Details for: PART1

Gene ID: 25859

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: PART1

Ensembl ID: ENSG00000152931

Description: prostate androgen-regulated transcript 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated epithelial cell CL0000067
    CSI 13.95
    rCSI 12.27%
    PRS 93.37
  • cerebral cortex endothelial cell CL1001602
    CSI 11.09
    rCSI 19.18%
    PRS 95.51
  • secretory cell CL0000151
    CSI 9.31
    rCSI 9.71%
    PRS 97
  • renal alpha-intercalated cell CL0005011
    CSI 8.17
    rCSI 10.92%
    PRS 98.19
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 8.04
    rCSI 28.92%
    PRS 91.18
  • mucus secreting cell CL0000319
    CSI 7.51
    rCSI 11.94%
    PRS 98.68
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 7.32
    rCSI 17.79%
    PRS 91.03
  • L6b glutamatergic cortical neuron CL4023038
    CSI 7.03
    rCSI 21.97%
    PRS 92.94
  • ciliated cell CL0000064
    CSI 6.82
    rCSI 11.05%
    PRS 93.89
  • lung neuroendocrine cell CL1000223
    CSI 6.7
    rCSI 9.91%
    PRS 97.31
  • duct epithelial cell CL0000068
    CSI 5.64
    rCSI 8.25%
    PRS 98.62
  • neuron CL0000540
    CSI 5.57
    rCSI 14.83%
    PRS 89.95
  • epithelial cell CL0000066
    CSI 5.56
    rCSI 8.54%
    PRS 90.4
  • cerebral cortex neuron CL0010012
    CSI 5.21
    rCSI 21.24%
    PRS 92.96
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 5.15
    rCSI 30.33%
    PRS 92.47
  • glandular epithelial cell CL0000150
    CSI 5.08
    rCSI 13.37%
    PRS 99.28
  • peripheral nervous system neuron CL2000032
    CSI 5.04
    rCSI 6.87%
    PRS 94.71
  • acinar cell CL0000622
    CSI 4.94
    rCSI 7.24%
    PRS 98.66
  • club cell CL0000158
    CSI 4.6
    rCSI 6.74%
    PRS 96.14
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 4.41
    rCSI 16.68%
    PRS 92.2
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.35
    rCSI 4.18%
    PRS 96.75
  • myoepithelial cell CL0000185
    CSI 3.89
    rCSI 9.83%
    PRS 98.32
  • mucous neck cell CL0000651
    CSI 3.72
    rCSI 5.36%
    PRS 97.76
  • lung ciliated cell CL1000271
    CSI 3.58
    rCSI 4.13%
    PRS 94.93
  • multi-ciliated epithelial cell CL0005012
    CSI 3.2
    rCSI 3.19%
    PRS 94.77
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 3.16
    rCSI 6.85%
    PRS 90.7
  • nasal mucosa goblet cell CL0002480
    CSI 3.04
    rCSI 3.52%
    PRS 96.75
  • serous secreting cell CL0000313
    CSI 2.94
    rCSI 14.85%
    PRS 98.01
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.77
    rCSI 6.32%
    PRS 93.34
  • enteroendocrine cell CL0000164
    CSI 2.68
    rCSI 3.66%
    PRS 96.04
  • tuft cell of colon CL0009041
    CSI 2.45
    rCSI 5.7%
    PRS 97.17
  • intestinal tuft cell CL0019032
    CSI 1.96
    rCSI 3%
    PRS 97.24
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 1.92
    rCSI 10.91%
    PRS 96.66
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.91
    rCSI 6.28%
    PRS 91.08
  • tracheobronchial serous cell CL0019001
    CSI 1.9
    rCSI 8.2%
    PRS 97.94
  • luminal cell of prostate epithelium CL0002340
    CSI 1.88
    rCSI 10.11%
    PRS 98.16
  • tracheal goblet cell CL1000329
    CSI 1.75
    rCSI 3.82%
    PRS 97.76
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.55
    rCSI 3.72%
    PRS 91.96
  • endothelial cell of uterus CL0009095
    CSI 1.22
    rCSI 8.95%
    PRS 99.15
  • acinar cell of salivary gland CL0002623
    CSI 0.56
    rCSI 12.98%
    PRS 98.68

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PART1](/details-gene/25859) (prostate androgen-regulated transcript 1) is a non-coding RNA gene located on chromosome 5q12.1. Expression data suggests it plays a significant role in a diverse array of specialized cell types. **Overall**, it demonstrates high significance in epithelial cells with secretory and motile functions, such as [ciliated epithelial cell](/details-cell/CL0000067) and [secretory cell](/details-cell/CL0000151), as well as in specific neuronal populations, particularly glutamatergic cortical neurons. This expression profile points towards a potential regulatory function in processes related to cellular transport, secretion, and the maintenance of specific neuronal identities. ## Cellular Roles and Expression Landscape The expression pattern of [PART1](/details-gene/25859) indicates a role in multiple, functionally distinct cell lineages. Its highest significance is observed in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 13.95), suggesting a potential function in regulating cilia formation or motility. This is further supported by its high significance in related cell types like [secretory cell](/details-cell/CL0000151) (CSI: 9.31), [mucus secreting cell](/details-cell/CL0000319) (CSI: 7.51), and [duct epithelial cell](/details-cell/CL0000068) (CSI: 5.64), pointing to a broader involvement in epithelial barrier and transport functions. A second major functional context for [PART1](/details-gene/25859) is the central nervous system. It is a significant marker for [cerebral cortex endothelial cell](/details-cell/CL1001602) (CSI: 11.09), which form the blood-brain barrier. Furthermore, it shows highly specific expression in several subtypes of glutamatergic cortical neurons, including [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) (CSI: 8.04), [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 7.32), and [L6b glutamatergic cortical neuron](/details-cell/CL4023038) (CSI: 7.03). This restricted neuronal expression pattern suggests that [PART1](/details-gene/25859) may be involved in establishing or maintaining the specialized functions of these specific neuronal circuits. ## Pathways and Molecular Function While detailed functional annotations are not provided, the identity of [PART1](/details-gene/25859) as a non-coding RNA suggests it functions through gene regulation, potentially acting as a scaffold for protein complexes or by modulating transcription of target genes. Its co-expression within ciliated and secretory epithelial cells implies a role in pathways governing ciliogenesis, mucus production, or ion transport. Similarly, its specific expression in cortical neurons points towards involvement in processes such as synaptic transmission, axon guidance, or the maintenance of neuronal identity. ## Research Directions The specific expression patterns of the non-coding RNA [PART1](/details-gene/25859) in distinct cellular contexts suggest several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in [ciliated epithelial cell](/details-cell/CL0000067) and [secretory cell](/details-cell/CL0000151), [PART1](/details-gene/25859) may function as a lncRNA that regulates a transcriptional program essential for cellular differentiation and function in mucociliary tissues, such as the respiratory tract or fallopian tubes. 2. The highly specific expression of [PART1](/details-gene/25859) across discrete glutamatergic neuron subtypes in the cerebral cortex suggests it acts as a key regulator in defining the molecular identity, synaptic connectivity, or functional properties unique to these neuronal populations. **Experimental Approach:** To test the hypothesis regarding its role in epithelial function (Hypothesis 1), an effective approach would be to use an *in vitro* air-liquid interface (ALI) culture system with primary human bronchial epithelial cells, which recapitulates the differentiation of ciliated and secretory cells. One could perform a loss-of-function study by transfecting these cultures with antisense oligonucleotides (ASOs) targeting [PART1](/details-gene/25859). The effects could be assessed by measuring changes in cilia beat frequency via high-speed microscopy, quantifying mucus production using assays for MUC5AC/MUC5B, and analyzing the global transcriptomic changes via RNA-sequencing to identify downstream regulatory targets. **Therapeutic Potential:** As a non-coding RNA, [PART1](/details-gene/25859) presents a tractable target for RNA-based therapeutics like ASOs. Given its high expression in secretory and ciliated cells, it could be a potential therapeutic target in diseases characterized by mucociliary dysfunction, such as chronic obstructive pulmonary disease (COPD) or cystic fibrosis. If its overexpression contributes to mucus hypersecretion, therapeutic inhibition could be beneficial. Conversely, if it is essential for ciliary function, strategies to enhance its expression could be explored for certain ciliopathies. Its specificity to these cell types may allow for targeted intervention with a reduced risk of off-target effects in other tissues.