Details for: LOC100129203

Gene ID: 100129203

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC100129203

Ensembl ID: ENSG00000245552

Description: uncharacterized LOC100129203

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • inhibitory interneuron CL0000498
    CSI 7.13
    rCSI 16.46%
    PRS 86.75
  • adipocyte CL0000136
    CSI 6.62
    rCSI 8.5%
    PRS 87.01
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.84
    rCSI 12.27%
    PRS 89.62
  • retinal bipolar neuron CL0000748
    CSI 4.7
    rCSI 8.8%
    PRS 87.23
  • melanocyte CL0000148
    CSI 4.66
    rCSI 3.45%
    PRS 91.31
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.07
    rCSI 2.86%
    PRS 97.57
  • hepatic stellate cell CL0000632
    CSI 4.01
    rCSI 15.03%
    PRS 90.77
  • blood vessel endothelial cell CL0000071
    CSI 3.96
    rCSI 8.22%
    PRS 92.32
  • rod bipolar cell CL0000751
    CSI 3.85
    rCSI 6.91%
    PRS 89.8
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.43
    rCSI 3.96%
    PRS 87.37
  • vascular leptomeningeal cell CL4023051
    CSI 3.42
    rCSI 5.99%
    PRS 91.37
  • radial glial cell CL0000681
    CSI 3.37
    rCSI 4.68%
    PRS 92.24
  • Mueller cell CL0000636
    CSI 3.18
    rCSI 7.26%
    PRS 88.57
  • interneuron CL0000099
    CSI 3.15
    rCSI 6.32%
    PRS 89.21
  • mesothelial cell CL0000077
    CSI 3.08
    rCSI 12.06%
    PRS 81
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.97
    rCSI 3.82%
    PRS 84.92
  • chondrocyte CL0000138
    CSI 2.95
    rCSI 4.69%
    PRS 90.22
  • neural crest cell CL0011012
    CSI 2.88
    rCSI 2.28%
    PRS 88.48
  • diffuse bipolar 2 cell CL4033028
    CSI 2.81
    rCSI 21.75%
    PRS 87.25
  • glioblast CL0000030
    CSI 2.71
    rCSI 4.33%
    PRS 87.55
  • diffuse bipolar 3a cell CL4033029
    CSI 2.68
    rCSI 18.27%
    PRS 86.68
  • erythrocyte CL0000232
    CSI 2.55
    rCSI 5.78%
    PRS 91.66
  • conjunctival epithelial cell CL1000432
    CSI 2.48
    rCSI 3.79%
    PRS 92.75
  • retinal ganglion cell CL0000740
    CSI 2.41
    rCSI 5.32%
    PRS 85.55
  • cardiac neuron CL0010022
    CSI 2.29
    rCSI 7.33%
    PRS 92.77
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.26
    rCSI 2.81%
    PRS 81.87
  • Bergmann glial cell CL0000644
    CSI 2.23
    rCSI 3.05%
    PRS 87.92
  • Schwann cell CL0002573
    CSI 2.19
    rCSI 6.22%
    PRS 90.78
  • lung secretory cell CL1000272
    CSI 2.06
    rCSI 5.09%
    PRS 94.97
  • fibroblast of cardiac tissue CL0002548
    CSI 1.82
    rCSI 8.71%
    PRS 94.53
  • diffuse bipolar 1 cell CL4033027
    CSI 1.77
    rCSI 13.3%
    PRS 84.21
  • ON midget ganglion cell CL4033046
    CSI 1.66
    rCSI 33.86%
    PRS 86.82
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.57
    rCSI 37.88%
    PRS 81.77
  • diffuse bipolar 6 cell CL4033032
    CSI 1.54
    rCSI 8.09%
    PRS 84.98
  • OFF midget ganglion cell CL4033047
    CSI 1.35
    rCSI 27.54%
    PRS 87.34
  • direct pathway medium spiny neuron CL4023026
    CSI 1.34
    rCSI 32.04%
    PRS 81.81
  • diffuse bipolar 3b cell CL4033030
    CSI 1.23
    rCSI 8.19%
    PRS 88.51
  • OFFx cell CL4033036
    CSI 1.18
    rCSI 5.56%
    PRS 85
  • GABAergic amacrine cell CL4030027
    CSI 1.11
    rCSI 3.8%
    PRS 83.33
  • blood vessel smooth muscle cell CL0019018
    CSI 0.7
    rCSI 5.71%
    PRS 92.32
  • ON parasol ganglion cell CL4033052
    CSI 0.59
    rCSI 8.36%
    PRS 87.52

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC100129203](/details-gene/100129203) is an uncharacterized non-coding RNA (ncRNA) located on human chromosome 11q21. Despite its unknown function, expression data reveals a distinct and significant profile across a surprisingly diverse range of cell types. **Overall**, it shows the highest significance in neuronal cells, particularly [inhibitory interneurons](/details-cell/CL0000498), suggesting a potential role in the regulation of the central nervous system. However, its strong expression in metabolically active cells such as [adipocytes](/details-cell/CL0000136) and specialized epithelial cells like [kidney connecting tubule epithelial cells](/details-cell/CL1000768) indicates a pleiotropic function that may involve fundamental regulatory processes common to multiple distinct cellular lineages. ## Cellular Roles and Expression Landscape The expression landscape of [LOC100129203](/details-gene/100129203) is notably broad, yet specific to certain cell types, suggesting a multifaceted role in cellular identity and function. A predominant theme is its significance within the nervous system. The gene exhibits its highest cell significance index (CSI) in [inhibitory interneurons](/details-cell/CL0000498) (CSI: 7.13), implying a specialized function in neuronal regulation and synaptic communication. This is further substantiated by its notable expression in other neural-related cells, including [retinal bipolar neurons](/details-cell/CL0000748), [neuroblasts](/details-cell/CL0000338), and glial cells such as [radial glial cells](/details-cell/CL0000681) and [Mueller cells](/details-cell/CL0000636). This pattern suggests that [LOC100129203](/details-gene/100129203) may be involved in neurodevelopment and the maintenance of mature neuronal circuits. Beyond the nervous system, [LOC100129203](/details-gene/100129203) shows a remarkably high CSI in [adipocytes](/details-cell/CL0000136) (CSI: 6.62), pointing towards a potential, uncharacterized role in lipid metabolism, energy storage, or adipocyte differentiation. The gene's diverse expression profile is further highlighted by its significance in other specialized cells, including [kidney connecting tubule epithelial cells](/details-cell/CL1000768), [melanocytes](/details-cell/CL0000148) of neural crest origin, [hepatic stellate cells](/details-cell/CL0000632), and even immune cells like [naive thymus-derived CD8-positive, alpha-beta T cells](/details-cell/CL0000900). This wide-ranging expression pattern suggests it may regulate a fundamental cellular process that is leveraged differently across various tissues. ## Pathways and Molecular Function As an uncharacterized non-coding RNA, the precise molecular function and associated pathways of [LOC100129203](/details-gene/100129203) are currently unknown. ncRNAs typically exert their influence by regulating gene expression at transcriptional or post-transcriptional levels, acting as scaffolds for protein complexes, or modifying chromatin structure. Given its pleiotropic expression profile, it is plausible that [LOC100129203](/details-gene/100129203) interacts with widely expressed proteins or coregulatory complexes to fine-tune cell-type-specific transcriptional programs. For instance, in [inhibitory interneurons](/details-cell/CL0000498), it might modulate genes critical for GABAergic signaling or synaptic plasticity. In contrast, within [adipocytes](/details-cell/CL0000136), it could influence pathways related to lipid droplet formation or insulin sensitivity. Elucidating its binding partners and downstream targets will be essential to define its molecular role. ## Research Directions The uncharacterized nature of [LOC100129203](/details-gene/100129203), combined with its intriguing expression profile, presents several avenues for future research. **Proposed Testable Hypotheses:** 1. Given its high significance in [inhibitory interneurons](/details-cell/CL0000498) and other neuronal precursors, [LOC100129203](/details-gene/100129203) likely functions as a key regulator of neuronal differentiation and synaptic function. Its knockdown would be expected to impair the maturation or inhibitory capacity of these neurons, potentially leading to an excitatory/inhibitory imbalance. 2. The high expression of [LOC100129203](/details-gene/100129203) in [adipocytes](/details-cell/CL0000136) suggests it plays a role in metabolic regulation. It may be a critical factor in adipogenesis or the control of lipid metabolism, and its dysregulation could be a contributing factor in metabolic diseases like obesity or insulin resistance. **Suggested Key Experiments:** To test the hypothesis that [LOC100129203](/details-gene/100129203) is critical for interneuron function, a loss-of-function study could be performed. Human pluripotent stem cells could be differentiated into interneuron progenitors, followed by treatment with specific antisense oligonucleotides (ASOs) or CRISPR interference (CRISPRi) to knockdown [LOC100129203](/details-gene/100129203) expression. The effects on neuronal differentiation and identity could be quantified using single-cell RNA sequencing and immunofluorescence for key markers (e.g., GAD67, Parvalbumin). Functional consequences on neuronal activity and synaptic transmission could then be assessed in mature cultures via multi-electrode array (MEA) or patch-clamp electrophysiology. **Therapeutic Potential:** The therapeutic potential of [LOC100129203](/details-gene/100129203) is currently speculative but intriguing. If it is confirmed as a crucial regulator of interneuron function, it could represent a novel target for RNA-based therapies (e.g., ASOs) aimed at correcting inhibitory signaling deficits in neurological or psychiatric conditions such as epilepsy or schizophrenia. Similarly, if its role in [adipocytes](/details-cell/CL0000136) is linked to metabolic disease, modulating its activity could offer a new therapeutic strategy. Before its potential can be realized, foundational research is required to uncover its molecular mechanism and its role in disease pathology.