Details for: SPATA31D4

Gene ID: 389761

Symbol: SPATA31D4

Ensembl ID: ENSG00000189357

Description: SPATA31 subfamily D member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.0056
    Cell Significance Index: 0.0700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0053
    Cell Significance Index: 0.0400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0035
    Cell Significance Index: 0.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0032
    Cell Significance Index: -0.0300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0061
    Cell Significance Index: -0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0082
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0096
    Cell Significance Index: -0.0900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0101
    Cell Significance Index: -0.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0125
    Cell Significance Index: -0.1000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0135
    Cell Significance Index: -0.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0136
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0141
    Cell Significance Index: -0.1200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0162
    Cell Significance Index: -0.1100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0173
    Cell Significance Index: -0.1300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0184
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression**: SPATA31D4 is expressed in a diverse range of cell types, including neuronal receptor cells, smooth muscle myoblasts, pericytes, lymphoid lineage-restricted progenitor cells, goblet cells, kidney distal convoluted tubule epithelial cells, stromal cells, intestinal enteroendocrine cells, neoplastic cells, and abnormal cells. 2. **Cell differentiation**: SPATA31D4 plays a crucial role in regulating cell differentiation, particularly in the development of neuronal receptor cells and smooth muscle myoblasts. 3. **Membrane biology**: The gene is involved in maintaining membrane structure and function, with implications for cell signaling, migration, and adhesion. 4. **Spermatogenesis**: SPATA31D4 is specifically expressed in spermatogenic cells, suggesting a role in the regulation of spermatogenesis and male fertility. **Pathways and Functions:** 1. **Cell signaling**: SPATA31D4 modulates cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to regulate cellular behavior and homeostasis. 2. **Cell migration and adhesion**: The gene influences cell migration and adhesion, essential processes in tissue development, wound healing, and cancer metastasis. 3. **Spermatogenesis**: SPATA31D4 regulates the meiotic and mitotic processes of spermatogenesis, ensuring proper gametogenesis and male fertility. 4. **Cancer**: The gene has been implicated in cancer development and progression, particularly in neoplastic cells, where it may contribute to tumor growth, invasion, and metastasis. **Clinical Significance:** 1. **Male fertility**: Abnormalities in SPATA31D4 expression have been linked to male infertility, emphasizing the gene's role in spermatogenesis. 2. **Cancer diagnosis**: The gene's expression in neoplastic cells has implications for cancer diagnosis and prognosis, highlighting the potential for SPATA31D4 as a biomarker. 3. **Regenerative medicine**: Understanding the functions of SPATA31D4 may provide insights into regenerative medicine, particularly in the development of therapies for tissue repair and disease. 4. **Neurological disorders**: The gene's expression in neuronal receptor cells and smooth muscle myoblasts suggests a potential role in neurological disorders, such as Parkinson's disease and stroke. In conclusion, SPATA31D4 is a gene of great importance in cell differentiation, membrane biology, and spermatogenesis. Its diverse cellular expression patterns and pivotal roles in various biological processes make it an attractive target for further research and potential therapeutic applications.

Genular Protein ID: 1826296825

Symbol: S31D4_HUMAN

Name: Spermatogenesis-associated protein 31D4

UniProtKB Accession Codes:

Q6ZUB0 A0A0J9YX51

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 917
  • Mass: 102306
  • Checksum: DA2FB7A5B7814392
  • Sequence:
    • MENILCFLNS YTETGLSPDS HCLDIDLNFI CLSGLGLFIL YLFYMVLTLY SSPTEKNNDT 
QKHQGRARRK RKSVTFKDRK SLQKEAEEER KLHSFLKSFG PPVSCSPLGQ HHDTTLFRRL 
LCPDPVCRVC NRATADIQRL LSWESLKDAA PSVSPLASSA SGAESSFTLA STPSATTPED 
LILSSRPKPS PPPPLILSPD LITTLADLFS PSPLRDPLPP QPVSPLDSKF PIDHSPPQQL 
PFPLLPPHHI ERVEPSLQPE ASLSLNTIFS FGSTLCQDIS QAVNRTDSCA RHHGPPTPSA 
LPPEDCTVTQ SKSNLTVLKT FPEMLSLGGS GGSSTSAPTT KGIDHSCPAS SEFSWWQPHA 
KDSFSSNFVP SDFMEELLTL HSSEASLGGH SVANIIQPVN ISFLSHDIPA LLERQVKRRG 
DFLMWKENGK KPGSFPTQLR PNYQLNSSRN MLTSTAVKHD LAESFPFWAS KGKLEWQHIH 
QQPPYSKCFE DHLEQKYVQL FWGLPSLHSE SLHPTVFVQH GRSSMFVFFN GITNTSMSHE 
SPVLPPPQPL FLPSTQPLPL PQTLPRGQSL HLTQVKSLAQ PQSPFPALPP SPLFLIRVCG 
VCFHRPQNEA RSLMPSEINH LEWNVLQKVQ ESVWGLPSVV QKSQEDFCPP APNPVLVRKS 
FKVHVPISII PGDFPLSSEV RKKLEQHIRK RLIQRRWGLP RRIHESLSLL RPQNKISELS 
VSESIHGPLN ISLVEGQRCN VLKKSASSFP RSFHERSSNM LSMENVGNYQ GCSQETAPKN 
HLLHDPETSS DEDLRSNSER DLGTHMMHLS GNDSGVRLGQ KQLENALTVH LSKKFEEINE 
GRMPGTVHSS WHSVKQTICL PEKSHSQIKH RNLAALVSED HGVDTSQEMS FLSSNKQKML 
EAHIKSFHMK PILNLSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.