Details for: IGHVII 44 2

Gene ID: 28366

Symbol: IGHVII 44 2

Ensembl ID: ENSG00000253895

Description: immunoglobulin heavy variable (II)-44-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2452
    Cell Significance Index: 3.1100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.0712
    Cell Significance Index: 0.6700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0655
    Cell Significance Index: 0.7400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0607
    Cell Significance Index: 0.7200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0246
    Cell Significance Index: 0.3200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0110
    Cell Significance Index: 0.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0075
    Cell Significance Index: 0.0900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0059
    Cell Significance Index: -0.1600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0072
    Cell Significance Index: -0.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0080
    Cell Significance Index: -0.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0111
    Cell Significance Index: -0.0700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0137
    Cell Significance Index: -0.1400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0146
    Cell Significance Index: -0.1600
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0186
    Cell Significance Index: -0.1600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0190
    Cell Significance Index: -0.1900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0193
    Cell Significance Index: -0.1800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0195
    Cell Significance Index: -0.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0196
    Cell Significance Index: -0.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0221
    Cell Significance Index: -0.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0221
    Cell Significance Index: -0.2400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.0271
    Cell Significance Index: -0.1400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0278
    Cell Significance Index: -0.1300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0369
    Cell Significance Index: -0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0377
    Cell Significance Index: -0.4200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0429
    Cell Significance Index: -0.4300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0487
    Cell Significance Index: -0.4300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0490
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 44 2 is a pseudogene, meaning that it lacks the typical coding potential of a functional gene. However, its expression is not limited to non-functional genes, as it is significantly expressed in precursor B cells, immature B cells, double-negative thymocytes, pro-B cells, fraction A pre-pro B cells, thymocytes, small pre-B-II cells, germ cells, double-positive alpha-beta thymocytes, and large pre-B-II cells. This widespread expression suggests that IGHVII 44 2 may play a role in the development and maturation of immune cells, possibly through mechanisms that are not yet fully understood. **Pathways and Functions:** The mechanisms underlying the expression and function of IGHVII 44 2 are not well characterized. However, several theories have been proposed: 1. **Regulation of B cell development:** IGHVII 44 2 may play a role in regulating B cell development, particularly during the transition from pro-B cells to large pre-B-II cells. Its expression may be influenced by B cell-specific transcription factors, such as Pax5 and Oct-2. 2. **Thymocyte development:** IGHVII 44 2 is also expressed in thymocytes, suggesting a role in thymocyte development and selection. Its expression may be influenced by thymocyte-specific transcription factors, such as T-box 21 (Tbx21) and Runx1. 3. **Immune tolerance:** IGHVII 44 2 may contribute to immune tolerance by regulating the expression of immune suppressive genes in regulatory T cells and other immune cells. **Clinical Significance:** The clinical significance of IGHVII 44 2 is still unclear, but its expression in various immune cells suggests that it may play a role in the development of autoimmune diseases, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia. Additionally, IGHVII 44 2 may be involved in the pathogenesis of certain cancers, such as B cell lymphomas and leukemias. In conclusion, the immunoglobulin heavy variable region II-44-2 (IGHVII 44 2) gene is a pseudogene with widespread expression in immune cells. Its mechanisms of action and clinical significance are not yet fully understood, but its role in regulating B cell development, thymocyte development, and immune tolerance make it an important area of research in immunology. Further studies are needed to elucidate the functions of IGHVII 44 2 and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.