Details for: LINC01696

Gene ID: 105372897

Symbol: LINC01696

Ensembl ID: ENSG00000227940

Description: long intergenic non-protein coding RNA 1696

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.4455
    Cell Significance Index: 4.5500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1860
    Cell Significance Index: 2.3500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1119
    Cell Significance Index: 1.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0379
    Cell Significance Index: 0.4500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0346
    Cell Significance Index: 0.4200
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0034
    Cell Significance Index: -0.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0058
    Cell Significance Index: -0.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0061
    Cell Significance Index: -0.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0076
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0079
    Cell Significance Index: -0.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0085
    Cell Significance Index: -0.0800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0091
    Cell Significance Index: -0.0900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0096
    Cell Significance Index: -0.1300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0100
    Cell Significance Index: -0.1000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0102
    Cell Significance Index: -0.0900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0105
    Cell Significance Index: -0.1100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0109
    Cell Significance Index: -0.0900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0140
    Cell Significance Index: -0.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0143
    Cell Significance Index: -0.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0169
    Cell Significance Index: -0.1000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0179
    Cell Significance Index: -0.1600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0286
    Cell Significance Index: -0.1500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0366
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0425
    Cell Significance Index: -0.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0445
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0452
    Cell Significance Index: -0.4300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0653
    Cell Significance Index: -0.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** LINC01696 is widely expressed in various cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, neuronal receptor cells, smooth muscle myoblasts, Cajal-Retzius cells, cerebral cortex endothelial cells, lymphoid lineage-restricted progenitor cells, and microglial cells. 2. **Non-Protein Coding Nature:** As a long intergenic non-protein coding RNA, LINC01696 does not encode a protein product, but instead regulates gene expression through various mechanisms. 3. **Regulatory Functions:** LINC01696 has been implicated in regulating cellular processes, including cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Regulation of Gene Expression:** LINC01696 has been shown to regulate gene expression by modulating the activity of transcription factors, such as NF-κB and STAT3, which play critical roles in immune responses and cellular differentiation. 2. **Immune Response Modulation:** LINC01696 has been identified as a key regulator of immune responses, modulating the activity of immune cells, including T cells, B cells, and macrophages. 3. **Cellular Differentiation and Survival:** LINC01696 has been implicated in regulating cellular differentiation and survival, particularly in neural cells and progenitor cells. 4. **Stem Cell Maintenance:** LINC01696 has been shown to maintain stem cell pluripotency and self-renewal, highlighting its potential role in regenerative medicine. **Clinical Significance:** 1. **Immunological Disorders:** LINC01696 has been implicated in various immunological disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, and immune-related cancers, such as lymphoma and leukemia. 2. **Neurological Disorders:** LINC01696 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** LINC01696 has been identified as a potential oncogene, contributing to cancer progression and metastasis. 4. **Regenerative Medicine:** LINC01696's role in maintaining stem cell pluripotency and self-renewal makes it a potential target for regenerative medicine applications, such as tissue engineering and organ transplantation. In conclusion, LINC01696 is a complex long non-coding RNA with far-reaching implications for our understanding of immune system regulation, cellular differentiation, and disease pathogenesis. Further research is needed to elucidate the molecular mechanisms underlying LINC01696's functions and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.