Details for: CDRT7

Gene ID: 94150

Symbol: CDRT7

Ensembl ID: ENSG00000259944

Description: CMT1A duplicated region transcript 7

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.1817
    Cell Significance Index: 2.3300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0862
    Cell Significance Index: 0.8700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0818
    Cell Significance Index: 1.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0617
    Cell Significance Index: 0.9100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0430
    Cell Significance Index: 0.5100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0284
    Cell Significance Index: 0.2900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0237
    Cell Significance Index: 0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0161
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0167
    Cell Significance Index: -0.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0214
    Cell Significance Index: -0.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0238
    Cell Significance Index: -0.2800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0249
    Cell Significance Index: -0.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0253
    Cell Significance Index: -0.2900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0256
    Cell Significance Index: -0.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0272
    Cell Significance Index: -0.2300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0283
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0288
    Cell Significance Index: -0.2800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0289
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0300
    Cell Significance Index: -0.3600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0302
    Cell Significance Index: -0.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0348
    Cell Significance Index: -0.3500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0350
    Cell Significance Index: -0.4100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0353
    Cell Significance Index: -0.3000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0375
    Cell Significance Index: -0.4700
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0392
    Cell Significance Index: -0.2800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0397
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0429
    Cell Significance Index: -0.3500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0441
    Cell Significance Index: -0.4700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0445
    Cell Significance Index: -0.4700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0476
    Cell Significance Index: -0.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0494
    Cell Significance Index: -0.5800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0524
    Cell Significance Index: -0.4600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0541
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0581
    Cell Significance Index: -0.6300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0813
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDRT7 is a non-coding gene, meaning it does not encode a protein sequence. Instead, it is a transcript that arises from the duplication of the CMT1A gene, a gene associated with Charcot-Marie-Tooth disease type 1A. The CDRT7 transcript is primarily expressed in cells of the immune system, including T cells, mast cells, plasma cells, and pericytes, as well as in non-immune cells such as smooth muscle myoblasts and endothelial cells. Its expression is also noted in certain types of cancer, including intestinal cancer. **Pathways and Functions:** Despite its non-coding nature, CDRT7 has been implicated in various signaling pathways, including the Notch signaling pathway, which plays a critical role in cell differentiation, proliferation, and survival. The CDRT7 transcript is thought to modulate the activity of this pathway, influencing the development and function of immune cells. Furthermore, CDRT7 has been shown to interact with other non-coding RNAs, such as microRNAs and long non-coding RNAs, to regulate gene expression and cellular behavior. **Clinical Significance:** The clinical significance of CDRT7 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. For instance, CDRT7 has been identified as a biomarker for certain types of cancer, including intestinal cancer, where its expression is often upregulated. Additionally, CDRT7 has been implicated in autoimmune diseases, such as multiple sclerosis, where its dysregulation may contribute to the development of disease-specific immune responses. In the context of immunology, CDRT7 may play a role in modulating immune responses, particularly in the development and function of T cells and other immune cells. Further research is needed to fully elucidate the mechanisms by which CDRT7 influences immune function and to explore its potential as a therapeutic target for immunological disorders. **Conclusion:** In conclusion, CDRT7 is a complex and enigmatic gene that has shed new light on the intricacies of immune system regulation. While its non-coding nature may seem limiting, CDRT7's ability to modulate signaling pathways and interact with other non-coding RNAs has far-reaching implications for our understanding of immune function and disease. As research continues to unravel the mysteries of CDRT7, it is likely that this gene will emerge as a crucial player in the development of novel therapeutic strategies for a range of immunological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.