HCG23 | ENSG00000225914 | NCBI 414764

Details for: HCG23

Gene ID: 414764

Gene Type: ncRNA (Non-coding RNA) - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: HCG23

Ensembl ID: ENSG00000225914

Description: HLA complex group 23

Cell Significance Landscape

Display Count:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

VIP GABAergic cortical interneuron CL4023016

CSI 17.54

rCSI 20.95%

PRS 91.49
interstitial cell of Cajal CL0002088

CSI 10.08

rCSI 12.84%

PRS 98.52
sst GABAergic cortical interneuron CL4023017

CSI 9.67

rCSI 12.47%

PRS 92.05
sncg GABAergic cortical interneuron CL4023015

CSI 8.02

rCSI 12.9%

PRS 91.86
mesothelial cell CL0000077

CSI 8.01

rCSI 31.33%

PRS 89.25
amacrine cell CL0000561

CSI 7.35

rCSI 21.29%

PRS 92.75
glioblast CL0000030

CSI 7.17

rCSI 11.44%

PRS 93.18
GABAergic amacrine cell CL4030027

CSI 6.96

rCSI 23.85%

PRS 89.59
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 6.65

rCSI 11.75%

PRS 91.29
Mueller cell CL0000636

CSI 5.86

rCSI 13.37%

PRS 94.1
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 5.35

rCSI 6.18%

PRS 93.05
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 5.01

rCSI 12.17%

PRS 89.94
Schwann cell CL0002573

CSI 4.86

rCSI 13.82%

PRS 95.11
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.6

rCSI 17.38%

PRS 91.37
neural crest cell CL0011012

CSI 4.01

rCSI 3.17%

PRS 94.74
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 3.61

rCSI 8.63%

PRS 91.22
cardiac neuron CL0010022

CSI 3.41

rCSI 10.92%

PRS 96.42
Bergmann glial cell CL0000644

CSI 3.34

rCSI 4.56%

PRS 93.25
endocardial cell CL0002350

CSI 3.11

rCSI 14.91%

PRS 95.24
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.98

rCSI 5%

PRS 91.62
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 2.86

rCSI 10.29%

PRS 90.16
parietal epithelial cell CL1000452

CSI 2.34

rCSI 6.25%

PRS 95
basal cell of epidermis CL0002187

CSI 2.12

rCSI 3.75%

PRS 76.91
kidney connecting tubule epithelial cell CL1000768

CSI 2.1

rCSI 5.33%

PRS 94.54
renal principal cell CL0005009

CSI 2.09

rCSI 5.43%

PRS 96.63
diffuse bipolar 1 cell CL4033027

CSI 2.05

rCSI 15.43%

PRS 89.93
renal interstitial pericyte CL1001318

CSI 1.98

rCSI 5.45%

PRS 96.41
starburst amacrine cell CL0004232

CSI 1.96

rCSI 16.54%

PRS 88.09
glycinergic amacrine cell CL4030028

CSI 1.82

rCSI 4.73%

PRS 93.05
L6b glutamatergic cortical neuron CL4023038

CSI 1.77

rCSI 5.54%

PRS 92.04
indirect pathway medium spiny neuron CL4023029

CSI 1.76

rCSI 42.41%

PRS 89.05
direct pathway medium spiny neuron CL4023026

CSI 1.75

rCSI 41.86%

PRS 89.27
retinal ganglion cell CL0000740

CSI 1.71

rCSI 3.78%

PRS 91.81
diffuse bipolar 6 cell CL4033032

CSI 1.53

rCSI 8.04%

PRS 90.41
diffuse bipolar 3a cell CL4033029

CSI 1.21

rCSI 8.23%

PRS 91.64
flat midget bipolar cell CL4033033

CSI 0.99

rCSI 7.06%

PRS 90.85
ON parasol ganglion cell CL4033052

CSI 0.59

rCSI 8.35%

PRS 92.36
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.46

rCSI 2.7%

PRS 91.54
OFF midget ganglion cell CL4033047

CSI 0.4

rCSI 8.2%

PRS 92.15

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [HCG23](/details-gene/414764) is a non-coding RNA (ncRNA) gene located within the HLA complex on chromosome 6. Despite its location in a region heavily associated with the immune system, expression data indicates a primary role within the nervous system. **Overall**, [HCG23](/details-gene/414764) exhibits highly significant and specific expression in various neuronal subtypes, particularly in GABAergic cortical interneurons, as well as in other specialized cell types such as [interstitial cell of Cajal](/details-cell/CL0002088) and [mesothelial cell](/details-cell/CL0000077). Its notable expression in [glioblast](/details-cell/CL0000030) cells also suggests a potential involvement in neuropathology. ## Cellular Roles and Expression Landscape The expression profile of [HCG23](/details-gene/414764) strongly points to a specialized function in neural and neuro-related cell types. **Overall**, the gene is most significant as a marker for inhibitory interneurons of the cerebral cortex, with the highest Cell Significance Index (CSI) observed in [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 17.54), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 9.67), and [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: 8.02). This enrichment extends to other neuronal populations, including retinal [amacrine cell](/details-cell/CL0000561) and glutamatergic neurons, as well as progenitor cells like the [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338). Beyond the central nervous system, [HCG23](/details-gene/414764) shows high significance in [interstitial cell of Cajal](/details-cell/CL0002088) (CSI: 10.08), which are pacemaker cells that regulate gut motility, and [Schwann cell](/details-cell/CL0002573), which myelinate peripheral nerves. This pattern suggests a potential role in regulating cellular excitability or specialized signaling pathways common across these diverse cell types. The high significance in [glioblast](/details-cell/CL0000030) cells (CSI: 7.17), a type of brain tumor cell, highlights its potential relevance in oncogenic processes. ## Pathways and Molecular Function As a non-coding RNA, [HCG23](/details-gene/414764) does not encode a protein and likely functions at the RNA level, for example by regulating gene expression or participating in the formation of ribonucleoprotein complexes. Based on the available data, specific GO and Reactome pathway annotations are limited. However, its genomic location within the HLA complex at 6p21.32 is noteworthy, though its primary expression in neural tissues suggests its function may be independent of the canonical immune roles associated with this locus. ## Research Directions The highly specific expression pattern of [HCG23](/details-gene/414764) in neural cells and its presence in glioblastoma provide fertile ground for further investigation. **Proposed Testable Hypotheses:** 1. Given its high and specific expression in multiple classes of cortical interneurons, [HCG23](/details-gene/414764) may function as a key regulator in the terminal differentiation, subtype specification, or maintenance of inhibitory neuronal identity. 2. The high significance of [HCG23](/details-gene/414764) in [glioblast](/details-cell/CL0000030) cells suggests it may act as a non-coding oncogene, contributing to tumor cell survival, proliferation, or invasion by modulating key cancer-related pathways. 3. The shared expression between neurons and [interstitial cell of Cajal](/details-cell/CL0002088) may indicate that [HCG23](/details-gene/414764) regulates a common set of genes involved in establishing or maintaining electrical rhythmicity in excitable cells. **Suggested Experimental Approach:** To test the hypothesis that [HCG23](/details-gene/414764) is a functional contributor to glioblastoma pathology, a loss-of-function study is warranted. One could use CRISPR interference (CRISPRi) or antisense oligonucleotides (ASOs) to specifically knock down [HCG23](/details-gene/414764) expression in patient-derived glioblastoma stem cell lines. The functional consequences could be assessed by measuring changes in cell proliferation (e.g., Ki67 staining), invasion (e.g., Matrigel transwell assay), and the ability to form tumorspheres. Concurrently, RNA-sequencing of the knockdown cells would identify downstream transcriptional targets, revealing the molecular pathways regulated by this ncRNA. **Therapeutic Potential:** As a non-coding RNA with highly specific expression in the central nervous system and in glioblastoma, [HCG23](/details-gene/414764) presents a potential therapeutic target. If it is shown to be essential for glioblastoma cell survival, its inhibition would be the desired therapeutic strategy. Given its RNA nature, it is a suitable candidate for targeting with nucleic acid-based therapeutics, such as ASOs, which can be designed for high specificity and delivered to the brain to degrade the target transcript. The challenge would be ensuring delivery across the blood-brain barrier and minimizing potential off-target effects on the healthy neurons that also express this gene.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.