such as immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells. 3. **Nucleolus and RNA processing**: SNORD57 is localized to the nucleolus, a region responsible for ribosomal RNA synthesis and processing. Its expression is associated with RNA processing pathways, suggesting a role in regulating gene expression. 4. **Cell-type specific expression**: The expression of SNORD57 varies across different cell types, with some cells exhibiting high levels of expression and others showing minimal or no detectable levels. **Pathways and Functions:** 1. **RNA processing and modification**: SNORD57 is involved in RNA processing and modification, particularly in the context of ribosomal RNA synthesis and processing. Its expression may influence the regulation of gene expression, potentially affecting cellular functions such as proliferation, differentiation, and survival. 2. **Immune cell development and function**: SNORD57's expression in immune cells suggests a role in the development and function of these cells. Its involvement in RNA processing and modification may influence the regulation of immune-related genes, such as those involved in cytokine production and immune cell activation. 3. **Cardiac tissue development and function**: SNORD57's expression in cardiac endothelial cells, cardiac muscle myoblasts, and fibroblasts of cardiac tissue suggests a role in cardiac tissue development and function. Its involvement in RNA processing and modification may influence the regulation of cardiac-specific genes, such as those involved in cardiac contraction and relaxation. **Clinical Significance:** 1. **Immune-related disorders**: SNORD57's expression in immune cells and its involvement in RNA processing and modification suggest a potential role in immune-related disorders, such as autoimmune diseases, immunodeficiency disorders, and cancer. 2. **Cardiac diseases**: SNORD57's expression in cardiac tissue and its involvement in RNA processing and modification may contribute to the development and progression of cardiac diseases, such as heart failure, arrhythmias, and cardiomyopathy. 3. **Cancer**: SNORD57's expression in various cell types, including immune cells and cancer cells, suggests a potential role in cancer development and progression. Its involvement in RNA processing and modification may influence the regulation of tumor suppressor genes and oncogenes. In conclusion, SNORD57 is a small nucleolar RNA with significant implications for our understanding of immune and non-immune cell biology. Further research is needed to fully elucidate its functions and clinical significance, but its widespread expression and involvement in RNA processing and modification make it an exciting area of investigation for immunologists and clinicians.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.