Details for: USP17L22

Gene ID: 100287513

Symbol: USP17L22

Ensembl ID: ENSG00000248933

Description: ubiquitin specific peptidase 17 like family member 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0039
    Cell Significance Index: 0.0200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0025
    Cell Significance Index: 0.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0021
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0010
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0013
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0015
    Cell Significance Index: -0.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0040
    Cell Significance Index: -0.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0043
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0046
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0065
    Cell Significance Index: -0.0800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0067
    Cell Significance Index: -0.0600
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0073
    Cell Significance Index: -0.0600
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0074
    Cell Significance Index: -0.0800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0076
    Cell Significance Index: -0.0700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0080
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -0.0085
    Cell Significance Index: -0.0600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0098
    Cell Significance Index: -0.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** USP17L22 is a cysteine-type deubiquitinase, an enzyme that removes ubiquitin molecules from target proteins, thereby regulating their activity and localization. 2. **Cellular Expression:** This gene is expressed in various cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, Cajal-Retzius cells, and cerebral cortex endothelial cells. 3. **Protein Function:** USP17L22 is involved in the regulation of protein deubiquitination, which is essential for maintaining cellular homeostasis and preventing protein degradation. 4. **Abnormal Expression:** Abnormal expression of USP17L22 has been observed in various disease states, including cancer, neurological disorders, and cardiovascular diseases. **Pathways and Functions:** 1. **Cysteine-type Deubiquitination:** USP17L22 is a cysteine-type deubiquitinase that removes ubiquitin molecules from target proteins, regulating their activity and localization. 2. **Metabolism of Proteins:** USP17L22 is involved in the regulation of protein degradation and metabolism, influencing cellular homeostasis. 3. **Regulation of Apoptotic Process:** This gene plays a crucial role in regulating the apoptotic process, a process of programmed cell death that is essential for maintaining tissue homeostasis. 4. **Proteolysis:** USP17L22 is involved in the regulation of proteolysis, a process that involves the breakdown of proteins into smaller peptides or amino acids. **Clinical Significance:** 1. **Cancer:** Abnormal expression of USP17L22 has been observed in various types of cancer, including breast, lung, and colon cancer. This gene may play a role in cancer progression and metastasis. 2. **Neurological Disorders:** USP17L22 is significantly expressed in the nervous system and has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cardiovascular Diseases:** Abnormal expression of USP17L22 has been observed in cardiovascular diseases, including atherosclerosis and heart failure. 4. **Infectious Diseases:** USP17L22 may play a role in the regulation of immune responses and has been implicated in various infectious diseases, including HIV and tuberculosis. In conclusion, the USP17L22 gene is a complex and multifunctional gene that plays a crucial role in regulating protein deubiquitination, metabolism, and apoptosis. Its abnormal expression has been implicated in various disease states, highlighting its potential as a therapeutic target for the treatment of various diseases. Further research is necessary to fully understand the mechanisms of USP17L22 and its clinical significance.

Genular Protein ID: 2091333189

Symbol: U17LM_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 22

UniProtKB Accession Codes:

D6RA61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EC 2 EMBL 1 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 530
  • Mass: 59671
  • Checksum: DE7A9593AB530FD2
  • Sequence:
    • MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR 
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH 
KGCMLCTMQA HITRALHNPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH 
KQVDHHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL 
VKPEELNGEN AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC 
LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASSIT 
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRATQGELKR DHPCLQAPEL 
DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP 
EQQSSLLKLS STTPTHQESM NTGTLASLRG RARRSKGKNK HSKRALLVCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.