Details for: SNORA70

Gene ID: 26778

Symbol: SNORA70

Ensembl ID: ENSG00000207165

Description: small nucleolar RNA, H/ACA box 70

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0038
    Cell Significance Index: -1.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0207
    Cell Significance Index: -1.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0344
    Cell Significance Index: -0.3000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0396
    Cell Significance Index: -0.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0433
    Cell Significance Index: -0.4100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0452
    Cell Significance Index: -0.6100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0700
    Cell Significance Index: -0.8000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0721
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0746
    Cell Significance Index: -0.8000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0773
    Cell Significance Index: -0.9500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0820
    Cell Significance Index: -1.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0821
    Cell Significance Index: -0.9400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0910
    Cell Significance Index: -1.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0922
    Cell Significance Index: -1.0900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0925
    Cell Significance Index: -1.1000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0925
    Cell Significance Index: -1.0900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0930
    Cell Significance Index: -1.0800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0942
    Cell Significance Index: -1.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0957
    Cell Significance Index: -1.1300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0975
    Cell Significance Index: -1.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1028
    Cell Significance Index: -1.1200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1029
    Cell Significance Index: -1.1400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1083
    Cell Significance Index: -1.2300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1093
    Cell Significance Index: -1.3300
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1116
    Cell Significance Index: -1.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1172
    Cell Significance Index: -1.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1203
    Cell Significance Index: -1.0600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1248
    Cell Significance Index: -1.3200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1300
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1330
    Cell Significance Index: -1.1000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1339
    Cell Significance Index: -1.3100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1348
    Cell Significance Index: -1.3300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1384
    Cell Significance Index: -1.2800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1428
    Cell Significance Index: -1.3300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1428
    Cell Significance Index: -1.3300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1704
    Cell Significance Index: -1.3800
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.2094
    Cell Significance Index: -1.0100
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: -0.2439
    Cell Significance Index: -1.3400
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.4224
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Small nucleolar RNA**: SNORA70 is a small non-coding RNA, approximately 75 nucleotides in length, which is involved in the regulation of RNA processing. 2. **H/ACA box**: The H/ACA box is a specific sequence motif within the SNORA70 gene that is recognized by ribonucleoproteins (RNPs) and plays a crucial role in the processing of ribosomal RNA. 3. **Significant expression in various cell types**: SNORA70 is expressed in a wide range of cell types, including pericytes, cardiac endothelial cells, and lymphoid lineage-restricted progenitor cells. 4. **Involvement in RNA processing**: SNORA70 regulates the processing of ribosomal RNA, which is essential for protein synthesis and cellular function. **Pathways and Functions:** 1. **RNA processing**: SNORA70 regulates the processing of ribosomal RNA, which is crucial for protein synthesis and cellular function. 2. **Gene expression regulation**: SNORA70 modulates gene expression by influencing the processing of ribosomal RNA and the regulation of transcription factors. 3. **Cellular signaling pathways**: SNORA70 is involved in the regulation of cellular signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. 4. **Nucleolus**: SNORA70 is localized to the nucleolus, where it regulates the processing of ribosomal RNA and the assembly of ribosomes. **Clinical Significance:** The dysregulation of SNORA70 has been implicated in various diseases, including: 1. **Cardiovascular diseases**: SNORA70 has been shown to play a role in the regulation of cardiac function and the development of cardiovascular diseases, such as heart failure and atherosclerosis. 2. **Cancer**: SNORA70 has been implicated in the regulation of gene expression and the development of cancer, including lymphoid lineage-restricted cancers. 3. **Neurological disorders**: SNORA70 has been shown to play a role in the regulation of neuronal function and the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SNORA70 is a small non-coding RNA that plays a crucial role in the regulation of RNA processing, gene expression, and cellular signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this enigmatic gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.