Details for: DEFB128

Gene ID: 245939

Symbol: DEFB128

Ensembl ID: ENSG00000185982

Description: defensin beta 128

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.2278
    Cell Significance Index: 68.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.7834
    Cell Significance Index: 45.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.0681
    Cell Significance Index: 13.8200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.5367
    Cell Significance Index: 5.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4222
    Cell Significance Index: 7.2200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0492
    Cell Significance Index: 0.2900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0253
    Cell Significance Index: 0.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0053
    Cell Significance Index: 3.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0055
    Cell Significance Index: -1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0063
    Cell Significance Index: -1.2600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0083
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0208
    Cell Significance Index: -0.2700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0425
    Cell Significance Index: -0.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0457
    Cell Significance Index: -1.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0580
    Cell Significance Index: -0.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0610
    Cell Significance Index: -0.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0790
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0905
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0911
    Cell Significance Index: -1.2100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0931
    Cell Significance Index: -1.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0939
    Cell Significance Index: -1.2300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0961
    Cell Significance Index: -1.2600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0984
    Cell Significance Index: -1.2000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1017
    Cell Significance Index: -1.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1060
    Cell Significance Index: -1.3000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1211
    Cell Significance Index: -1.4500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1310
    Cell Significance Index: -1.2300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1449
    Cell Significance Index: -1.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1599
    Cell Significance Index: -2.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1833
    Cell Significance Index: -2.1600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2272
    Cell Significance Index: -1.9900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2625
    Cell Significance Index: -1.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3826
    Cell Significance Index: -4.1700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3909
    Cell Significance Index: -2.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5481
    Cell Significance Index: -9.2300
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.7722
    Cell Significance Index: -9.7000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.7855
    Cell Significance Index: -8.9700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -1.1660
    Cell Significance Index: -9.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -1.2741
    Cell Significance Index: -9.9100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -1.3767
    Cell Significance Index: -9.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DB128 is a small, cationic peptide consisting of 128 amino acids, with a molecular weight of approximately 4 kDa. Its sequence is highly conserved among different species, indicating a crucial role in innate immunity. DB128 is produced by various cell types, including plasmacytoid dendritic cells, megakaryocytes, and erythrocytes, suggesting a role in the activation of immune responses. The gene is also expressed in epithelial cells, including ciliated cells, which are involved in the respiratory and gastrointestinal tracts. **Pathways and Functions:** DB128 belongs to the antimicrobial peptide family, which plays a crucial role in the innate immune response against pathogens. The gene's expression is associated with several pathways, including: 1. **Defense response to Gram-negative bacterium**: DB128 has been shown to exhibit bactericidal activity against Gram-negative bacteria, such as Escherichia coli and Pseudomonas aeruginosa. 2. **Defense response to Gram-positive bacterium**: DB128 also exhibits bactericidal activity against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus pneumoniae. 3. **Killing of cells of another organism**: DB128 has been shown to induce apoptosis in cancer cells, suggesting a potential role in cancer therapy. 4. **Immune system regulation**: DB128 may play a role in regulating the immune response by modulating the activity of immune cells, such as dendritic cells and natural killer cells. **Clinical Significance:** DB128 has been implicated in various diseases, including: 1. **Infectious diseases**: DB128's antimicrobial activity makes it a potential therapeutic agent against infectious diseases, such as sepsis and pneumonia. 2. **Cancer**: DB128's ability to induce apoptosis in cancer cells suggests a potential role in cancer therapy. 3. **Autoimmune diseases**: DB128's regulatory role in the immune response may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Vaccine development**: DB128's ability to induce immune responses makes it a potential component in vaccine development. In conclusion, DB128 is a multifunctional antimicrobial peptide with a broad range of applications in immunology and medicine. Further research is needed to fully elucidate its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1806376197

Symbol: DB128_HUMAN

Name: Beta-defensin 128

UniProtKB Accession Codes:

Q7Z7B8 B2RU29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12620395

Title: Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.

PubMed ID: 12620395

DOI: 10.1016/s0888-7543(02)00034-4

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 93
  • Mass: 10650
  • Checksum: 8A0C1C72A876362D
  • Sequence:
    • MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK LCCANDEEEK 
KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.