Details for: MIR296

Gene ID: 407022

Symbol: MIR296

Ensembl ID: ENSG00000284040

Description: microRNA 296

Associated with

  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of platelet-derived growth factor receptor signaling pathway
    (GO:0010641)
  • Positive regulation of vascular endothelial growth factor receptor signaling pathway
    (GO:0030949)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0005
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0001
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0033
    Cell Significance Index: -0.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0065
    Cell Significance Index: -0.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0072
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0073
    Cell Significance Index: -0.0600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0089
    Cell Significance Index: -0.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0105
    Cell Significance Index: -0.1100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0106
    Cell Significance Index: -0.1100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0113
    Cell Significance Index: -0.1100
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.0124
    Cell Significance Index: -0.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0142
    Cell Significance Index: -0.1100
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0142
    Cell Significance Index: -0.1400
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0226
    Cell Significance Index: -0.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **MicroRNA**: MIR296 is a small non-coding RNA, approximately 22 nucleotides in length, that plays a crucial role in regulating gene expression through post-transcriptional mechanisms. 2. **Cell-type specific expression**: MIR296 is significantly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage restricted progenitor cells, pericytes, cardiac endothelial cells, immature innate lymphoid cells, cardiac muscle myoblasts, fibroblasts of cardiac tissue, and Purkinje cells. 3. **Regulation of cell migration**: MIR296 is involved in the regulation of cell migration, a critical process in tissue development, wound healing, and cancer metastasis. 4. **Angiogenesis**: MIR296 plays a significant role in promoting angiogenesis, the formation of new blood vessels from pre-existing ones, which is essential for tissue development and growth. **Pathways and Functions:** 1. **Mirna-mediated post-transcriptional gene silencing**: MIR296 targets specific mRNAs for degradation or inhibition of translation, thereby regulating the expression of genes involved in cell migration, angiogenesis, and vascular development. 2. **mRNA 3'-utr binding**: MIR296 binds to the 3'-untranslated region (3'-UTR) of target mRNAs, leading to the degradation of these mRNAs or inhibition of their translation. 3. **mRNA base-pairing translational repressor activity**: MIR296 can also bind to mRNAs through base pairing, leading to the repression of translation. 4. **Positive regulation of cell migration**: MIR296 promotes cell migration by regulating the expression of genes involved in the cytoskeleton, adhesion molecules, and signaling pathways. 5. **Positive regulation of cell migration involved in sprouting angiogenesis**: MIR296 promotes angiogenesis by regulating the expression of genes involved in the sprouting of new blood vessels. 6. **Positive regulation of platelet-derived growth factor receptor signaling pathway**: MIR296 regulates the expression of genes involved in the PDGFR signaling pathway, which is critical for cell migration and angiogenesis. 7. **Positive regulation of vascular endothelial growth factor receptor signaling pathway**: MIR296 regulates the expression of genes involved in the VEGFR signaling pathway, which is essential for angiogenesis and vascular development. **Clinical Significance:** 1. **Cancer**: MIR296 has been implicated in cancer development and progression, where it regulates the expression of genes involved in cell migration, angiogenesis, and metastasis. 2. **Cardiovascular diseases**: MIR296 plays a critical role in vascular development and maintenance, making it a potential target for the treatment of cardiovascular diseases, such as atherosclerosis and hypertension. 3. **Neurological disorders**: MIR296 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal function and survival. 4. **Regenerative medicine**: MIR296 has potential applications in regenerative medicine, where it can be used to promote tissue repair and regeneration. In conclusion, microRNA 296 (MIR296) is a critical regulator of cell migration, angiogenesis, and vascular development, playing a significant role in various diseases, including cancer, cardiovascular diseases, and neurological disorders. Further research is needed to fully understand the mechanisms of MIR296 and its potential applications in regenerative medicine and disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.