Details for: SNORA63

Gene ID: 6043

Symbol: SNORA63

Ensembl ID: ENSG00000200320

Description: small nucleolar RNA, H/ACA box 63

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0058
    Cell Significance Index: 0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.0081
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0091
    Cell Significance Index: -0.1100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0091
    Cell Significance Index: -0.0900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0107
    Cell Significance Index: -0.1300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0108
    Cell Significance Index: -0.1000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0118
    Cell Significance Index: -0.1300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0120
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0136
    Cell Significance Index: -0.1200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0144
    Cell Significance Index: -0.1000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0148
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0153
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0269
    Cell Significance Index: -0.1300
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.0630
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA63 is a 63-base pair snoRNA that belongs to the H/ACA box family, characterized by its unique structure and functionality. As a small nucleolar RNA, it is involved in the processing of ribosomal RNA (rRNA) and other non-coding RNAs. The H/ACA box motif is a critical feature of SNORA63, allowing it to interact with the Box H/ACA RNP complex, a multifunctional assembly responsible for guiding the processing of specific rRNA species. This complex is composed of various proteins, including H/ACA proteins, which are essential for the formation of the Box H/ACA RNP complex. **Pathways and Functions:** SNORA63's involvement in RNA processing and the assembly of the Box H/ACA RNP complex highlights its role in regulating gene expression and maintaining cellular homeostasis. The Box H/ACA RNP complex is involved in the processing of specific rRNA species, such as 28S rRNA, which is essential for ribosome biogenesis and function. SNORA63's interaction with this complex enables the efficient processing of these rRNA species, ensuring proper ribosome assembly and function. Furthermore, SNORA63's expression in various cell types suggests its involvement in regulating cellular processes, such as cell differentiation, proliferation, and survival. **Clinical Significance:** The clinical significance of SNORA63 is an area of ongoing research. Given its widespread expression in various cell types, SNORA63 may play a role in the development and progression of various diseases, including cancer, cardiovascular disease, and immune-related disorders. For instance, dysregulation of SNORA63 expression has been implicated in the pathogenesis of certain cancers, such as leukemia and lymphoma. Additionally, SNORA63's involvement in RNA processing and the assembly of the Box H/ACA RNP complex may provide insights into the molecular mechanisms underlying various diseases, including neurodegenerative disorders and autoimmune diseases. In conclusion, SNORA63 is a small nucleolar RNA that plays a crucial role in regulating RNA processing and maintaining cellular homeostasis. Its widespread expression in various cell types and involvement in the assembly of the Box H/ACA RNP complex highlight its significance in cellular processes. Further research is necessary to fully elucidate the clinical significance of SNORA63 and its potential role in various diseases. As an expert immunologist, I am eager to continue exploring the intricacies of SNORA63 and its implications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.