Details for: MAGEB5

Gene ID: 347541

Symbol: MAGEB5

Ensembl ID: ENSG00000188408

Description: MAGE family member B5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1035
    Cell Significance Index: 1.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0522
    Cell Significance Index: 0.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0501
    Cell Significance Index: 0.3000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0241
    Cell Significance Index: 0.2900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0043
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0121
    Cell Significance Index: -2.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0165
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0209
    Cell Significance Index: -2.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0230
    Cell Significance Index: -0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0284
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0305
    Cell Significance Index: -3.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0547
    Cell Significance Index: -0.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0787
    Cell Significance Index: -1.0800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0958
    Cell Significance Index: -1.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0994
    Cell Significance Index: -1.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1059
    Cell Significance Index: -1.4600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1275
    Cell Significance Index: -1.6200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1335
    Cell Significance Index: -1.7600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1349
    Cell Significance Index: -1.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1365
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1375
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1375
    Cell Significance Index: -1.6900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1401
    Cell Significance Index: -1.4300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1436
    Cell Significance Index: -1.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1465
    Cell Significance Index: -1.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1475
    Cell Significance Index: -1.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1482
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1576
    Cell Significance Index: -1.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1618
    Cell Significance Index: -1.7400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1636
    Cell Significance Index: -1.3000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1698
    Cell Significance Index: -1.7900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1797
    Cell Significance Index: -1.2900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1813
    Cell Significance Index: -1.5900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2025
    Cell Significance Index: -1.7700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.2047
    Cell Significance Index: -1.5600
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: -0.2251
    Cell Significance Index: -1.5800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2283
    Cell Significance Index: -1.7000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2808
    Cell Significance Index: -3.3400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2892
    Cell Significance Index: -2.1000
  • Cell Name: serous cell of epithelium of bronchus (CL1000331)
    Fold Change: -0.3312
    Cell Significance Index: -1.3800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3437
    Cell Significance Index: -1.8400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3688
    Cell Significance Index: -3.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4042
    Cell Significance Index: -6.9700
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.5534
    Cell Significance Index: -4.6100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.5588
    Cell Significance Index: -6.0500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.6459
    Cell Significance Index: -4.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEB5 is a member of the MAGE family, which consists of 12 genes that are primarily expressed in melanoma cells, but are also found in other types of cancers. MAGEB5 is specifically expressed in various cell types, including kidney capillary endothelial cells, renal beta-intercalated cells, mononuclear cells, neuronal receptor cells, and smooth muscle myoblasts. This widespread expression suggests that MAGEB5 plays a role in regulating immune responses in multiple cell types. **Pathways and Functions:** MAGEB5 is involved in the regulation of transcription by RNA polymerase II, a crucial process for gene expression. Specifically, MAGEB5 acts as a negative regulator of transcription, which means that it inhibits the expression of other genes. This function is mediated by the MAGEB5 protein, which is a member of the MAGE family of proteins. These proteins are characterized by their ability to bind to specific DNA sequences and regulate gene expression. The MAGEB5 protein is also involved in the regulation of cellular processes, including cell proliferation, differentiation, and survival. In the context of cancer, MAGEB5 has been shown to be overexpressed in various tumor types, including melanoma, breast cancer, and lung cancer. This overexpression is thought to contribute to tumor progression and immune evasion. **Clinical Significance:** The clinical significance of MAGEB5 lies in its potential as a tumor-associated antigen (TAA) for cancer immunotherapy. TAAs are proteins or peptides that are expressed on the surface of cancer cells and can be recognized by the immune system. MAGEB5 is a promising TAA candidate due to its widespread expression in various cancers and its ability to regulate immune responses. Cancer immunotherapy using MAGEB5 as a TAA has shown promising results in preclinical studies. By targeting MAGEB5 with specific antibodies or T-cell therapies, it is possible to stimulate an immune response against cancer cells expressing this antigen. This approach has the potential to improve treatment outcomes for patients with various types of cancer. In conclusion, MAGEB5 is a member of the MAGE family that plays a crucial role in regulating immune responses and gene expression. Its clinical significance lies in its potential as a tumor-associated antigen for cancer immunotherapy. Further research is needed to fully understand the mechanisms of MAGEB5 and its role in cancer, but the existing evidence suggests that this gene has significant implications for cancer treatment.

Genular Protein ID: 76647650

Symbol: MAGB5_HUMAN

Name: Melanoma-associated antigen B5

UniProtKB Accession Codes:

Q9BZ81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 10861452

Title: MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.

PubMed ID: 10861452

DOI: 10.1002/1097-0215(20000701)87:1<55::aid-ijc8>3.3.co;2-a

Sequence Information:

  • Length: 275
  • Mass: 31906
  • Checksum: 57EDE75D76D07004
  • Sequence:
    • MTSAGVFNAG SDERANSRDE EYPCSSEVSP STESSCSNFI NIKVGLLEQF LLYKFKMKQR 
ILKEDMLKIV NPRYQNQFAE IHRRASEHIE VVFAVDLKEV NPTCHLYDLV SKLKLPNNGR 
IHVGKVLPKT GLLMTFLVVI FLKGNCANKE DTWKFLDMMQ IYDGKKYYIY GEPRKLITQD 
FVRLTYLEYH QVPCSYPAHY QFLWGPRAYT ETSKMKVLEY LAKVNDIAPG AFSSQYEEAL 
QDEEESPSQR CSRNWHYCSG QDCLRAKFSS FSQPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.