Details for: OR4C12

Gene ID: 283093

Symbol: OR4C12

Ensembl ID: ENSG00000221954

Description: olfactory receptor family 4 subfamily C member 12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 4.33
    Marker Score: 1571
  • Cell Name: podocyte (CL0000653)
    Fold Change: 4.26
    Marker Score: 1573
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.99
    Marker Score: 1573
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.98
    Marker Score: 1572
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 2.89
    Marker Score: 1556
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.67
    Marker Score: 1560
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.52
    Marker Score: 1572
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.38
    Marker Score: 1569
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.04
    Marker Score: 1571
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.75
    Marker Score: 1573
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.55
    Marker Score: 1570
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.48
    Marker Score: 1567
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.42
    Marker Score: 1129
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.41
    Marker Score: 1571
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.33
    Marker Score: 1553
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.21
    Marker Score: 1572
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7670.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.14
    Marker Score: 1572
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.11
    Marker Score: 1572
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.09
    Marker Score: 1985
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.97
    Marker Score: 1571
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29696
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.94
    Marker Score: 859
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4802
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.83
    Marker Score: 5014.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.75
    Marker Score: 1559
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.68
    Marker Score: 2402
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1566
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.58
    Marker Score: 1547
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.24
    Marker Score: 1573

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Other Information

**Key Characteristics:** 1. **Olfactory Receptor:** OR4C12 is a type of olfactory receptor, specifically belonging to the olfactory receptor family 4 subfamily C. These receptors are responsible for detecting odorant molecules in the air, which triggers a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor:** OR4C12 belongs to the G protein-coupled receptor (GPCR) family, which is the largest family of receptors in the human genome. GPCRs are transmembrane receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and odorant molecules. 3. **Expression Pattern:** OR4C12 is expressed in various cell types, including parietal epithelial cells, podocytes, hematopoietic stem cells, and renal alpha-intercalated cells. This widespread expression suggests a diverse range of functions beyond olfaction. 4. **Signal Transduction:** OR4C12, like other GPCRs, activates a G protein upon binding to its ligand, triggering a signaling cascade that modulates downstream cellular responses. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR4C12 plays a critical role in detecting chemical stimuli involved in the perception of smell. The receptor's ability to bind to odorant molecules triggers a signaling cascade that ultimately leads to the perception of smell. 2. **Olfactory Signaling Pathway:** OR4C12 is part of the olfactory signaling pathway, which involves the coordinated activation of multiple olfactory receptors to detect complex odorant molecules. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR4C12, as a GPCR, is involved in the G protein-coupled receptor signaling pathway, which regulates a wide range of cellular responses, including ion transport, cell proliferation, and differentiation. 4. **Regulation of Immune Response:** Recent studies have suggested that OR4C12 may also play a role in regulating the immune response, particularly in the context of inflammation and immune cell activation. **Clinical Significance:** 1. **Olfactory Disorders:** Dysregulation of OR4C12 has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological Disorders:** OR4C12 has also been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. 3. **Infectious Diseases:** OR4C12 may play a role in the regulation of immune responses to infectious diseases, particularly in the context of respiratory infections. 4. **Cancer:** Recent studies have suggested that OR4C12 may also be involved in the regulation of cancer cell growth and proliferation, highlighting its potential as a therapeutic target. In conclusion, the OR4C12 gene is a critical component of the human olfactory system, with its functions extending beyond olfaction to regulate various physiological processes. Further research is needed to fully elucidate the mechanisms by which OR4C12 functions and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 2421638247

Symbol: OR4CC_HUMAN

Name: Olfactory receptor 4C12

UniProtKB Accession Codes:

Q96R67 B2RNF0 Q6IF49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 2 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 309
  • Mass: 34491
  • Checksum: 3C6AD9FA309457C9
  • Sequence:
    • MEKKKNVTEF ILIGLTQNPI MEKVTFVVFL VLYMITLSGN LLIVVTITTS QALSSPMYFF 
LTHLSLIDTV YSSSSAPKLI VDSFQEKKII SFNGCMAQAY AEHIFGATEI ILLTVMACDC 
YVAICKPLNY TTIMSHSLCI LLVAVAWVGG FLHATIQILF TVWLPFCGPN VIGHFMCDLY 
PLLKLVCIDT HTLGLFVAVN SGFICLLNFL ILVVSYVIIL RSLKNNSLEG RCKALSTCIS 
HIIVVVLFFV PCIFVYLRSV TTLPIDKAVA VFYTMVVPML NPVVYTLRNA EVKSAIRKLW 
RKKVTSDND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.