Details for: IGHV7 34 1

Gene ID: 28382

Symbol: IGHV7 34 1

Ensembl ID: ENSG00000253325

Description: immunoglobulin heavy variable 7-34-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.0560
    Cell Significance Index: 0.5900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0060
    Cell Significance Index: 0.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0069
    Cell Significance Index: -0.0700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0131
    Cell Significance Index: -0.1300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0188
    Cell Significance Index: -0.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0196
    Cell Significance Index: -0.2500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0198
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0202
    Cell Significance Index: -0.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0204
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0208
    Cell Significance Index: -0.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0216
    Cell Significance Index: -0.2300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0216
    Cell Significance Index: -0.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0227
    Cell Significance Index: -0.2300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0232
    Cell Significance Index: -0.2000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0247
    Cell Significance Index: -0.1700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0247
    Cell Significance Index: -0.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0256
    Cell Significance Index: -0.3200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0258
    Cell Significance Index: -0.2200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0258
    Cell Significance Index: -0.2300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0270
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0270
    Cell Significance Index: -0.2600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0280
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0287
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0314
    Cell Significance Index: -0.2600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0327
    Cell Significance Index: -0.2900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0361
    Cell Significance Index: -0.2900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0418
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0446
    Cell Significance Index: -0.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0450
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0505
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0542
    Cell Significance Index: -0.5700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0645
    Cell Significance Index: -0.5900
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: -0.0707
    Cell Significance Index: -0.2300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1024
    Cell Significance Index: -0.5500
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1182
    Cell Significance Index: -0.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1300
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHV7 34 1 is a pseudogene, meaning it has undergone mutations and deletions that render it non-functional in producing a mature antibody. Despite this, it retains some regulatory functions. 2. **Widespread expression:** IGHV7 34 1 is expressed in various immune cells, including IgA plasma cells, stromal cells, B cells, and T cells, highlighting its potential role in immune regulation. 3. **Cell-type specificity:** The expression of IGHV7 34 1 varies across different cell types, suggesting a cell-type-specific function or regulatory mechanism. **Pathways and Functions:** 1. **Immunoglobulin class-switching:** Research suggests that IGHV7 34 1 may play a role in regulating immunoglobulin class-switching, a process by which B cells switch from producing one type of antibody to another. 2. **T cell regulation:** IGHV7 34 1 has been found to be expressed in T cells, including T follicular helper cells, suggesting a potential role in regulating T cell function and interaction with B cells. 3. **Stromal cell regulation:** The expression of IGHV7 34 1 in stromal cells may contribute to the regulation of immune cell development and function within the immune microenvironment. **Clinical Significance:** 1. **Immunological disorders:** The dysregulation of IGHV7 34 1 expression has been implicated in various immunological disorders, including autoimmune diseases and immune deficiencies. 2. **Cancer:** The expression of IGHV7 34 1 has been found in certain types of cancer, suggesting a potential role in tumorigenesis or immune evasion. 3. **Immunotherapy:** The understanding of IGHV7 34 1's regulatory functions may provide insights into the development of novel immunotherapeutic strategies, targeting the gene or its downstream pathways to modulate immune responses. In conclusion, IGHV7 34 1 is a complex pseudogene with far-reaching implications in immune regulation. Further research is necessary to elucidate the mechanisms by which this gene influences immune cell development, function, and interaction, ultimately shedding light on its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.