Details for: TRAJ52

Gene ID: 28703

Symbol: TRAJ52

Ensembl ID: ENSG00000211838

Description: T cell receptor alpha joining 52

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0061
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0098
    Cell Significance Index: -0.1000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0100
    Cell Significance Index: -0.1000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0116
    Cell Significance Index: -0.0800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0118
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0128
    Cell Significance Index: -0.1300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0139
    Cell Significance Index: -0.1600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0139
    Cell Significance Index: -0.1300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0144
    Cell Significance Index: -0.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0148
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0151
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0162
    Cell Significance Index: -0.1400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0168
    Cell Significance Index: -0.1500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0169
    Cell Significance Index: -0.1700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0178
    Cell Significance Index: -0.1500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0183
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0198
    Cell Significance Index: -0.1600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0201
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0204
    Cell Significance Index: -0.1900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0206
    Cell Significance Index: -0.1600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0228
    Cell Significance Index: -0.1700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0299
    Cell Significance Index: -0.1600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0371
    Cell Significance Index: -0.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ52 is significantly expressed in various T cell subsets, including CD8-positive, alpha-beta T cells, double-positive, alpha-beta thymocytes, mature NK T cells, and effector memory CD8-positive, alpha-beta T cells. 2. **Genomic Location:** The TRAJ52 gene is located on chromosome 2q35.3, a region rich in immunoglobulin and TCR-related genes. 3. **Gene Structure:** The TRAJ52 gene consists of 6 exons, encoding a 345-amino acid protein with a unique structure, including a conserved domain and a C-terminal tail. **Pathways and Functions:** 1. **TCR Assembly:** TRAJ52 interacts with other TCR components, such as TRAJ21, TRAJ25, and TRAJ33, to form a functional TCR complex. This assembly process is crucial for T cell activation and antigen recognition. 2. **TCR Maturation:** TRAJ52 plays a key role in the maturation of T cells, ensuring the proper folding and assembly of the TCR complex. 3. **T Cell Activation:** TRAJ52 is involved in the signaling events that occur upon T cell activation, influencing the strength and duration of the immune response. 4. **Regulation of T Cell Development:** TRAJ52 may also regulate T cell development, influencing the expansion and differentiation of T cell subsets. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRAJ52 expression or function have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysregulation plays a key role. 2. **Cancer:** TRAJ52 may also contribute to cancer development, as aberrant TCR signaling can promote tumor growth and immune evasion. 3. **Infectious Diseases:** TRAJ52 is essential for effective immune responses to certain pathogens, such as HIV, where T cell dysfunction can lead to disease progression. 4. **Immunodeficiency Disorders:** Mutations in TRAJ52 can lead to impaired T cell development and function, resulting in immunodeficiency disorders, such as Severe Combined Immunodeficiency (SCID). In conclusion, TRAJ52 is a critical gene that plays a vital role in T cell development, maturation, and function. Understanding the complexities of TRAJ52 and its interactions with other TCR components is essential for unraveling the mechanisms underlying immune-related disorders and developing novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.