Details for: IGHVII 44 2

Gene ID: 28366

Symbol: IGHVII 44 2

Ensembl ID: ENSG00000253895

Description: immunoglobulin heavy variable (II)-44-2 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0
    Marker Score: 7

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 44 2 is a pseudogene, meaning that it lacks the typical coding potential of a functional gene. However, its expression is not limited to non-functional genes, as it is significantly expressed in precursor B cells, immature B cells, double-negative thymocytes, pro-B cells, fraction A pre-pro B cells, thymocytes, small pre-B-II cells, germ cells, double-positive alpha-beta thymocytes, and large pre-B-II cells. This widespread expression suggests that IGHVII 44 2 may play a role in the development and maturation of immune cells, possibly through mechanisms that are not yet fully understood. **Pathways and Functions:** The mechanisms underlying the expression and function of IGHVII 44 2 are not well characterized. However, several theories have been proposed: 1. **Regulation of B cell development:** IGHVII 44 2 may play a role in regulating B cell development, particularly during the transition from pro-B cells to large pre-B-II cells. Its expression may be influenced by B cell-specific transcription factors, such as Pax5 and Oct-2. 2. **Thymocyte development:** IGHVII 44 2 is also expressed in thymocytes, suggesting a role in thymocyte development and selection. Its expression may be influenced by thymocyte-specific transcription factors, such as T-box 21 (Tbx21) and Runx1. 3. **Immune tolerance:** IGHVII 44 2 may contribute to immune tolerance by regulating the expression of immune suppressive genes in regulatory T cells and other immune cells. **Clinical Significance:** The clinical significance of IGHVII 44 2 is still unclear, but its expression in various immune cells suggests that it may play a role in the development of autoimmune diseases, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia. Additionally, IGHVII 44 2 may be involved in the pathogenesis of certain cancers, such as B cell lymphomas and leukemias. In conclusion, the immunoglobulin heavy variable region II-44-2 (IGHVII 44 2) gene is a pseudogene with widespread expression in immune cells. Its mechanisms of action and clinical significance are not yet fully understood, but its role in regulating B cell development, thymocyte development, and immune tolerance make it an important area of research in immunology. Further studies are needed to elucidate the functions of IGHVII 44 2 and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.