Details for: TRBV21OR9 2

Gene ID: 6959

Symbol: TRBV21OR9 2

Ensembl ID: ENSG00000183938

Description: T cell receptor beta variable 21/OR9-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0156
    Cell Significance Index: 0.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0132
    Cell Significance Index: 0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0069
    Cell Significance Index: 0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0068
    Cell Significance Index: 0.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0037
    Cell Significance Index: 0.0900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0020
    Cell Significance Index: 0.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0024
    Cell Significance Index: -0.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0036
    Cell Significance Index: -0.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0044
    Cell Significance Index: -0.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0095
    Cell Significance Index: -0.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0111
    Cell Significance Index: -0.1100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0178
    Cell Significance Index: -0.1200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0179
    Cell Significance Index: -0.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0190
    Cell Significance Index: -0.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0234
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: TRBV21OR9 2 is a pseudogene, meaning it lacks a functional open reading frame (ORF) and does not produce a protein that can be translated into a functional protein. 2. **Widespread expression**: This gene is expressed in various cell types, including hematopoietic stem cells, erythrocytes, mast cells, goblet cells, and neoplastic cells. 3. **Immunological significance**: Despite its pseudogene status, TRBV21OR9 2 is significantly expressed in cells that play crucial roles in the immune system, such as T cells and mast cells. **Pathways and Functions:** 1. **T cell receptor signaling**: Although TRBV21OR9 2 lacks a functional ORF, it is co-expressed with TRBV21-2, a functional T cell receptor beta chain. This co-expression suggests that TRBV21OR9 2 may play a regulatory role in T cell receptor signaling, modulating the affinity and specificity of T cell receptor interactions with antigens. 2. **Gene regulation**: TRBV21OR9 2 may function as a long non-coding RNA (lncRNA), regulating gene expression through various mechanisms, including epigenetic modifications and transcriptional interference. 3. **Cellular differentiation**: The expression of TRBV21OR9 2 in goblet cells and intestinal crypt stem cells suggests that it may play a role in cellular differentiation and development. **Clinical Significance:** 1. **Cancer research**: The expression of TRBV21OR9 2 in neoplastic cells suggests that it may be involved in the development and progression of various cancers, including leukemia and lymphoma. 2. **Immunological disorders**: The expression of TRBV21OR9 2 in mast cells and goblet cells suggests that it may be involved in the pathogenesis of immunological disorders, such as allergic reactions and inflammatory diseases. 3. **Gene therapy**: Further research is needed to understand the functional significance of TRBV21OR9 2, which may lead to the development of novel gene therapies targeting this pseudogene. In conclusion, the TRBV21OR9 2 gene is a complex and enigmatic pseudogene that warrants further investigation. Its widespread expression in various cell types and potential regulatory role in T cell receptor signaling and gene regulation make it an attractive target for future research in immunology and cancer biology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.