Details for: ZNF117

Gene ID: 51351

Symbol: ZNF117

Ensembl ID: ENSG00000152926

Description: zinc finger protein 117

Associated with

  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.9581
    Cell Significance Index: -18.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.2274
    Cell Significance Index: -18.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.5886
    Cell Significance Index: -19.2200
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 14.4457
    Cell Significance Index: 18.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3460
    Cell Significance Index: -17.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9074
    Cell Significance Index: -19.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5321
    Cell Significance Index: -13.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.7872
    Cell Significance Index: 101.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7467
    Cell Significance Index: -8.2000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.8877
    Cell Significance Index: 23.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4879
    Cell Significance Index: 283.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.0694
    Cell Significance Index: 307.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9636
    Cell Significance Index: 156.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8550
    Cell Significance Index: 772.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8451
    Cell Significance Index: 47.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6974
    Cell Significance Index: 68.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5533
    Cell Significance Index: 60.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5203
    Cell Significance Index: 104.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4019
    Cell Significance Index: 24.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3830
    Cell Significance Index: 4.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3173
    Cell Significance Index: 19.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3100
    Cell Significance Index: 6.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2791
    Cell Significance Index: 14.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2732
    Cell Significance Index: 54.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2634
    Cell Significance Index: 18.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2535
    Cell Significance Index: 90.9200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1946
    Cell Significance Index: 1.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1868
    Cell Significance Index: 8.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1215
    Cell Significance Index: 7.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1012
    Cell Significance Index: 13.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0896
    Cell Significance Index: 4.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0896
    Cell Significance Index: 48.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0686
    Cell Significance Index: 3.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0683
    Cell Significance Index: 30.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0670
    Cell Significance Index: 5.1500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0643
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0526
    Cell Significance Index: 9.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0427
    Cell Significance Index: 80.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0347
    Cell Significance Index: 53.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0308
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0291
    Cell Significance Index: 53.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0282
    Cell Significance Index: 17.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0235
    Cell Significance Index: 1.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0196
    Cell Significance Index: 0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0144
    Cell Significance Index: 0.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0121
    Cell Significance Index: 5.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0014
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0068
    Cell Significance Index: -0.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0074
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0140
    Cell Significance Index: -2.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0211
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0219
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0304
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0312
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0351
    Cell Significance Index: -5.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0353
    Cell Significance Index: -1.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0387
    Cell Significance Index: -0.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0392
    Cell Significance Index: -2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0423
    Cell Significance Index: -5.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0427
    Cell Significance Index: -0.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0479
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0565
    Cell Significance Index: -6.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0643
    Cell Significance Index: -6.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0667
    Cell Significance Index: -8.6200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0874
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0932
    Cell Significance Index: -19.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1049
    Cell Significance Index: -12.0200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1238
    Cell Significance Index: -1.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1319
    Cell Significance Index: -1.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1418
    Cell Significance Index: -2.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1504
    Cell Significance Index: -3.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1545
    Cell Significance Index: -1.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1585
    Cell Significance Index: -16.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1599
    Cell Significance Index: -4.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1715
    Cell Significance Index: -5.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1809
    Cell Significance Index: -14.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1970
    Cell Significance Index: -6.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1972
    Cell Significance Index: -3.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2039
    Cell Significance Index: -5.5500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2124
    Cell Significance Index: -1.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2137
    Cell Significance Index: -5.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2183
    Cell Significance Index: -6.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2982
    Cell Significance Index: -18.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3106
    Cell Significance Index: -10.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3362
    Cell Significance Index: -3.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3434
    Cell Significance Index: -8.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3477
    Cell Significance Index: -5.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3531
    Cell Significance Index: -10.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3567
    Cell Significance Index: -11.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3605
    Cell Significance Index: -5.0600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3692
    Cell Significance Index: -5.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3708
    Cell Significance Index: -4.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF117 is a DNA-binding transcription factor that belongs to the zinc finger protein family. Its primary function is to regulate transcription by RNA polymerase II, which is a crucial step in the process of gene expression. The gene is specifically expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, and alpha-beta intraepithelial T cell. ZNF117 is also involved in the regulation of cis-regulatory regions of genes, which are essential for the proper expression of genes in specific cell types. **Pathways and Functions:** ZNF117 is involved in several key pathways, including: 1. **DNA-binding transcription factor activity**: ZNF117 binds to specific DNA sequences, regulating the expression of target genes. 2. **RNA polymerase II-specific transcription regulation**: ZNF117 regulates the expression of genes by interacting with RNA polymerase II, a crucial enzyme in the process of gene transcription. 3. **Regulation of DNA-templated transcription**: ZNF117 regulates the expression of genes by interacting with the DNA template, ensuring proper gene expression in specific cell types. 4. **Zinc ion binding**: ZNF117 binds to zinc ions, which is essential for its DNA-binding activity. **Clinical Significance:** The expression of ZNF117 in various cell types, including hematopoietic cells, T cells, and adipocytes, suggests its potential role in the regulation of hematopoiesis, immune cell development, and differentiation. Abnormal expression of ZNF117 may be associated with various diseases, including hematological disorders, immune-related disorders, and metabolic disorders. Further studies are needed to fully understand the role of ZNF117 in human disease and to explore its potential as a therapeutic target. In conclusion, ZNF117 is a transcriptional regulator that plays a critical role in the regulation of gene expression in various cell types, including hematopoietic cells, T cells, and adipocytes. Its expression in specific cell types suggests its potential role in the regulation of hematopoiesis, immune cell development, and differentiation. Further studies are needed to fully understand the role of ZNF117 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.