Details for: RNU2 3P

Gene ID: 26854

Symbol: RNU2 3P

Ensembl ID: ENSG00000222076

Description: RNA, U2 small nuclear 3, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.3544
    Cell Significance Index: 4.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1193
    Cell Significance Index: 1.1800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1000
    Cell Significance Index: 1.4600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0253
    Cell Significance Index: 0.2500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0130
    Cell Significance Index: 0.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0074
    Cell Significance Index: 0.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0111
    Cell Significance Index: -0.1500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0141
    Cell Significance Index: -0.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0141
    Cell Significance Index: -0.1500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0188
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0192
    Cell Significance Index: -0.1600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0219
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1658
    Cell Significance Index: -1.6900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2117
    Cell Significance Index: -2.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2407
    Cell Significance Index: -3.2000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2434
    Cell Significance Index: -2.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2552
    Cell Significance Index: -2.7800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2853
    Cell Significance Index: -3.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2877
    Cell Significance Index: -3.6300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2968
    Cell Significance Index: -3.3200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3304
    Cell Significance Index: -4.5400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3497
    Cell Significance Index: -3.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3688
    Cell Significance Index: -4.6700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3728
    Cell Significance Index: -4.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3740
    Cell Significance Index: -4.2800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3751
    Cell Significance Index: -4.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3867
    Cell Significance Index: -4.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3885
    Cell Significance Index: -4.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4287
    Cell Significance Index: -4.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4467
    Cell Significance Index: -4.2900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.4794
    Cell Significance Index: -4.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.5416
    Cell Significance Index: -4.2100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.5829
    Cell Significance Index: -4.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic Nature:** RNU2 3P is a pseudogene, meaning it lacks a functional coding sequence and does not produce a protein. However, its expression and regulatory elements suggest that it may have evolved from a functional gene. 2. **Widespread Expression:** This pseudogene is significantly expressed in various cell types, including neural and immune cells, indicating its potential role in cellular differentiation and immune regulation. 3. **Cell-type Specificity:** The expression of RNU2 3P is cell-type specific, with varying levels of expression observed across different cell types. This specificity suggests that the gene may play a role in regulating cellular differentiation and function. **Pathways and Functions:** While the exact mechanisms of RNU2 3P are not fully understood, several pathways and functions have been proposed based on its expression and regulatory elements: 1. **Immune Regulation:** RNU2 3P may play a role in regulating immune responses, particularly in the context of neural and glial cells. Its expression in immune cells and stromal cells suggests that it may be involved in modulating immune cell function and promoting tissue homeostasis. 2. **Cellular Differentiation:** The expression of RNU2 3P in neural progenitor cells and glial cells suggests that it may play a role in regulating cellular differentiation and development. Its presence in GABAergic and glutamatergic neurons indicates that it may also be involved in the development of these neuronal populations. 3. **Non-coding RNA-mediated Regulation:** RNU2 3P may act as a non-coding RNA, influencing gene expression through RNA-binding proteins or other mechanisms. Its regulatory elements, such as enhancers and silencers, suggest that it may play a role in regulating gene expression at the level of transcription. **Clinical Significance:** While the clinical significance of RNU2 3P is not yet fully understood, its expression in various cell types and its potential role in immune regulation and cellular differentiation suggest that it may be involved in several human diseases: 1. **Neurological Disorders:** The expression of RNU2 3P in neural cells and its potential role in regulating cellular differentiation and immune responses may make it a candidate gene for studying neurological disorders, such as multiple sclerosis, Parkinson's disease, and Alzheimer's disease. 2. **Immune-related Disorders:** The expression of RNU2 3P in immune cells and its potential role in regulating immune responses may make it a candidate gene for studying immune-related disorders, such as autoimmune diseases, cancer, and infectious diseases. 3. **Cancer:** The expression of RNU2 3P in stromal cells and its potential role in regulating cellular differentiation and immune responses may make it a candidate gene for studying cancer development and progression. In conclusion, RNU2 3P is a pseudogene with a hidden role in immune regulation and cellular differentiation. Further research is needed to fully understand its mechanisms of action and clinical significance, but its expression in various cell types and potential role in regulating gene expression make it an intriguing candidate for studying human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.