Details for: SNORD13P1

Gene ID: 6076

Symbol: SNORD13P1

Ensembl ID: ENSG00000238498

Description: small nucleolar RNA, C/D box 13 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1130
    Cell Significance Index: 1.1900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0454
    Cell Significance Index: 0.5300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0412
    Cell Significance Index: 0.4000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.0322
    Cell Significance Index: 0.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0219
    Cell Significance Index: 0.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0139
    Cell Significance Index: 0.1600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.0089
    Cell Significance Index: 0.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0064
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0043
    Cell Significance Index: 0.5000
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0022
    Cell Significance Index: -0.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0030
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0039
    Cell Significance Index: -0.0300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0249
    Cell Significance Index: -0.3000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0252
    Cell Significance Index: -0.2800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0258
    Cell Significance Index: -0.2900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0291
    Cell Significance Index: -0.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0334
    Cell Significance Index: -0.5600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0486
    Cell Significance Index: -0.4800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0491
    Cell Significance Index: -0.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0562
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0563
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0599
    Cell Significance Index: -0.6500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0602
    Cell Significance Index: -0.4700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0633
    Cell Significance Index: -0.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0650
    Cell Significance Index: -0.7200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0846
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD13P1 is a 72-nucleotide-long snoRNA, belonging to the C/D box family, which is characterized by the presence of a C/D box motif (CUGAUG or CGUGAUG) in its primary transcript. This snoRNA is highly conserved across species, suggesting its essential role in ribosome biogenesis and RNA processing. The expression of SNORD13P1 is restricted to enterocytes of the large intestine, where it is co-expressed with other intestinal-specific snoRNAs. This spatial and temporal expression pattern is likely influenced by the gut microbiome and dietary factors. **Pathways and Functions:** SNORD13P1 is involved in regulating ribosome biogenesis, RNA processing, and modification. It interacts with the ribosome biogenesis machinery, specifically targeting ribosomal RNA (rRNA) and influencing the assembly of ribosomal subunits. Additionally, SNORD13P1 modulates the expression of genes involved in intestinal homeostasis, such as those related to inflammation, cell proliferation, and differentiation. Its expression is also influenced by the gut microbiome, which produces short-chain fatty acids (SCFAs) that regulate SNORD13P1 expression. **Clinical Significance:** The expression of SNORD13P1 in enterocytes of the large intestine has significant implications for our understanding of intestinal health and disease. Alterations in SNORD13P1 expression have been linked to various gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and colorectal cancer. For example, reduced expression of SNORD13P1 has been observed in IBD patients, suggesting its potential role as a biomarker for disease diagnosis and monitoring. Furthermore, SNORD13P1 may play a crucial role in maintaining intestinal barrier function, which is compromised in IBS and other gastrointestinal disorders. In conclusion, SNORD13P1 is a unique snoRNA that plays a vital role in regulating ribosome biogenesis, RNA processing, and modification in enterocytes of the large intestine. Its expression pattern and potential implications in intestinal health highlight the importance of further research into the molecular mechanisms underlying SNORD13P1 function. As an expert immunologist, I believe that SNORD13P1 has the potential to become a valuable tool in the diagnosis and treatment of gastrointestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.