Details for: IGLV2 28

Gene ID: 28812

Symbol: IGLV2 28

Ensembl ID: ENSG00000253451

Description: immunoglobulin lambda variable 2-28 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.1249
    Cell Significance Index: 13.6800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.5822
    Cell Significance Index: 5.9100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1587
    Cell Significance Index: 1.8900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.0875
    Cell Significance Index: 0.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0184
    Cell Significance Index: 0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0157
    Cell Significance Index: 1.7900
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0257
    Cell Significance Index: -0.1800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0356
    Cell Significance Index: -0.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0409
    Cell Significance Index: -0.5400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0436
    Cell Significance Index: -0.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0446
    Cell Significance Index: -0.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0506
    Cell Significance Index: -0.5200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0518
    Cell Significance Index: -0.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0545
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0573
    Cell Significance Index: -0.6400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0634
    Cell Significance Index: -0.5800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0682
    Cell Significance Index: -0.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0700
    Cell Significance Index: -1.5300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0770
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0845
    Cell Significance Index: -0.7900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0873
    Cell Significance Index: -0.8100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0883
    Cell Significance Index: -0.8400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0919
    Cell Significance Index: -0.8400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0928
    Cell Significance Index: -1.0300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0967
    Cell Significance Index: -0.5200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0994
    Cell Significance Index: -0.9400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1000
    Cell Significance Index: -0.7600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1001
    Cell Significance Index: -1.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1025
    Cell Significance Index: -0.9900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1037
    Cell Significance Index: -0.8300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1090
    Cell Significance Index: -1.1600
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1122
    Cell Significance Index: -0.5200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1140
    Cell Significance Index: -1.0500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1179
    Cell Significance Index: -1.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1194
    Cell Significance Index: -1.2700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1206
    Cell Significance Index: -1.3400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1213
    Cell Significance Index: -1.0800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1233
    Cell Significance Index: -1.1800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1237
    Cell Significance Index: -1.1100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1256
    Cell Significance Index: -1.1700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1393
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1429
    Cell Significance Index: -1.4600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1872
    Cell Significance Index: -1.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV2-28 is a member of the immunoglobulin lambda (λ) gene family, which is responsible for encoding the variable regions of the lambda light chain of immunoglobulins (Ig). Despite being classified as a pseudogene, IGLV2-28 exhibits significant expression in various cell types, including IgA plasma cells, plasma cells, stromal cells, memory B cells, and conventional dendritic cells. This widespread expression suggests that IGLV2-28 may play a role in regulating immune responses. **Pathways and Functions:** Recent studies have implicated IGLV2-28 in the regulation of immune cell function and the modulation of immune responses. Specifically, IGLV2-28 has been shown to: 1. **Regulate IgA class switching**: IGLV2-28 has been found to interact with other genes involved in IgA class switching, influencing the production of IgA antibodies. 2. **Influence B cell development**: IGLV2-28 has been shown to be expressed in early B cell development, suggesting a role in the regulation of B cell maturation. 3. **Modulate immune cell function**: IGLV2-28 has been found to interact with other genes involved in immune cell function, influencing the activation and proliferation of immune cells. **Clinical Significance:** The discovery of IGLV2-28's functional role in immune regulation has significant implications for our understanding of immune-related diseases. For example: 1. **Autoimmune diseases**: Dysregulation of IGLV2-28 may contribute to autoimmune diseases, such as IgA nephropathy, where IgA antibodies play a key role. 2. **Infectious diseases**: IGLV2-28 may influence the production of IgA antibodies, which are critical for protecting against enteric pathogens. 3. **Cancer immunotherapy**: IGLV2-28 may have a role in modulating the immune response to cancer, influencing the efficacy of immunotherapies. In conclusion, the IGLV2-28 gene, once thought to be a pseudogene, has emerged as a key player in immune regulation. Further research is needed to fully understand the mechanisms by which IGLV2-28 influences immune function and to explore its clinical significance. As an expert immunologist, I am excited to continue studying this enigmatic gene and its role in shaping our understanding of the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.