Details for: TRAJ35

Gene ID: 28720

Symbol: TRAJ35

Ensembl ID: ENSG00000211854

Description: T cell receptor alpha joining 35 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 6.4029
    Cell Significance Index: 125.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1107
    Cell Significance Index: 26.9000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0038
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0078
    Cell Significance Index: -0.1000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0094
    Cell Significance Index: -0.1200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0117
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0125
    Cell Significance Index: -0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0182
    Cell Significance Index: -0.1700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0369
    Cell Significance Index: -0.8100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1180
    Cell Significance Index: -0.9600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1364
    Cell Significance Index: -1.7000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1478
    Cell Significance Index: -1.9400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1814
    Cell Significance Index: -2.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2709
    Cell Significance Index: -4.3900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2719
    Cell Significance Index: -3.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2727
    Cell Significance Index: -3.0200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2987
    Cell Significance Index: -3.0100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3514
    Cell Significance Index: -4.5900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3678
    Cell Significance Index: -3.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3693
    Cell Significance Index: -3.1900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.4684
    Cell Significance Index: -3.8400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6451
    Cell Significance Index: -3.5200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -1.3096
    Cell Significance Index: -3.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional T cell receptor alpha joining**: TRAJ35 lacks the typical functional T cell receptor (TCR) alpha joining domain, which is essential for T cell receptor (TCR) assembly and activation. 2. **Widespread expression**: TRAJ35 is expressed in a diverse range of immune cells, including leukocytes, innate lymphoid cells, B cells, and mature T cells. 3. **Alpha-beta T cell-specific expression**: TRAJ35 is predominantly expressed in alpha-beta T cells, which are a crucial component of the adaptive immune system. 4. **Cellular specificity**: TRAJ35 is also expressed in retinal rod cells, which highlights its non-specific expression in non-immune cells. **Pathways and Functions:** While TRAJ35 is non-functional, its expression may still contribute to the regulation of immune responses through various mechanisms: 1. **Immunoregulation**: TRAJ35 may modulate immune responses by influencing the expression of other T cell surface molecules, such as TCRs, co-receptors, or cytokine receptors. 2. **Immune cell development**: TRAJ35 may play a role in the development and maturation of immune cells, particularly alpha-beta T cells, by regulating the expression of other T cell surface molecules. 3. **Cell-cell interactions**: TRAJ35 may participate in cell-cell interactions, such as T cell-T cell interactions, by modulating the expression of adhesion molecules or other surface proteins. **Clinical Significance:** The clinical significance of TRAJ35 is an area of ongoing research, and its implications are multifaceted: 1. **Immune system dysregulation**: TRAJ35 may contribute to immune system dysregulation, which can lead to autoimmune diseases or impaired immune responses. 2. **Cancer association**: The expression of TRAJ35 in non-immune cells, such as retinal rod cells, may be associated with cancer, as these cells can evade immune surveillance. 3. **Gene therapy**: TRAJ35 may serve as a potential target for gene therapy, aimed at modulating immune responses in diseases characterized by immune system dysregulation. In conclusion, the TRAJ35 gene is a non-functional variant of the T cell receptor alpha joining, which exhibits widespread expression across various immune cells. While its non-functional status limits its direct involvement in T cell receptor assembly and activation, its expression may still contribute to the regulation of immune responses and cellular development. Further research is necessary to elucidate the clinical significance of TRAJ35 and its potential applications in immunotherapy and gene therapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.